Lifeboat Foundation

Research from the University of California, Irvine has revealed how disruption of the circadian clock, the body’s internal, 24-hour biological pacemaker, may accelerate the progression of colorectal cancer by affecting the gut microbiome and intestinal barrier function. This discovery offers new avenues for prevention and treatment strategies.

The study, published online today in the journal Science Advances, offers a more comprehensive understanding of how important changes occur in the function and composition of the gut microbiome when the circadian clock is disturbed in the presence of colorectal cancer.

“There is an alarming rise in early-onset colorectal cancer in adults under the age of 50,” said corresponding author Selma Masri, associate professor of biological chemistry. “Circadian misalignment through extended light exposure, late-night meals and other environmental factors could [be] driving these cases. Our study suggests that clock disruption, particularly through lifestyle choices, may play a significant role in gut health and, subsequently, cancer risk.”

Imagine tires that charge a vehicle as it drives, streetlights powered by the rumble of traffic, or skyscrapers that generate electricity as the buildings naturally sway and shudder.

These energy innovations could be possible thanks to researchers at Rensselaer Polytechnic Institute developing environmentally friendly materials that produce electricity when compressed or exposed to vibrations.

In a recent study published in the journal Nature Communications, the team developed a polymer film infused with a special chalcogenide perovskite compound that produces electricity when squeezed or stressed, a phenomenon known as the piezoelectric effect. While other piezoelectric materials currently exist, this is one of the few high-performing ones that does not contain lead, making it an excellent candidate for use in machines, infrastructure as well as bio-medical applications.

In 2005, the futurist Ray Kurzweil predicted that by 2045, machines would become smarter than humans. He called this inflection point the “singularity,” and it struck a chord. Kurzweil, who’s been tracking artificial intelligence since 1963, gained a fanatical following, especially in Silicon Valley.

Now comes The Singularity is Nearer: When We Merge with A.I. where Kurzweil steps up the Singularity’s arrival timeline to 2029. “Algorithmic innovations and the emergence of big data have allowed AI to achieve startling breakthroughs sooner than expected,” reports Kurzweil. From winning at games like Jeopardy! and Go to driving automobiles, writing essays, passing bar exams, and diagnosing cancer, chunks of the Singularity are arriving daily, and there’s more good news just ahead.

Very soon, predicts Kurzweil, artificial general intelligence will be able to do anything a human can do, only better. Expect 3D printed clothing and houses by the end of this decade. Look for medical cures that will “add decades to human life spans” just ahead. “These are the most exciting and momentous years in all of history,” Kurzweil noted in an interview with Boston Globe science writer Brian Bergstein.

An international team of neuroscientists, led by Duke-NUS Medical School, have uncovered a mechanism that controls the reactivation of neural stem cells, which are crucial for repairing and regenerating brain cells.

The research, published in Nature Communications, offers exciting potential for advancing our understanding and treatment of common neurodegenerative diseases like Alzheimer’s and Parkinson’s disease.

Neural stem cells are the source of the brain’s primary functional cells. After the initial development of the brain, neural stem cells typically enter a dormant state, conserving energy and resources. They re-awaken only when the brain needs them, such as after an injury or with physical exercise.

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Although UBTech is leaving 10% of work for humans in management, other AI tech is being specifically developed for that niche: OpenAI’s new framework, Swarm, allows AI agents to collaborate and independently execute complex tasks, potentially boosting business efficiency.

Artificial intelligence agents are everywhere, quietly reshaping industries and automating tasks we didn’t think possible a few years ago. Unlike basic automation, these AI agents can handle complex jobs, think independently and learn from their environment. The result? Healthcare, finance and logistics businesses are seeing rapid gains in efficiency — and, in some cases, doing away with manual work altogether.

What are AI agents exactly? They’re software programs that carry out specific tasks without constant supervision. Whether handling customer requests, diagnosing medical conditions or predicting market trends, AI agents are versatile workhorses. Instead of waiting for humans to input every command, these agents operate autonomously, reacting to real-time data and adjusting their actions accordingly.

Continue reading “AI Explained: AI Agents Are Quietly Taking Over Everyday Tasks” »

This study presents the development and characterization of a novel nanocomposite wound dressing material based on polylactic acid (PLA) nanofibers incorporating chitosan nanocapsules loaded with chamomile extract and cellulose nanoparticles.

Asadzadeh, F., Ghorbanzadeh, S., Poursattar Marjani, A. et al. Sci Rep 14, 22,336 (2024). https://doi.org/10.1038/s41598-024-72398-9

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Continue reading “Assessing polylactic acid nanofibers with cellulose and chitosan nanocapsules loaded with chamomile extract for treating gram-negative infections” »

The research focuses on “cellular senescence,” a process where cells stop dividing and enter a state associated with chronic inflammation and aging.

This cellular state, known as the senescence-associated secretory phenotype (SASP), involves the secretion of inflammatory proteins that accelerate aging and disease, such as dementia, diabetes, and atherosclerosis.

How do plants and fungi communicate with each other? This is what a recent study published in Molecular Cell hopes to address as an international team of researchers investigated the “language” conducted between plants and fungi that enables fungi growth. This study holds the potential to help scientists and farmers better understand how to fight disease-causing fungi by growing crops with greater resilience and adversity.

“As we begin to understand how plants and fungi communicate, we will better understand the complexities of the soil ecosystem, leading to healthier crops and improving our approach to biodiversity,” said Dr. Shelley Lumba, who is an assistant professor in the Department of Cell and Systems Biology at the University of Toronto and a co-author on the study.

For the study, the researchers examined strigolactone (SL), which is a class of plant hormones and signaling molecules responsible for plant development, with the team focusing on how SL influences fungi growth and development by testing SL with yeast. In the end, the researchers found that SL triggered certain genes called “PHO” that are responsible for phosphate metabolism, along with finding that plants release SL when they are low on phosphate, forcing the yeast to alter the amount of phosphate consumes by triggering the protein, Pho84.