Mao, H., Tian, Y., Wang, Z. et al. Discovery and engineering of Tsp2Cas9 for genome editing. Cell Discov 10, 55 (2024). https://doi.org/10.1038/s41421-024-00685-w.
Theory of mind —the ability to understand other people’s mental states—is what makes the social world of humans go around. It’s what helps you decide what to say in a tense situation, guess what drivers in other cars are about to do, and empathize with a character in a movie. And according to a new study, the large language models (LLM) that power ChatGPT and the like are surprisingly good at mimicking this quintessentially human trait.
“Before running the study, we were all convinced that large language models would not pass these tests, especially tests that evaluate subtle abilities to evaluate mental states,” says study coauthor Cristina Becchio, a professor of cognitive neuroscience at the University Medical Center Hamburg-Eppendorf in Germany. The results, which she calls “unexpected and surprising,” were published today —somewhat ironically, in the journal Nature Human Behavior.
The results don’t have everyone convinced that we’ve entered a new era of machines that think like we do, however. Two experts who reviewed the findings advised taking them “with a grain of salt” and cautioned about drawing conclusions on a topic that can create “hype and panic in the public.” Another outside expert warned of the dangers of anthropomorphizing software programs.
“Neuralink to implant 2nd human with brain chip as 85% of threads retract. Neuralink’s first patient, 29-year-old Noland Arbaugh, opened up about the roller-coaster experience. ” I was on such a high and then to be brought down that low. It was very, very hard,” Arbaugh said. ” I cried.” What a disaster!
Algorithm tweaks made up for the loss, and Neuralink thinks it has fix for next patient.
How do you define consciousness?
Some theories are even duking it out in a mano-a-mano test by imaging the brains of volunteers as they perform different tasks in clinical test centers across the globe.
But unlocking the neural basis of consciousness doesn’t have to be confrontational. Rather, theories can be integrated, wrote the authors, who were part of the Human Brain Project —a massive European endeavor to map and understand the brain—and specialize in decoding brain signals related to consciousness.
Continue reading “Scientists Are Working Towards a Unified Theory of Consciousness” »
Nightmares and hallucinations could be early signs of autoimmune diseases like lupus, potentially improving early diagnosis and treatment, according to a new study.
An increase in nightmares and hallucinations – or ‘daymares’ – could indicate the beginning of autoimmune diseases such as lupus. This is according to an international team led by researchers at the University of Cambridge and King’s College London.
They emphasize the importance of recognizing these mental health and neurological symptoms as early warning signs of an impending ‘flare,’ a phase during which the disease intensifies temporarily.
In March, the United States reported its first detection of the highly pathogenic H5N1 avian influenza in dairy cattle, with outbreaks spreading to nine states by May. The transmission method among cattle remains unclear. However, a study published in the journal Nature Communications revealed that a similar H5N1 strain, subtype clade 2.3.4.4b, which previously caused an outbreak in farmed mink in 2022, was capable of airborne transmission to a small group of ferrets.
This is the first time that a member of the group of H5N1 clade 2.3.4.4b viruses has been shown to exhibit this ability. According to the Penn State researchers who led the study, the findings suggest these viruses are evolving to infect mammals and with potentially increased risk to humans.
“While there is no evidence that the strain of H5N1 that is presently affecting dairy cattle is capable of airborne transmission, our study suggests that another member of this family of viruses has evolved some degree of airborne transmissibility,” said Troy Sutton, associate professor of veterinary and biomedical sciences, Penn State, and corresponding author on the paper. “This finding underscores the importance of continued surveillance to monitor the evolution of these viruses and their spillover into other mammals, including humans.”
A large team of biomedical researchers affiliated with a host of institutions across the U.S., the U.K., Saudi Arabia and France, has learned more about many of the factors involved in xenotransplantation as they conducted a large number of tests on two brain-dead human patients that had received genetically engineered pig hearts.
A hormone already present in the human body could be used to stop Alzheimer’s disease in its tracks, scientists have announced.
Researchers discovered that a small part of an appetite-suppressing hormone called leptin, which is present in everyone, can have dramatic effects on the brain, including stopping the development of Alzheimer’s disease in its earliest stages.
Their tests have shown that leptin can reduce the effects of two toxic proteins in the brain called amyloid and tau, which build up and lead to memory loss and development of Alzheimer’s disease.
We acquired a rapidly preserved human surgical sample from the temporal lobe of the cerebral cortex. We stained a 1 mm3 volume with heavy metals, embedded it in resin, cut more than 5,000 slices at ∼30 nm and imaged these sections using a high-speed multibeam scanning electron microscope. We used computational methods to render the three-dimensional structure containing 57,216 cells, hundreds of millions of neurites and 133.7 million synaptic connections. The 1.4 petabyte electron microscopy volume, the segmented cells, cell parts, blood vessels, myelin, inhibitory and excitatory synapses, and 104 manually proofread cells are available to peruse online. Many interesting and unusual features were evident in this dataset. Glia outnumbered neurons 2:1 and oligodendrocytes were the most common cell type in the volume. Excitatory spiny neurons comprised 69% of the neuronal population, and excitatory synapses also were in the majority (76%). The synaptic drive onto spiny neurons was biased more strongly toward excitation (70%) than was the case for inhibitory interneurons (48%). Despite incompleteness of the automated segmentation caused by split and merge errors, we could automatically generate (and then validate) connections between most of the excitatory and inhibitory neuron types both within and between layers. In studying these neurons we found that deep layer excitatory cell types can be classified into new subsets, based on structural and connectivity differences, and that chandelier interneurons not only innervate excitatory neuron initial segments as previously described, but also each other’s initial segments. Furthermore, among the thousands of weak connections established on each neuron, there exist rarer highly powerful axonal inputs that establish multi-synaptic contacts (up to ∼20 synapses) with target neurons. Our analysis indicates that these strong inputs are specific, and allow small numbers of axons to have an outsized role in the activity of some of their postsynaptic partners.
The authors have declared no competing interest.
Patients with growth hormone receptor deficiency, or Laron syndrome, appear to have lower than average risk factors for cardiovascular disease, according to a new study.
A new study highlights possible cardiovascular health advantages in individuals with a rare condition known as growth hormone receptor deficiency (GHRD), also called Laron syndrome.
GHRD, which is characterized by the body’s impaired ability to use its own growth hormone and results in stunted growth, has been linked in mice to a record 40% longevity extension and lower risks for various age-related diseases. However, the risk of cardiovascular disease in individuals with GHRD has remained unclear until now, leading to the speculation that in people, this mouse longevity mutation may actually increase cardiovascular disease.
