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Children with attention deficit hyperactivity disorder (ADHD) do not have a behavioral disorder, nor are they lazy, or lacking in manners and boundaries. Their brains mature in a different way, with different patterns of neurological activity and a number of neurochemical differences. For this reason, ADHD is considered to be a neurodevelopmental disorder.

These neurological imbalances manifest as attention difficulties, disorganization, or hyperactivity and impulsivity. While these are most noticeable in childhood, where prevalence is estimated at 5%, ADHD can persist into adulthood, where prevalence is 2.5% of the population. ADHD can therefore have social, academic and occupational impacts throughout a person’s life.

Although there are risk factors (such as mothers smoking during pregnancy or ), these have not been shown to directly cause ADHD. Genetic factors play a more significant role, as 74% of cases are hereditary.

The development of biomaterials for artificial organs and tissues is an active area of research due to increases in accidental injuries and chronic diseases, along with the entry into a super-aged society. 3D bioprinting technology, which uses cells and biomaterials to create three-dimensional artificial tissue structures, has recently gained popularity. However, commonly used hydrogel-based bioinks can cause cytotoxicity due to the chemical crosslinking agent and ultraviolet light that connect the molecular structure of photocuring 3D-printed bioink.

Dr. Song Soo-chang’s research team at the Center for Biomaterials, Korea Institute of Science and Technology (KIST), revealed the first development of poly(organophosphazene) hydrogel-based temperature-sensitive that stably maintained its physical structure by temperature control only without photocuring, induced tissue regeneration, and then biodegraded in the body after a certain period of time.

Current hydrogel-based bioinks must go through a photocuring process to enhance the mechanical properties of the 3D scaffold after printing, with a high risk of adverse effects in the human body. In addition, there has been a possibility of side effects when transplanting externally cultured cells within bioink to increase the tissue regeneration effect.

RUDN chemists have synthesized metal complexes on the basis of the organoelemental substance silsesquioxane that consists of an organic and an inorganic part. Such hybrid systems may be used as efficient catalysts, for example, to obtain alcohols from alkanes. The work was published in the Inorganic Chemistry journal.

Physical and chemical parameters of any material or substance are limited and cannot be infinitely improved. So scientists work on hybrid materials that combine different components and therefore demonstrate new properties. In modern chemistry, special attention is paid to compounds that consist of metal centers and organic “bridges” that keep them together. Such objects have a number of valuable properties and may be used for industrial purposes: catalysis, storage of gases, accurate separation of mixed . They can also be used to create chemical sensors and agents to deliver drugs to their targets in the body.

Hybrid organoelemental substances such as silsesquioxanes consist of an inorganic main chain Si-O-Si and an organic framework of Si atoms. Compounds like this can be formed when metal atoms are added to carcass structures with promising catalytic and magnetic properties. RUDN chemists suggested a new approach to such compounds based on the use of additional complex-forming substances (ligands).

Electrochemical stimuli-responsive materials are gaining more attention in the world of display technology. Based on external stimuli, such as low voltage, these materials can instantaneously undergo electrochemical reactions.

These electrochemical reactions can result in the production of different colors, enhancing options. An electrochemical system consists of electrodes and electrolytes. Combining the luminescent and coloration molecules on the electrodes instead of the electrolyte can offer higher efficiencies and stability for display devices.

To this end, a research team from Japan employed clay membranes to effectively integrate the coloration and luminescence molecules. Their innovative dual-mode electrochemical device merges the ability to emit light and change color, offering a highly adaptable and energy-efficient solution for modern displays.

Summry: New research reveals that dopamine plays a crucial role in teaching young male mice to fight, with the chemical’s influence diminishing as they gain experience. In novice fighters, boosting dopamine increased aggression, while blocking it stopped them from fighting.

However, experienced fighters showed no changes in behavior regardless of dopamine manipulation, highlighting the role of experience in shaping aggression. The study identifies the lateral septum as a key brain region for “aggression learning” in males, but no similar effect was observed in females.

‘Earth factory’ method cooks up clean fertilizer underground.

In the 1980s, well diggers in Mali, West Africa uncovered an unusual geological phenomenon: a well streaming with hydrogen gas, which scientists traced back to chemical reactions between water and rock occurring deep within the Earth. Now, researchers are harnessing our planet’s natural heat and pressure to cook up ammonia for fertilizer—potentially reducing the need for chemical plants powered by fossil fuels.

Ammonia, which is primarily used as a source for nitrogen fertilizer and also being considered for use as a green fuel, is the most widely produced chemical in the world today. Unfortunately, the standard method for making ammonia, known as the Haber-Bosch process, consumes enormous amounts of energy—making it a major source of greenhouse gas emissions. In fact, ammonia production is the chemical industry’s biggest greenhouse gas emitter.

Chromatin, the mix of DNA and protein that houses each cell’s genome, is more resilient to aging than previously thought, suggests a study published in the Journal of the American Chemical Society by researchers at King’s College London.

Scientists believe this may reveal how the body can cope with the inevitable “wear-and-tear” of aging and where it may be more vulnerable to its effects, laying the groundwork for future anti-aging treatments throughout the body.

Proteins, much like the rest of the body, change when aging. This is especially the case for the that make up , which may “live” for ~100 days before being replenished and replaced. During their lifetime, proteins are stretched and distorted, or experience processes that are similar to rusting. This damage results in naturally occurring to the protein called post-translational modifications, or PTMs.

Everyone has their favourite example of a trick that reliably gets a certain job done, even if they don’t really understand why. Back in the day, it might have been slapping the top of your television set when the picture went fuzzy. Today, it might be turning your computer off and on again.

Quantum mechanics — the most successful and important theory in modern physics — is like that. It works wonderfully, explaining things from lasers and chemistry to the Higgs boson and the stability of matter. But physicists don’t know why. Or at least, if some of us think we know why, most others don’t agree.

He has written five well received books on consciousness and developed the Global Neural Workspace model of Consciousness What follows bellow are some of Professor Baars’ observations, Questions (often rhetorical), Quotations, comments, reflections on career and his own theories and my comments (RS) to them as posted to LinkedIn platform. Bernard’s text is in italics. Comments to comments are indicated with ‘BB]’ and responses to those with ‘RS]’. ======== ======== ======== t aware of. ‘ +In the case of non-human animals, we have to get a little bit more creative. We have to decide what behaviors can be used similar sorts of markers as their own form of report.” — David Edelman RS] Or we could ask ~ “is the form of communication between animals sufficient for their needs?” and follow up with “is there Evolutionary Pressure for forms of communication beyond utility?” Those who follow discussion forums may appreciate that what takes an excited discussant 10 paragraphs and 1,000 flaming words can be achieved by a dog with a couple barks and the bearing of teeth ~ which is the more efficient communicative format? BB] Humans seem to have a larger repertoire of uses for consciousness — including language and longer-term planning, self-monitoring and self-reflection, inner speech, metaphor, symbolic representation of experience and deliberate use of imagery. When it comes to sensory consciousness, however, the brain shows little difference between humans and many other mammals. RS] Utility is the key ~ what are those faculties good for? Take them away, individually, and see what we end up with. As such surgical or other intervention is not a practical option we might turn to clinical conditions where patients have such deficits. We may look to Autism, where self reflection, especially in the social context, is lacking. Psychopathy, where there is no inner voice reflecting on social morals. Various other deficits leave individuals with greatly reduced capacity to strive in a community and so we may reflect on the many cognitive faculties we have that appear to have little if any use for the isolated individual. To test this we may examine those who were completely isolated for a significant period of their maturation. There have been cases of children lost in the forest (or dumped there) who survived. Without social stimulation some of heir faculties never matured ~ are these the same faculties that Bernard mentions above? BB] Perhaps half a second after you glance at a word on a page it is converted into a semantic code, to interpret its meaning, guided by the rules of grammar. Going from words to meaning requires a large, unconscious mental lexicon. The lexicon of educated speakers of English contains about 100,000 words. We can understand each one instantly, as soon as it is shown in a sentence that makes sense. Words are complicated things! The OxfordEnglish Dictionary, for example, devotes 75,000 words to clarifying the many different meanings of the word set. RS] The way words are interpreted gives us insight into the how the brain works. If approached in the follow manner we can see what is happening: For each noun there is a denotation and a connotation (the cold dictionary definition and the feeling the word evokes eg ‘Home’). There is a stand alone and contextual meaning of a word that may differ significantly eg “child” and “What are parent-child tree structures in SQL?” The ‘connotation’ is used by the brain to link words into sentences more so than the denotation. If there is a universal background language in the brain, then, it would be based on connotation, not denotation. Why? Because the connotation is innate already and words are appended to pre-existing ‘connotation’ made up of emotion, drives, feelings of all kinds. Watch a child as they acquire their first words ~ they at first use all kinds of signals to convey their intent, their intent is made up of drives, cravings, feelings etc and these become the connotations behind the words they eventually use. s BB] How does the metaphor of a theater help us think about consciousness? RS] The key to many of these approaches, and possible the downfall of at least some of them, is ‘evolvability’. We assume, from our own intuitive experience and logical deduction, that there must be a primary central control. This is a ‘top-down’ approach. But evolution must, by necessity, be ‘bottom-up’. Thus we would expect even the simplest ganglion to have at least some of the properties of consciousness in its own right. Snakes that must rely on different ‘consciousnesses’ for various functions, for instance the pursuing of prey, the killing of prey and the eating of the prey all come from processes so separate that if a mouse after a poisonous bite staggers around and ends up under the snake’s nose the snake will follow the scent trail until it ends up at the mouse, the visual and feeding systems not being able to share information. That system is evolvable, the top-down, apart from religious models, is not evolvable. Thus instead of a separate central process looking down at the senses we consider how the senses and other contributors to cognition swirl together like the funnel of a tornado to form a central consciousness that, in reality, has no independent neural underpinnings of its own due to its emergent nature. Note that ‘life’ also has this nature in that life exists when a collection of chemical reactions ‘swirl’ together, principally in a negative feedback driven homeostatic process, which is most probably also what consciousness actually is… And so we observe how the tornado’s funnel moves around the possible contributors, the audience in the analogy given, rather than a separate process that looks at individual members of the audience. Note that the separate process must consume the information on offer and process it, a ‘infinite regress’ with no end. But the swirling tornado, so to speak, is its own end and does not require any subsequent processes or processing… Note also that any collection of neurons, brain modules or even collections or communities of people can initiate this process.


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