New nanoparticles that enhance mRNA delivery could reduce vaccine dosage, costs, and possibly even side effects. “Our goal has been to try to make nanoparticles that can give you a safe and effective vaccine response but at a much lower dose,” Daniel Anderson says.
A new lipid nanoparticle could make mRNA vaccines more effective and potentially lower the cost per dose. New research suggests an mRNA influenza vaccine delivered with the new particle could generate the same immune response as mRNA delivered by standard nanoparticles, but at around 1/100 the dose.
Antibody-drug conjugates (ADCs) reflect a new promising approach in prostate cancer, even more so after the practice-changing results in other malignancies, either hematologic or solid. ADCs consist of monoclonal antibodies (mAb) targeted at specific antigens overly expressed on cancer cells compared to normal cells. A cytotoxic payload is attached to the mAb using a stable linker. In prostate cancer, PSMA, STEAP1, TROP2, CD46 and B7-H3 are antigens currently being studied as targets for ADCs. In this paper, we discuss the composition of ADCs and focus on their application and challenges as treatment options in prostate cancer.
Cancer therapy targeting acetylation and autophagy.
💡 Liu, Y., Yan, Z., Fu, Z. et al. Cell Death Discov. 11, 522 (2025).
💡 Liu, Y., Yan, Z., Fu, Z. et al. Crosstalk between acetylation modification and autophagy in cancer: roles: mechanisms and therapeutic potential. Acta Pharmacol Sin. 2024;46:816–28.
One of the world’s most common viral infections could underlie virtually every case of lupus, according to a recent study providing the strongest evidence yet for a link.
The research, led by scientists at Stanford University, has found that the Epstein-Barr virus (EBV) could be the trigger behind the ‘cruel mystery’
EBV is the pathogen that causes ‘kissing disease’ (or mononucleosis), and according to the new findings, it can directly infect and reprogram specific immune cells, potentially driving the onset of the chronic autoimmune disease systemic lupus erythematosus – better known as simply lupus.
Background and ObjectivesVascular dysfunction contributes to Alzheimer disease (AD) and related dementias (ADRDs), but the underlying mechanisms remain unclear. Previous studies link midlife hemostasis and platelet aggregation measures to late-life…
Damage in the bonding interface is a significant factor that leads to premature failure of dental bonded restorations. The imperfectly bonded dentin-adhesive interface is susceptible to hydrolytic degradation and bacterial and enzyme attack, severely jeopardizing restorations’ longevity. Developing caries around previously made restorations, also called “recurrent or secondary caries,” is a significant health problem. The replacement of restorations is the most prevailing treatment in dental clinics, leading to the so-called “tooth death spiral”. In other words, every time a restoration is replaced, more tooth tissue is removed, increasing the size of the restorations until the tooth is eventually lost. This process leads to high financial costs and detriment to patients’ quality of life.
Not every part of a DNA sequence gets translated into a protein. Each sequence consists of exons, which are included in the final RNA transcript, and introns, which are thrown away.
The expression of CD4 and CD8 co-receptors defines two distinct T cell populations with specialized functions. While CD4+ T cells support and modulate immune responses through different T-helper (Th) and regulatory subtypes, CD8+ T cells eliminate cells that might threaten the organism, for example, virus-infected or tumor cells. However, a paradoxical population of CD4+CD8+ double-positive (DP) T cells challenging this paradigm has been found in the peripheral blood. This subset has been observed in healthy as well as pathological conditions, suggesting unique and well-defined functions. Furthermore, DP T cells express activation markers and exhibit memory-like features, displaying an effector memory (EM) and central memory (CM) phenotype.
A series of focused interviews with the most interesting and impactful thought leaders in the field. We press on first principles—how they define core ideas in their domain, how they see the present, and where they believe intelligence is headed. Brought to you by SingularityNET and the AGI Society.
About this interview — Joscha Bach. In this kickoff episode, cognitive scientist Joscha Bach explores consciousness as a coherence-forming learning process, argues for a computational view of mind, and outlines why machine consciousness should be treated as a testable hypothesis rather than a slogan. He discusses the California Institute for Machine Consciousness, contrasts today’s “idiot-savant” AI with developmental intelligence, sketches futures from universal basic intelligence to post-human infospheres, and offers frank advice to new researchers on pursuing bold, technically grounded work.
SingularityNET was founded by Dr. Ben Goertzel with the mission of creating a decentralized, democratic, inclusive, and beneficial Artificial General Intelligence (AGI). An AGI is not dependent on any central entity, is open to anyone, and is not restricted to the narrow goals of a single corporation or even a single country.
The SingularityNET team includes seasoned engineers, scientists, researchers, entrepreneurs, and marketers. Our core platform and AI teams are further complemented by specialized teams devoted to application areas such as finance, robotics, biomedical AI, media, arts, and entertainment.
