Within a large group of more than 700 patients treated with CAR T cell therapy, researchers found no evidence that the therapy itself caused any type of secondary cancer in the modified T cells, according to new analysis reported today in Nature Medicine from the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine’s Abramson Cancer Center.
A major international study reveals that most people with cardiovascular disease.
Cardiovascular disease (CVD) encompasses a range of disorders affecting the heart and blood vessels, including coronary artery disease, heart attack, stroke, and hypertension. These conditions are primarily driven by atherosclerosis, a process where plaque builds up in the arterial walls, leading to narrowed or blocked arteries. Risk factors include smoking, unhealthy diet, lack of exercise, obesity, and genetic predisposition. CVD remains a leading cause of global mortality, emphasizing the importance of lifestyle changes, medical interventions, and preventive measures in managing and reducing the risk of heart-related illnesses.
The future of medicine may very well lie in the personalization of health care—knowing exactly what an individual needs and then delivering just the right mix of nutrients, metabolites, and medications, if necessary, to stabilize and improve their condition. To make this possible, physicians first need a way to continuously measure and monitor certain biomarkers of health.
To that end, a team of Caltech engineers has developed a technique for inkjet printing arrays of special nanoparticles that enables the mass production of long-lasting wearable sweat sensors. These sensors could be used to monitor a variety of biomarkers, such as vitamins, hormones, metabolites, and medications, in real time, providing patients and their physicians with the ability to continually follow changes in the levels of those molecules.
Wearable biosensors that incorporate the new nanoparticles have been successfully used to monitor metabolites in patients suffering from long COVID and the levels of chemotherapy drugs in cancer patients at City of Hope in Duarte, California.
Researchers at the University of Kentucky are exploring new ways to use nanoparticles in combination with other materials as an innovative approach to cancer therapy.
The paper titled “Iron Oxide Nanozymes Enhanced by Ascorbic Acid for Macrophage-Based Cancer Therapy” was published earlier this year in Nanoscale.
Sheng Tong, Ph.D., an associate professor in the F. Joseph Halcomb II, M.D., Department of Biomedical Engineering in the UK Stanley and Karen Pigman College of Engineering, led the study.
If you have ever had your blood drawn, whether to check your cholesterol, kidney function, hormone levels, blood sugar, or as part of a general checkup, you might have wondered why there is not an easier, less painful way.
Now there might be. A team of researchers from Caltech’s Cherng Department of Medical Engineering has unveiled a new wearable sensor that can detect in human sweat even minute levels of many common nutrients and biological compounds that can serve as indicators of human health.
The sensor technology was developed in the lab of Wei Gao, assistant professor of medical engineering, Heritage Medical Research Institute investigator, and Ronald and JoAnne Willens Scholar. For years, Gao’s research has focused on wearable sensors with medical applications, and this latest work represents the most precise and sensitive iteration yet.
Attention-deficit hyperactivity disorder (ADHD) is a well-known neurodevelopmental disorder that affects the brain’s ability to regulate attention and control impulses. It poses many challenges to those affected, typically making it difficult for them to sustain focus, follow through with instructions, and maintain a calm and restful state.
As one of the most common neurodevelopmental disorders, ADHD impacts individuals throughout their lives, creating a breadth of social, emotional, academic, and workplace challenges.
Despite its high prevalence and decades of research, currently available drugs for ADHD are not able to completely resolve the core symptoms of the disorder in most cases.
Tissue engineering utilizes 3D printing and bioink to grow human cells on scaffolds, creating replacements for damaged tissues like skin, cartilage, and even organs. A team of researchers led by Professor Insup Noh from Seoul National University of Science and Technology, Republic of Korea, has developed a bioink using nanocellulose derived from Kombucha SCOBY (Symbiotic Culture of Bacteria and Yeast) as the scaffold material.
The biomaterial offers a sustainable alternative to conventional options, and it can be loaded onto a hand-held “Biowork” biopen, also developed by the same team. The digital biopen allows the precise application of bioink to damaged defected areas, such as irregular cartilage and large skin wounds, paving the way for more personalized and effective in vivo tissue repair, eliminating the need for in vitro tissue engineering processes.
This paper was published in the International Journal of Biological Macromolecules on 1 December 2024.
The development of biomaterials for artificial organs and tissues is an active area of research due to increases in accidental injuries and chronic diseases, along with the entry into a super-aged society. 3D bioprinting technology, which uses cells and biomaterials to create three-dimensional artificial tissue structures, has recently gained popularity. However, commonly used hydrogel-based bioinks can cause cytotoxicity due to the chemical crosslinking agent and ultraviolet light that connect the molecular structure of photocuring 3D-printed bioink.
Dr. Song Soo-chang’s research team at the Center for Biomaterials, Korea Institute of Science and Technology (KIST), revealed the first development of poly(organophosphazene) hydrogel-based temperature-sensitive bioink that stably maintained its physical structure by temperature control only without photocuring, induced tissue regeneration, and then biodegraded in the body after a certain period of time.
Current hydrogel-based bioinks must go through a photocuring process to enhance the mechanical properties of the 3D scaffold after printing, with a high risk of adverse effects in the human body. In addition, there has been a possibility of side effects when transplanting externally cultured cells within bioink to increase the tissue regeneration effect.
Biological systems come in all shapes, sizes and structures. Some of these structures, such as those found in DNA, RNA and proteins, are formed through complex molecular interactions that are not easily duplicated by inorganic materials.
A research team led by Richard Robinson, associate professor of materials science and engineering, discovered a way to bind and stack nanoscale clusters of copper molecules that can self-assemble and mimic these complex biosystem structures at different length scales. The clusters provide a platform for developing new catalytic properties that extend beyond what traditional materials can offer.
The nanocluster core connects to two copper caps fitted with special binding molecules, known as ligands, that are angled like propeller blades.
RUDN chemists have synthesized metal complexes on the basis of the organoelemental substance silsesquioxane that consists of an organic and an inorganic part. Such hybrid systems may be used as efficient catalysts, for example, to obtain alcohols from alkanes. The work was published in the Inorganic Chemistry journal.
Physical and chemical parameters of any material or substance are limited and cannot be infinitely improved. So scientists work on hybrid materials that combine different components and therefore demonstrate new properties. In modern chemistry, special attention is paid to compounds that consist of metal centers and organic “bridges” that keep them together. Such objects have a number of valuable properties and may be used for industrial purposes: catalysis, storage of gases, accurate separation of mixed substances. They can also be used to create chemical sensors and agents to deliver drugs to their targets in the body.
Hybrid organoelemental substances such as silsesquioxanes consist of an inorganic main chain Si-O-Si and an organic framework of Si atoms. Compounds like this can be formed when metal atoms are added to carcass structures with promising catalytic and magnetic properties. RUDN chemists suggested a new approach to such compounds based on the use of additional complex-forming substances (ligands).