Learn the key differences between cancer cells vs normal cells, including growth patterns, structure, and behavior, and how they impact cancer progression.
Category: biotech/medical – Page 48
A study reveals artificial hearts can regenerate heart muscle cells, supporting the idea that resting the heart enables healing.
Whether cells in the human body survive or die under stress depends, among other things, on their mitochondria. Scientists at the Faculty of Medicine at the University of Freiburg have now shown that a sudden stop in energy production in mitochondria prevents normal cell death or so-called apoptosis and instead triggers an inflammatory response. The results of this research were published in the journal Immunity.
“We found that mitochondria provide a kind of decision-making aid: they regulate whether a cell undergoes clean, silent apoptosis or releases pro-inflammatory messenger substances,” explains Prof. Dr. Olaf Groß, head of the study, a scientist at the Institute of Neuropathology at the Medical Center—University of Freiburg and a member of the Cluster of Excellence CIBSS—Center for Integrative Biological Signaling Studies at the University of Freiburg.
“This finding helps us to better understand how the body maintains a balance between cell protection and defense mechanisms. This could open up new avenues for the treatment of inflammatory diseases.”
Researchers discovered that the mRNA modification m6A triggers rapid degradation, regulating protein production. This breakthrough could inform drug development to manage protein-related diseases.
Messenger ribonucleic acids (mRNA) are like the architects of our bodies. They carry precise blueprints for building proteins, which are read and assembled by their cellular partners, the ribosomes. Proteins are essential for our survival, as they regulate cell division, bolster the immune system, and make our cells resilient against external threats.
Just like in real-world construction, some cellular blueprints require extra instructions—such as when a protein needs to be produced rapidly or when corrections are needed for a flawed design. In our bodies, this role is fulfilled by RNA modifications. These small chemical changes function like detailed annotations, offering additional guidance to specific parts of the mRNA for optimal protein production.
A study published in Cell Reports Medicine reveals that bowel movement frequency significantly influences physiology and long-term health, with the best outcomes linked with passing stools once or twice a day.
Previous research has suggested associations between constipation and diarrhea with higher risks of infections and neurodegenerative conditions, respectively.
But since these findings were observed in sick patients, it remained unclear whether irregular bathroom visits were the cause or result of their conditions.
Researchers at the University of Cincinnati College of Medicine and Cincinnati Children’s Hospital have developed a new approach, which combines advanced screening techniques with computational modeling, to significantly shorten the drug discovery process. It has the potential to transform the pharmaceutical industry.
The research, published recently in Science Advances, represents a significant leap forward in drug discovery efficiency. It was featured on LegalReader.com.
https://www.uc.edu/news/articles/2024/09/uc-college-of-medic…aster.html
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Elacestrant, also known as Korserdu, will be used to treat a specific kind of breast cancer.
Li, Y.; Hecht, S.S. Metabolic Activation and DNA Interactions of Carcinogenic N-Nitrosamines to Which Humans Are Commonly Exposed. Int. J. Mol. Sci. 2022, 23, 4559. https://doi.org/10.3390/ijms23094559
AMA Style
Li Y, Hecht SS. Metabolic Activation and DNA Interactions of Carcinogenic N-Nitrosamines to Which Humans Are Commonly Exposed. International Journal of Molecular Sciences. 2022; 23:4559. https://doi.org/10.3390/ijms23094559
Immunotherapy is a type of cancer treatment that stimulates a patient’s immune system to attack tumours.
While promising, its effectiveness varies among patients.
The new VUB technology helps identify in advance which patients are likely to benefit from this treatment.
The study introduces an innovative tracer targeting CD163, a molecular receptor on tumour-associated macrophages—immune cells that support tumour growth and protection.
DOI: Abstract We are living in a historical period in respect to the deterioration in public health, as we experience the rise of the catastrophic obesity epidemic and mental health crisis in recent decades, despite the great efforts from the scientific and medical community to seek health solutions and to try to find cures to the enormous human suffering and economic costs resulting by this collapse in public health. This trend has reached such a critical level that it jeopardizes society when over 40% of the population is obese in the United States, suffering grave medical health conditions, even as the expenditure on public health is rising exponentially to over 20% of gross domestic product. This should point to a monumental failure in our fundamental understanding of basic human biology and health. This article suggests that our current Western reductionist scientific paradigm in both biology and medicine has proved impotent and failed us completely. Therefore, the current cultural health crises require a more holistic approach to human biology and health in terms of chronobiological trends. The emerging neuroscience of brain energy metabolism will be considered as a holistic model for understanding how solar cycles affect our civilization and drive our sex and growth hormones and neurotransmitters that shape both our physical and mental health.