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Category: biotech/medical – Page 36

This Rare Fungus Can Kill Cancer Cells, And We Finally Know Its Secret

The rare Antrodia cinnamomea fungus (also known as Taiwanofungus camphoratus) is only found in Taiwan, and is associated with one particular type of endangered tree. Long used for herbal medicines, the fungus has now been linked to cancer-fighting capabilities through a specific kind of sugar molecule.

Researchers from the National Taiwan University and National Yang Ming Chiao Tung University in Taiwan discovered the link by focusing on a group of compounds produced by the fungus called sulfate polysaccharides (SPS).

SPS is a kind of sugar molecule known as a sulfated galactoglucan, which combines compounds of glucose, galactose, and sulfate into one molecule.

Scientists fed people a fat-filled milkshake — it disrupted blood flow to their brains within hours

A single indulgent meal may carry hidden risks. Scientists found that drinking a milkshake with 130 grams of fat impaired blood flow to the brain within hours, raising concerns about stroke, dementia, and how everyday diets shape brain health.

Transferrin receptor–targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA

Paper on a promising Alzheimer’s immunotherapy: engineered asymmetric anti-amyloid-β antibody with a transferrin receptor binding domain for crossing the blood-brain-barrier and a mutation which mitigates harmful side effects seen in past versions of this type of treatment. #immunotherapy #alzheimers

Amyloid-related imaging abnormalities (ARIA), side effects of anti-amyloid drugs seen in magnetic resonance imaging of the brain, are a major safety concern in patients with Alzheimer’s disease. We developed an antibody transport vehicle (ATV) targeting transferrin receptor (TfR) for brain delivery of anti-amyloid-β protein (anti-Aβ) using asymmetrical Fc mutations (ATVcisLALA) that mitigates TfR-related liabilities and retains effector function when bound to Aβ. Administration of ATVcisLALA:Aβ in mice exhibited broad brain distribution and enhanced parenchymal plaque target engagement. This biodistribution reduced ARIA-like lesions and vascular inflammation. Taken together, ATVcisLALA has the potential to improve the next generation of Aβ immunotherapy through enhanced biodistribution mediated by transport across the blood-brain barrier.

Prostate cancer vaccine research launched University of Surrey

In September 2025, The Prostate Project, a Guildford-based volunteer-led charity, will launch a £250,000 campaign to raise funds for a prostate cancer research project widely anticipated to be ‘game-changing’

Work has begun to develop a vaccine to prevent the return of prostate cancer in men who have undergone a radical prostatectomy, the surgical removal of the prostate. Cancer vaccines have become an exciting area of research in recent years, and this new treatment could potentially save the lives of more than 1,500 men each year in the UK alone.

The Prostate Project, based at the Stokes Centre for Urology at Royal Surrey County Hospital, has a proven track record of funding research and treatment of prostate cancer, raising more than £11 million since its formation in 1998.

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Scientists move toward developing vaccine against pathogenic Staphylococcus aureus

Antibiotics are the old medicine cabinet standby for treating infections caused by multidrug-resistant Staphylococcus aureus, but as antimicrobial resistance continues to mount globally, scientists say there’s a need for new strategies.

While vaccines are a potential answer, achieving an effective way to immunize against multidrug-resistant S. aureus has led scientists down dozens of blind alleys. Ten that looked promising in in recent years failed miserably in human clinical trials.

Now, scientists in China are investigating a way to sidestep the myriad problems that plagued vaccine investigators in the past by choosing not to target a whole antigen. Instead, they say, it’s time to home in on a critical “surface loop” as a vaccine target. The infinitesimal loop is located on the S. aureus antigen known as MntC.

AI tool targets RNA structures to unravel secrets of the dark genome

We mapped the human genome decades ago, but most of it is still a black box. Now, UNSW scientists have developed a tool to peer inside and what they find could reshape how we think about disease.

Your genome is the genetic map of you, and we understand almost none of it.

Our handle on the bits of the genome that tell the body how to do things (“make eyes blue,” “build ,” “give this person sickle cell anemia”) is OK, but there are vast areas of the genome that don’t appear to do anything.

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