Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: biotech/medical – Page 45

Aging and chronic inflammation: impacts on olfactory dysfunction-a comprehensive review

Olfactory dysfunction (OD) is a common nasal disease, particularly prevalent among the elderly population, significantly impacting the affected individuals’ quality of life. This review focuses on the influence of aging and chronic inflammation on olfactory dysfunction, presenting insights from both the peripheral and central olfactory systems. By exploring the molecular mechanisms and pathological changes underlying the occurrence of olfactory dysfunction in relation to age-related diseases and chronic inflammation conditions, we aim to provide a comprehensive theoretical foundation for further research and offer valuable insights for more effective treatment of olfactory dysfunction.

One Stage of Sleep Seems Critical For Reducing Risk of Dementia

The risk of getting dementia may go up as you get older if you don’t get enough slow-wave sleep.

A 2023 study found that over-60s are 27 percent more likely to develop dementia if they lose just 1 percent of this deep sleep each year.

Slow-wave sleep is the third stage of a human 90-minute sleep cycle, lasting about 20–40 minutes. It’s the most restful stage, where brain waves and heart rate slow and blood pressure drops.

Biomarkers For Slowing Eye Aging, Featuring @DoctorEyeHealth

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links/Affiliates:
Blood testing (where I get the majority of my labs): https://www.ultalabtests.com/partners/michaellustgarten.

At-Home Metabolomics: https://www.iollo.com?ref=michael-lustgarten.
Use Code: CONQUERAGING At Checkout.

Clearly Filtered Water Filter: https://get.aspr.app/SHoPY

Epigenetic, Telomere Testing: https://trudiagnostic.com/?irclickid=U-s3Ii2r7xyIU-LSYLyQdQ6…M0&irgwc=1
Use Code: CONQUERAGING

NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/

Continue reading “Biomarkers For Slowing Eye Aging, Featuring @DoctorEyeHealth” | >

Nanoparticle-cell interface enables electromagnetic wireless programming of mammalian transgene expression

Recent technological advances are fueling the development of cutting-edge technologies that can monitor and control physiological processes with high precision. These include devices that could control the expression of genes within living organisms, without requiring invasive surgeries or procedures.

Researchers at ETH Zurich recently introduced a new method that enables the electromagnetic programming of the wireless expression regulation (EMPOWER) of transgenes in mammals, via the interfacing of and cells.

Their proposed approach, outlined in a paper published in Nature Nanotechnology, could help to treat , including diabetes, while also opening new possibilities for research in synthetic biology and regenerative medicine.

New Understanding of BRCA2 Mutation-Driven Mechanism Could Inform Anti-Cancer Drug Development

Inherited mutations in the gene BRCA2 significantly increase the risk of carriers to breast and ovarian cancers. BRCA2, a crucial player in the body’s DNA repair system, aids in repairing damaged DNA. This function is particularly intriguing as our cells constantly divide and replicate, passing on any genetic damage to newly developing cells.

Because of its significant role in maintaining genetic stability, BRCA2 belongs to a class of genes known as tumor suppressors. These genes code for proteins that control how often cells divide. However, when a tumor suppressor gene, such as BRCA2, undergoes a mutational change, the protein it codes for won’t function normally, resulting in uncontrolled cell division and, in some circumstances, cancer development.

BRCA2 predisposes carriers to cancer and research has shown that BRCA2-deficient tumors respond to therapies known as PARP inhibitors, which block the function of the poly ADP-ribose polymerase 1 (PARP1) protein. PARP1 becomes activated in tumors with BRCA2 mutations, resulting in the continued abnormal growth of damaged DNA.