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Category: biotech/medical – Page 36

Spleen-based islet transplantation restores glycemic control in type 1 diabetes without full immunosuppression

Wenzhou Medical University researchers have reimagined the spleen as a viable site for islet transplantation, enabling long-term diabetes control without the burden of full immunosuppression. Nanoparticle-driven spleen remodeling allowed transplanted mouse, rat, and human islets to restore normal blood sugar in diabetic rodents and cynomolgus macaques.

In type 1 diabetes, the immune system destroys native beta cells, the housed within pancreatic clusters called islets of Langerhans. Islet transplantation transfers these clusters from donor pancreases into the portal vein of the recipient’s liver, where they settle in the hepatic microvasculature. Once in place, they resume insulin secretion to reduce or eliminate injections and restore .

Liver-based transplantation has significant drawbacks. Immune attack, low oxygen tension, and the rigidity of hepatic tissue often destroy most transplanted islets within hours. Upward of 70% of cells are destroyed before engraftment, forcing reliance on multiple donors per recipient and blunting therapeutic success.

Surprise Link Between Menthol And Alzheimer’s Found in Mice

In recent years, scientists discovered something strange: When mice with Alzheimer’s disease inhale menthol, their cognitive abilities improve.

It seems the chemical compound can stop some of the damage done to the brain that’s usually associated with the disease.

In particular, researchers noticed a reduction in the interleukin-1-beta (IL-1β) protein, which helps to regulate the body’s inflammatory response – a response that can offer natural protection but one that leads to harm when it’s not controlled properly.

How you could see inside your body — with a micro-robot

Would you swallow a micro-robot? In a gutsy demo, physician Vivek Kumbhari navigates Pillbot, a wireless, disposable robot swallowed onstage by engineer Alex Luebke, modeling how this technology can swiftly provide direct visualization of internal organs. Learn more about how micro-robots could move us past the age of invasive endoscopies and open up doors to more comfortable, affordable medical imaging. (This talk contains medical imagery.)

Heart rhythm disorder traced to bacterium lurking in gums

Tempted to skip the floss? Your heart might thank you if you don’t. A new study from Hiroshima University (HU) finds that the gum disease bacterium Porphyromonas gingivalis (P. gingivalis) can slip into the bloodstream and infiltrate the heart. There, it quietly drives scar tissue buildup—known as fibrosis—distorting the heart’s architecture, interfering with electrical signals, and raising the risk of atrial fibrillation (AFib).

Clinicians have long noticed that people with periodontitis, a common form of gum disease, seem more prone to cardiovascular problems. One recent meta-analysis has linked it to a 30% higher risk of developing AFib, a potentially serious heart rhythm disorder that can lead to stroke, heart failure, and other life-threatening complications.

Globally, AFib cases have nearly doubled in under a decade, rising from 33.5 million in 2010 to roughly 60 million by 2019. Now, scientific curiosity is mounting about how gum disease might be contributing to that surge.

Breakthrough DNA-based supercomputer runs 100 billion tasks at once

The boundaries of computing are shifting as biology fuses with technology. At the center of this new frontier is an emerging concept: a liquid computer powered by DNA. With the ability to support more than 100 billion unique circuits, this system could soon transform how we detect and diagnose disease.

While DNA is best known for encoding life, researchers are now exploring its potential as a computing tool. A team led by Dr. Fei Wang at Shanghai Jiao Tong University believes DNA can do much more than carry genetic instructions.

Their study, recently published in Nature, reveals how DNA molecules could become the core components of new computing systems. Rather than just holding genetic data, DNA could behave like wires, instructions, or even electrons inside biological circuits.

Ketamine’s Antidepressant Action Extended for the First Time

Roughly 10 percent of the U.S. population is afflicted with major depressive disorder at any given time, and up to 20 percent will exhibit MDD symptoms over their lifetimes. Yet despite its prevalence, methods to treat MDD often fall short for a not-insignificant portion of the population. Antidepressants—the standard of treatment—don’t work for 30 percent with MDD.

When infused at a low dose, ketamine shows remarkable efficacy as a rapidly acting antidepressant, with effects observed within hours even in patients who have been resistant to other antidepressant treatments. However, consistent infusions of ketamine are needed to maintain symptoms at bay, which could result in side effects, such as dissociative behaviors and the possibility of addiction, and stopping treatment can result in relapse.

In a new study published in Science, Lisa Monteggia’s and Ege Kavalali’s labs show that it is feasible to substantially extend the efficacy of a single dose of ketamine from its current duration of up to a week to a longer period of up to two months.