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Category: biotech/medical – Page 37

A stunning first look at the viruses inside us

You are mostly but not entirely human. If we crunch the numbers, 8% of your genome actually comes from viruses that got stranded there. This viral detritus is a souvenir from our evolutionary past, a reminder that viruses have been with us from the very beginning.

Usually, this 8% of your DNA—the viral bits—are kept silent. Scientists call it part of the “dark matter” in your genome.

Now scientists at La Jolla Institute for Immunology (LJI) have published a first look at a key viral protein. In a study published in Science Advances, LJI researchers revealed the first three-dimensional structure of a protein from one of these ancient “human endogenous retroviruses (HERVs).”

Breathwork can induce altered states of consciousness linked with changes in brain blood flow

Breathwork while listening to music may induce a blissful state in practitioners, accompanied by changes in blood flow to emotion-processing brain regions, according to a study published in the open-access journal PLOS One by Amy Amla Kartar from the Colasanti Lab in the Department of Clinical Neuroscience at Brighton and Sussex Medical School, U.K., and colleagues.

These changes occur even while the body’s stress response may be activated and are associated with reporting reduced negative emotions.

The popularity of breathwork as a therapeutic tool for psychological distress is rapidly expanding. Breathwork practices that increase ventilatory rate or depth, accompanied by music, can lead to altered states of consciousness (ASCs) similar to those evoked by psychedelic substances.

MRI technology inspires quantum advancement with 2D materials

The same technology behind MRI images of injury or disease also powers nuclear magnetic resonance (NMR) spectroscopy, which is used to analyze biological molecules for research on diseases and therapeutics. While NMR spectroscopy produces valuable data about the structure of molecules, the resolution is too low to sense individual atoms.

Now, quantum researchers at Purdue University are advancing an approach that could improve the resolution of NMR spectroscopy to the atomic scale and may also have applications in developing quantum computing and quantum communications.

“Conventional NMR spectroscopy is limited to measuring large samples of molecules. We’re interested in developing technologies that can detect and analyze a ,” said Tongcang Li, professor of physics and astronomy in the College of Science and of electrical and computer engineering in the College of Engineering.

AI prescribes new electrolyte additive combinations for enhanced battery performance

Batteries, like humans, require medicine to function at their best. In battery technology, this medicine comes in the form of electrolyte additives, which enhance performance by forming stable interfaces, lowering resistance and boosting energy capacity, resulting in improved efficiency and longevity.

Finding the right electrolyte for a battery is much like prescribing the right medicine. With hundreds of possibilities to consider, identifying the best additive for each battery is a challenge due to the vast number of possibilities and the time-consuming nature of traditional experimental methods.

Researchers at the U.S. Department of Energy’s (DOE) Argonne National Laboratory are using models to analyze known electrolyte additives and predict combinations that could improve battery performance. They trained models to forecast key battery metrics, like resistance and energy capacity, and applied these models to suggest new additive combinations for testing.

World’s first: China doctors transplant pig lung into brain-dead man

World’s first pig lung transplant in brain-dead man lasts nine days in China.

In a medical first, a pig lung was transplanted into a brain-dead human, where it functioned for nine days.

Surgeons at Guangzhou Medical University, China, performed the cross-species lung transplantation.

The recipient, a 39-year-old man who had suffered a brain hemorrhage, received the left lung from a Chinese Bama Xiang pig that had undergone genetic modifications.

Study finds type 2 diabetes blood factors drive breast cancer aggression

People with type 2 obesity-driven diabetes tend to have more aggressive breast cancers, but no one knows exactly why. A new study by researchers at Boston University Chobanian & Avedisian School of Medicine and published in Communications Biology found that tiny particles in the blood, known as exosomes, which are altered by diabetes, can reprogram immune cells inside tumors, making them weaker and allowing the cancer to grow and spread more easily.

“This is the first study to directly link exosomes from people with type 2 diabetes to suppressed inside human breast tumors,” said corresponding author Gerald Denis, Ph.D., the Shipley Prostate Cancer Research Professor at BU.

In the study, researchers used samples from to grow 3D tumor models in the lab. Known as patient-derived organoids, these models contain the originally found in the tumor. These mini-tumors were treated with blood exosomes from people with and without diabetes but also without any cancer. The researchers analyzed the organoids using single-cell RNA sequencing to see how the exosomes affected the immune cells and the tumor itself.

Cognitive behavioral therapy can alter brain structure and boost gray matter volume, study shows

Psychotherapy leads to measurable changes in brain structure. Researchers at Martin Luther University Halle-Wittenberg (MLU) and the University of Münster have demonstrated this for the first time in a study in Translational Psychiatry by using cognitive behavioral therapy.

The team analyzed the brains of 30 patients suffering from acute depression. After therapy, most of them showed changes in areas responsible for processing emotions. The observed effects are similar to those already known from studies on medication.

Around 280 million people suffer from worldwide. This depression leads to changes in the brain mass of the anterior hippocampus and amygdala. Both areas are part of the limbic system and are primarily responsible for processing and controlling emotions. In , (CBT) is an established method for treating depression.

Fresh insights into the inner workings of the developing brain could lead to autism treatments

While there is a vast amount of information about the human brain and how it develops and works, much of the organ is still uncharted territory. But new research published in the journal Nature is giving us new insights into a type of brain cell called the GABAergic interneuron and its role in the developing brain. These findings could help explain how conditions like autism and brain disorders in children develop.

GABAergic interneurons are a vital part of the brain. They release the neurotransmitter gamma-aminobutyric acid (GABA), which regulates by switching neurons on and off. Disruptions in their functions can lead to a number of disorders, including epilepsy, schizophrenia and autism.

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