For centuries, we’ve ignored the interstitium, but research is now revealing that this body-wide network of fluid is instrumental to our health and points the way to new treatments
Category: biotech/medical – Page 36
Lung cancer patient became tumourfree after treatment with selenite
A patient with advanced, treatment-resistant lung cancer became tumour-free after treatment with the selenium compound selenite. This is shown in a new study from Karolinska University Hospital and Karolinska Institutet published in the journal Oncology and Therapy as a case report. The findings may contribute to increased knowledge about selenite as a possible cancer treatment.
Psychedelic exposure during adolescence disrupts a brain circuit linked to lasting social avoidance in rats
Psychedelics, drugs that alter people’s perceptions, mood and thoughts, have recently shown promise for the treatment of some psychiatric disorders. Yet many psychedelic drugs remain controlled substances in most countries worldwide.
Despite these restrictions, national surveys suggest that millions of people use psychedelics in the United States. Moreover, many people reported that they first used these substances in adolescence, the sensitive developmental stage between childhood and adulthood, when brain circuits are still maturing.
Researchers at Ningbo University and its affiliated hospitals recently studied rats to better understand how repeated exposure to the psychedelic compound 25C-NBOMe during adolescence could influence brain activity and social behavior in adulthood.
Myeloproliferative Neoplasms
Classic myeloproliferative neoplasms, including essential thrombocythemia, polycythemia vera, and primary myelofibrosis, are chronic, clonal hematopoietic stem-cell disorders. These disorders are driven by gain-of-function mutations in the genes Janus kinase 2 (JAK2), calreticulin (CALR), or the thrombopoietin receptor (MPL) that activate cytokine signaling. These mutations arise decades before clinical disease develops and confer a clonal advantage that is further shaped by comutations in epigenetic, splicing, or signaling genes. Inflammation enhances clonal dominance, favoring the development of myelofibrosis and thrombotic complications. Disease evolution may culminate in secondary acute myeloid leukemia, which has a poor prognosis.
Study suggests 40Hz sensory stimulation may benefit some Alzheimer’s patients for years
A new research paper documents the outcomes of five volunteers who continued to receive 40Hz light and sound stimulation for around two years after participating in an MIT early-stage clinical study of the potential Alzheimer’s disease (AD) therapy. The results show that for the three participants with late-onset Alzheimer’s disease, several measures of cognition remained significantly higher than comparable Alzheimer’s patients in national databases. Moreover, in the two late-onset volunteers who donated plasma samples, levels of Alzheimer’s biomarker tau proteins were significantly decreased.
The three volunteers who experienced these benefits were all female. The two other participants, each of whom were males with early-onset forms of the disease, did not exhibit significant benefits after two years. The dataset, while small, represents the longest-term test so far of the safe, noninvasive treatment method (called GENUS, for gamma entrainment using sensory stimuli), which is also being evaluated in a nationwide clinical trial run by MIT-spinoff company Cognito Therapeutics.
“This pilot study assessed the long-term effects of daily 40Hz multimodal GENUS in patients with mild AD,” the authors wrote in an open-access paper in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. “We found that daily 40Hz audiovisual stimulation over 2 years is safe, feasible, and may slow cognitive decline and biomarker progression, especially in late-onset AD patients.”
Mitochondrial Transplantation Rejuvenates Immune Cells
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Are We Entering the Longevity Singularity? | Natasha Vita-More
Could AI and biology trigger a longevity singularity? Dr. Natasha Vita-More maps the AI-biology longevity flywheel and three frontiers reshaping longevity culture: nanorobots, biostasis, and AI prosthetics.
OFFICIAL WEBSITE:
https://www.natashavita-more.com/
As longevity grows from a scientific movement into a global industry and cultural force, Natasha presents her Three Frontiers of Longevity Culture:
• Nanorobots — precision repair, sensing, and therapeutic delivery at the cellular scale.
• Biostasis — preserving cells, tissues, organs, and potentially more complex biological systems.
• AI prosthetics — intelligent, adaptive technologies moving from restored function toward expanded human capability.
We separate what is possible today from what is experimental and what remains a long-term vision. How close are we to medical nanorobots? Could organ banking become the bridge to human biostasis? When does an intelligent prosthetic stop being a tool and begin becoming part of the person?
The conversation also examines the AI–biology longevity flywheel: how artificial intelligence could accelerate biological discovery, diagnostics, drug development, personalized interventions, regenerative medicine, and the broader effort to extend healthy human life.
Jacob Ward on The Loop, AI, and a World Without Real Choices
I recorded this conversation ten months ago. It has aged into something closer to a warning label.
Jacob Ward wrote The Loop before ChatGPT made his argument obvious. His claim: AI is doing to our decision-making what Google Maps did to our sense of direction. You never notice the skill leaving. You notice, one day, that you cannot get home without the phone.
So I asked him what I thought was a simple question. What is a choice?
Jake’s answer took the rest of the hour, and it starts somewhere uncomfortable. He describes a dinner with addiction scientists, people who study compulsion for a living, hired by consumer app companies. Not to cure anything. To calibrate.
From there we got into the decisions we have already handed over without a vote: hiring, lending, bail, custody, welfare. Hard moral calls outsourced to systems nobody in the room can inspect, because the human version was exhausting and the machine version is fast and cheap.
He is not a doomer, which is why the conversation lands. He thinks the fight for #FreeWill is still winnable, and he pointed to two pieces of evidence I did not expect: teenagers calling AI “clankers,” and the return of film cameras.
