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Category: biotech/medical – Page 35

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Imagine your lungs, those essential organs responsible for getting oxygen into your blood, suddenly tasked with a new job: making blood itself. It sounds almost unbelievable, right? For centuries, we’ve been taught that bone marrow is the powerhouse of blood production. Yet, a groundbreaking discovery has just turned that conventional wisdom upside down.

Researchers at the University of California, San Francisco, have found that our lungs do far more than help us breathe—they’re also busy creating millions of platelets every hour, playing an unexpected and crucial role in our blood supply. This discovery not only challenges what we thought we knew about the body but also opens the door to new possibilities in understanding blood production and its implications for human health.

Continue reading “Scientists Found an Unexpected Lung Function — Our Lungs Make Blood” | >

In a recent study, more than 90% of participants whose stomachs had been surgically removed to prevent cancer experienced a least one chronic complication 2 years out from their surgery. For some, the complications are life-altering.

Findings from a recent study will help clinicians counsel people who are considering preventive gastrectomy about the long-term impacts of the surgery.

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Exploiting an ingenious combination of photochemical (i.e., light-induced) reactions and self-assembly processes, a team led by Prof. Alberto Credi of the University of Bologna has succeeded in inserting a filiform molecule into the cavity of a ring-shaped molecule, according to a high-energy geometry that is not possible at thermodynamic equilibrium. In other words, light makes it possible to create a molecular “fit” that would otherwise be inaccessible.

“We have shown that by administering to an , a molecular self-assembly reaction can be prevented from reaching a thermodynamic minimum, resulting in a product distribution that does not correspond to that observed at equilibrium,” says Alberto Credi.

“Such a behavior, which is at the root of many functions in living organisms, is poorly explored in artificial because it is very difficult to plan and observe. The simplicity and versatility of our approach, together with the fact that visible light—i.e., sunlight—is a clean and sustainable energy source, allow us to foresee developments in various areas of technology and medicine.”

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Optical tweezers and related techniques provide extraordinary opportunities for research and applications in the physical, biological, and medical fields. However, certain requirements such as high-intensity laser beams, sophisticated electrode designs, additional electric sources, and low-conductive media, significantly impede their flexibility and adaptability, thus hindering their practical applications.

In a study published in The Innovation, a research team led by Dr. Du Xuemin from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences reported a novel photopyroelectric tweezer (PPT) that combines the advantages of the light and electric fields. The PPT enables versatile manipulation in various working scenarios.

The proposed PPT consists of two key components, a (NIR) spectrum laser light source and a PPT device that includes a liquid medium and a photopyroelectric substrate.

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The two professions associated with the lowest levels of death due to Alzheimer’s disease may be surprising.

Taxi and ambulance drivers were found to have the lowest proportion of deaths of more than 440 occupations that were considered in a new observation-based study from Massachusetts physicians.

Alzheimer’s disease is a type of dementia that affects memory, thinking, and behavior. It impacts millions of Americans and is one of the top 10 causes of death in the US.

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1 million plus cases of influenza in Japan this year. This needs to be investigated as it could cause another major pandemic.

Influenza is on the rise across Japan, with weekly case counts increasing in all 47 prefectures.

The National Institute of Infectious Diseases and other organizations say about 5,000 hospitals and clinics across the country reported seeing 211,049 flu patients in the seven-day period up to December 22.

That’s more than double the figure from the previous week.

Continue reading “Influenza cases on rise across Japan” | >

Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have developed the largest collection of sarcoma patient-derived organoids to date that can help improve the understanding of the disease and better identify therapies that are most likely to work for each individual patient.

The approach, detailed in the journal Cell Stem Cell, uses patients’ own tumor cells that replicate the unique characteristics of a patient’s tumor allowing scientists to quickly screen a large number of drugs in order to identify personalized treatments that can target this rare and diverse group of cancers.

“Sarcoma is a rare and complex disease, which makes conducting clinical trials to identify effective treatments particularly challenging. Some of the rarer subtypes lack standard treatment altogether. Even when multiple therapy options are available, there is often no reliable, data-driven method to determine the best course of action for an individual patient. Choosing the most effective treatment is akin to searching for a needle in a haystack,” said Dr. Alice Soragni, the senior author of the study and assistant professor in the department of Orthopaedic Surgery at the David Geffen School of Medicine at UCLA. “Testing drugs with patient-derived tumor organoids has potential to help predict how a patient may respond to treatment, with the goal of improving patient outcomes for diseases where treatment options are often limited.”

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For the first time, researchers used lab-grown organoids created from tumors of individuals with glioblastoma (GBM) to accurately model a patient’s response to CAR T cell therapy in real time. The organoid’s response to therapy mirrored the response of the actual tumor in the patient’s brain. That is, if the tumor-derived organoid shrunk after treatment, so did the patient’s actual tumor, according to new research from the Perelman School of Medicine, published in Cell Stem Cell.

Lab-grown tumors respond to cell therapy the same as tumors in the patients’ brains, according to researchers at Penn Medicine.

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