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Category: chemistry – Page 12

Tracing brain chemistry across humanity’s family tree

The evolutionary success of our species may have hinged on minute changes to our brain biochemistry after we diverged from the lineage leading to Neanderthals and Denisovans about half a million years ago.

Two of these tiny changes that set modern humans apart from Neanderthals and Denisovans affect the stability and genetic expression of the adenylosuccinate lyase, or ADSL. This enzyme is involved in the biosynthesis of purine, one of the fundamental building blocks of DNA, RNA, and other important biomolecules.

In a study published in PNAS, researchers from the Okinawa Institute of Science and Technology (OIST), Japan and the Max Planck Institute for Evolutionary Anthropology, Germany have discovered that these changes may play an important role in our behavior, contributing new pieces to the great puzzle of who we humans are and where we come from.

Altered protein translation elongation contributes to brain aging

The GFP gene, which has its origins in jellyfish, expresses proteins that fluoresce when illuminated with certain frequencies of light. Poeschla, of the Mayo Clinic in Rochester, Minnesota, reported his results in the journal Nature Methods.

This function is regularly used by scientists to monitor the activity of individual genes or cells in a wide variety of animals. The development and refinement of the GFP technique earned its scientific pioneers the Nobel prize for chemistry in 2008.

In the case of the glowing cats, the scientists hope to use the GM animals in the study of HIV/AIDS.

In vitro anti-cancer efficacy and phyto-chemical screening of solvent extracts of Kigelia africana (Lam.) Benth

Kigelia africana is a medicinal plant growing naturally in many parts of Africa. In Kenya, a water concoction of the plant is used to treat breast and prostate cancers. Laboratory data on its anti-cancer activity and active principles is limited, hence no scientific rationale for its medicinal use. This study reports on in-vitro toxic activities of dichloromethane and methanol extracts of the plant against human breast cancer cells and phytochemical screening of the two extracts.

Scientists just recreated the Universe’s first molecule and solved a 13-billion-year-old puzzle

Long before stars lit up the sky, the universe was a hot, dense place where simple chemistry quietly set the stage for everything to come. Scientists have now recreated the first molecule ever to form, helium hydride, and discovered it played a much bigger role in the birth of stars than we thought. Using a special ultra-cold lab setup, they mimicked conditions from over 13 billion years ago and found that this ancient molecule helped cool the universe just enough for stars to ignite. Their findings could rewrite part of the story about how the cosmos evolved from darkness to light.

Researchers identify protein patterns linked to chemotherapy resistance in bladder cancer

About one quarter of patients with muscle-invasive bladder cancer (MIBC) may be treated and derive a benefit with the current standard chemotherapy. To better understand why some tumors resist chemotherapy and identify better ways to treat those cancers, researchers at Baylor College of Medicine have conducted a detailed molecular analysis of MIBC tumors. The results, published in Cell Reports Medicine, offer potential new ways to identify which patients will benefit from chemotherapy and reveal possible new treatment strategies.

“One of our goals was to identify molecular markers in patient tumors that would help us predict which patients were most likely to benefit from chemotherapy and which ones might not,” said first co-author, Dr. Matthew V. Holt, director of the Lester and Sue Smith Breast Center Proteomics Laboratory at Baylor.

The researchers studied 60 MIBC tumor samples using a comprehensive multi-omics approach which included genomics (sequencing the genes of the tumor), transcriptomics (analyzing which genes are turned on or off), proteomics (the proteins produced by the tumor) and phosphoproteins (proteins with chemical tags that control their activity).

A Quantum Interface Revolution: Discovering a New State of Matter at the Edge of the Unknown

Please find under this blog the latest updates on exciting news happening every day in the world of Materials Science and Materials Chemistry research and development (with a special emphasis on the Computational aspects of these research fields), via our diverse selection of news articles! Many thanks for your interest and support, Dr. Gabriele Mogni Email contact: [email protected] Website: www.qscomputing.com

Protein condensate sequesters synaptic vesicles at the release site

Message transfer from brain cell to brain cell is key to information processing, learning and forming memories. The bubbles, synaptic vesicles, are housed within the synapse — the connection point where brain cells communicate. In typical synapses within the brains of mammals, 300 synaptic vesicles are clustered together in the intersection between any two brain cells, but only a few of these vesicles are used for such message transfer, researchers say. Pinpointing how a synapse knows which vesicles to use has long been a target of research by those who study the biology and chemistry of thought.

In an effort to better understand the operation of these synaptic vesicles, the team designed a study that first focused on endocytosis, a process in which brain cells recycle synaptic vesicles after they are used for neuronal communication.

Already aware of intersectin’s general role in endocytosis and neuronal communication, the scientists genetically engineered mice to lack the gene that codes for intersectin. However, and somewhat to their surprise, the lead says removing the protein did not appear to halt endocytosis in brain cells.

The research team refocused their experiments, taking a closer look at the synaptic vesicles themselves.

Using a high-resolution fluorescence microscope to observe where intersectin is in a synapse, the researchers found it in between vesicles that are used for neuronal communication and those that are not, as if they are physically separating the two.

To further understand the role of intersectin at this location, they used an electron microscope to visualize synaptic vesicles in action across one billionth of a meter. In all the nerve cells from mice lacking this protein, the scientists say synaptic vesicles close to the membrane were absent from the release zone of the synapse, the place where the bubbles would discharge to nearby neurons.

“This suggested that intersectin regulates release, rather than recycling, of these vesicles at this location of the synapse,” says the author.

Continue reading “Protein condensate sequesters synaptic vesicles at the release site” | >

U of I lab to receive $15M for AI tool development, molecular innovation

CHAMPAIGN-URBANA, Ill. (WCIA) — The U.S. National Science Foundation has awarded a University of Illinois lab $15 million. The money will support the development of AI tools, to help scientists quickly and efficiently synthesize molecules for medicine, energy, industry and more.

The money will be going to the Molecule Maker Lab Institute (MMLI) — which is based on the U of I’s campus, in partnership between Pennsylvania State University and the Georgia Institute of Technology. U of I chemical and biomolecular engineering professor Huimin Zhao directs the lab.

Zhao said functional molecules like drugs chemicals are important in today’s society, but the process of discovering new molecules is slow and expensive. He believes AI can change that.

High-quality crystals enable new insights into structure–property relationships and multifunctionality

Researchers at Kumamoto University and Nagoya University have developed a new class of two-dimensional (2D) metal-organic frameworks (MOFs) using triptycene-based molecules, marking a breakthrough in the quest to understand and enhance the physical properties of these promising materials. The work is published in the Journal of the American Chemical Society.

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