Lifeboat Foundation

Editor’s note: This story is being highlighted in ASU Now’s year in review. Read more top stories from 2018 here.

In a major advancement in nanomedicine, Arizona State University scientists, in collaboration with researchers from the National Center for Nanoscience and Technology (NCNST) of the Chinese Academy of Sciences, have successfully programmed nanorobots to shrink tumors by cutting off their blood supply.

“We have developed the first fully autonomous, DNA robotic system for a very precise drug design and targeted cancer therapy,” said Hao Yan, director of the ASU Biodesign Institute’s Center for Molecular Design and Biomimetics and the Milton Glick Professor in the School of Molecular Sciences.

Almost 99% of all human ancestors may have been wiped out around 930,000 years ago, a new paper has claimed.

The new research, published in the journal Science, used DNA from living people to suggest that humans went through a bottleneck, an event where populations shrink drastically. The paper estimates that as few as 1,300 humans were left for a period of around 120,000 years.

While the exact causes aren’t certain, the near-extinction has been blamed on Africa’s climate getting much colder and drier.

There’s a new COVID variant nicknamed “FLiRT.” Here’s what you need to know about the variant, including the symptoms.

Scientists have published the most detailed data set to date on the neural connections of the brain, which was obtained from a cubic millimeter of tissue sample.

A cubic millimeter of brain tissue may not sound like much. But considering that that tiny square contains 57,000 cells, 230 millimeters of blood vessels, and 150 million synapses, all amounting to 1,400 terabytes of data, Harvard and Google researchers have just accomplished something stupendous.

Led by Jeff Lichtman, the Jeremy R. Knowles Professor of Molecular and Cellular Biology and newly appointed dean of science, the Harvard team helped create the largest 3D brain reconstruction to date, showing in vivid detail each cell and its web of connections in a piece of temporal cortex about half the size of a rice grain.

Continue reading “Researchers publish largest-ever dataset of neural connections” »

A new, Yale-led study suggests that a range of respiratory viral infections—including COVID-19 and influenza—may be preventable or treatable with a generic antibiotic that is delivered to the nasal passageway.

A team led by Yale’s Akiko Iwasaki and former Yale researcher Charles Dela Cruz successfully tested the effectiveness of neomycin, a common antibiotic, to prevent or treat respiratory viral infections in animal models when given to the animals via the nose. The team then found that the same nasal approach—this time applying the over-the-counter ointment Neosporin—also triggers a swift immune response by interferon-stimulated genes (ISGs) in the noses of healthy humans.

The findings were published in the journal Proceedings of the National Academy of Sciences.

In what has become a familiar refrain when discussing artificial intelligence (AI)-enabled technologies, voice cloning makes possible beneficial advances in accessibility and creativity while also enabling increasingly sophisticated scams and deepfakes. To combat the potential negative impacts of voice cloning technology, the U.S. Federal Trade Commission (FTC) challenged researchers and technology experts to develop breakthrough ideas on preventing, monitoring and evaluating malicious voice cloning.

Ning Zhang, an assistant professor of computer science and engineering in the McKelvey School of Engineering at Washington University in St. Louis, was one of three winners of the FTC’s Voice Cloning Challenge announced April 8. Zhang explained his winning project, DeFake, which deploys a kind of watermarking for voice recordings. DeFake embeds carefully crafted distortions that are imperceptible to the human ear into recordings, making criminal cloning more difficult by eliminating usable voice samples.

“DeFake uses a technique of adversarial AI that was originally part of the cybercriminals’ toolbox, but now we’re using it to defend against them,” Zhang said. “Voice cloning relies on the use of pre-existing speech samples to clone a voice, which are generally collected from social media and other platforms. By perturbing the recorded audio signal just a little bit, just enough that it still sounds right to human listeners, but it’s completely different to AI, DeFake obstructs cloning by making criminally synthesized speech sound like other voices, not the intended victim.”

Unlike CAR-T-cell therapy, experimental CAR-NK treatments could potentially be used off-the-shelf against many cancers. But finding the right source of NK cells is vital.

Genes inherited from Denisovans, extinct human relatives, may help Papua New Guineans in the lowlands fight off infection, while mutations to red blood cells may help highlanders live at altitude.

Researchers have made a digital map showing a tiny chunk of a human brain in unprecedented detail.

Based on a brain tissue sample that had been surgically removed from a person, the map represents a cubic millimeter of brain—an area about half the size of a grain of rice. But even that tiny segment is overflowing with 1.4 million gigabytes of information—containing about 57,000 cells, 230 millimeters of blood vessels and 150 million synapses, the connections between neurons.

The researchers published their findings in the journal Science on Friday. They have made the data set freely available online and provided tools for analyzing and proofreading it.