Lifeboat Foundation

CRISPR was first discovered in bacteria as a defense mechanism, suggesting that nature hides a bounty of CRISPR components. For the past decade, scientists have screened different natural environments—for example, pond scum—to find other versions of the tool that could potentially increase its efficacy and precision. While successful, this strategy depends on what nature has to offer. Some benefits, such as a smaller size or greater longevity in the body, often come with trade-offs like lower activity or precision.

Rather than relying on evolution, can we fast-track better CRISPR tools with AI?

This week, Profluent, a startup based in California, outlined a strategy that uses AI to dream up a new universe of CRISPR gene editors. Based on large language models—the technology behind the popular ChatGPT—the AI designed several new gene-editing components.

Blood transfusions save lives. In the US alone, people receive around 10 million units each year. But blood banks are always short in supply—especially when it comes to the “universal donor” type O.

Surprisingly, the gut microbiome may hold a solution for boosting universal blood supplies by chemically converting other blood types into the universal O.

Infusing the wrong blood type—say, type A to type B—triggers deadly immune reactions. Type O blood, however, is compatible with nearly everyone. It’s in especially high demand following hurricanes, earthquakes, wildfires, and other crises because doctors have to rapidly treat as many people as possible.

Researchers develop a precise method for patterning gold nanoparticles on surfaces using DNA origami and electron beam lithography, enabling tunable plasmonic metasurfaces.

Discover bottom-up nanotechnology: precision construction of nanostructures for breakthroughs in medicine, electronics, and beyond.

Creating robots to safely aid disaster victims is one challenge; executing flexible robot control that takes advantage of the material’s softness is another. The use of pliable soft materials to collaborate with humans and work in disaster areas has drawn much recent attention. However, controlling soft dynamics for practical applications has remained a significant challenge.

In collaboration with the University of Tokyo and Bridgestone Corporation, Kyoto University has now developed a method to control pneumatic artificial muscles, which are soft robotic actuators. Rich dynamics of these drive components can be exploited as a computational resource.

Artificial muscles control rich soft component dynamics by using them as a computational resource. (Image: MEDICAL FIG.)

Blood test detects stroke quickly:

The Testing for Identification of Markers of Stroke trial shows the accuracy of a new blood test for identifying stroke.

A team of scientists has developed a new test by combining blood-based biomarkers with a clinical score. The main goal was to identify patients experiencing large vessel occlusion (LVO) stroke.

Continue reading “New rapid blood test can detect stroke in 6 hours, save lives” »

Our approach to analyzing and mitigating future risks posed by advanced AI models.

Google DeepMind has consistently pushed the boundaries of AI, developing models that have transformed our understanding of what’s possible. We believe that AI technology on the horizon will provide society with invaluable tools to help tackle critical global challenges, such as climate change, drug discovery, and economic productivity. At the same time, we recognize that as we continue to advance the frontier of AI capabilities, these breakthroughs may eventually come with new risks beyond those posed by present-day models.

Today, we are introducing our Frontier Safety Framework — a set of protocols for proactively identifying future AI capabilities that could cause severe harm and putting in place mechanisms to detect and mitigate them. Our Framework focuses on severe risks resulting from powerful capabilities at the model level, such as exceptional agency or sophisticated cyber capabilities. It is designed to complement our alignment research, which trains models to act in accordance with human values and societal goals, and Google’s existing suite of AI responsibility and safety practices.

In organisms, fluid is what binds the organs, the blood vessels and the musculoskeletal system as a whole. For example, hemolymph, a blood-like fluid in a spider’s body, enables muscle activation and exoskeleton flexibility. It was the cucumber spider inhabiting Estonia that inspired scientists to create a complex soft robot, where soft and rigid parts are made to work together and are connected by a liquid.

According to Indrek Must, Associate Professor of Soft Robotics, the designed soft robot is based on real reason. “Broadly speaking, our goal is to build systems from both natural and artificial materials that are as effective as in wildlife. The robotic leg could touch delicate objects and move in the same complex environments as a living spider,” he explains.

In a research paper published in the journal Advanced Functional Materials, the researchers show how a robotic foot touches a primrose stamen, spider web, and pollen grain. This demonstrates the soft robot’s ability to interact with very small and delicate structures without damaging them.

Sony has shown off its new surgical robot doing some super-precise work sewing up a tiny slit in a corn kernel. It’s the first machine of its kind that auto-switches between its different tools, and has successfully been tested in animal surgery.

It’s designed to help in the field of super-microsurgery, a highly specialized field in which surgeons operate on extremely small blood vessels and nerves, with diameters well under 1 mm (0.04 in). As you might imagine, this kind of thing requires incredibly steady hands, and specialists in this field often do their work whole looking through a microscope.

Continue reading “Watch: Sony’s new microsurgery robot stitches up a corn kernel” »