With aging, somatic mutations accumulate in cellular DNA; however, whether they drive age-related functional decline is incompletely understood. Here the authors show that these mutations can weaken muscle repair and reduce strength after injury, suggesting they play a role in age-related physical decline in mouse muscle.
Introduction Early detection of cardiovascular disease in primary care is a public health priority, for which the clinical and cost-effectiveness of an artificial intelligence-enabled stethoscope that detects left ventricular systolic dysfunction, atrial fibrillation and cardiac murmurs is unproven but potentially transformative.
Methods and analysis TRICORDER is a pragmatic, two-arm, multi-centre (decentralised), cluster-randomised controlled trial and implementation study. Up to 200 primary care practices in urban North West London and rural North Wales, UK, will be randomised to usual care or to have artificial intelligence-enabled stethoscopes available for use. Primary care clinicians will use the artificial intelligence-enabled stethoscopes at their own discretion, without patient-level inclusion or exclusion criteria.
The rare Antrodia cinnamomea fungus (also known as Taiwanofungus camphoratus) is only found in Taiwan, and is associated with one particular type of endangered tree. Long used for herbal medicines, the fungus has now been linked to cancer-fighting capabilities through a specific kind of sugar molecule.
Researchers from the National Taiwan University and National Yang Ming Chiao Tung University in Taiwan discovered the link by focusing on a group of compounds produced by the fungus called sulfate polysaccharides (SPS).
SPS is a kind of sugar molecule known as a sulfated galactoglucan, which combines compounds of glucose, galactose, and sulfate into one molecule.
Ann Johnson became paralyzed after a brainstem stroke at age 30. As a participant in a clinical trial led by researchers at UC Berkeley and UC San Francisco, she finally heard her voice again.
Paper on a promising Alzheimer’s immunotherapy: engineered asymmetric anti-amyloid-β antibody with a transferrin receptor binding domain for crossing the blood-brain-barrier and a mutation which mitigates harmful side effects seen in past versions of this type of treatment. #immunotherapy #alzheimers
Amyloid-related imaging abnormalities (ARIA), side effects of anti-amyloid drugs seen in magnetic resonance imaging of the brain, are a major safety concern in patients with Alzheimer’s disease. We developed an antibody transport vehicle (ATV) targeting transferrin receptor (TfR) for brain delivery of anti-amyloid-β protein (anti-Aβ) using asymmetrical Fc mutations (ATVcisLALA) that mitigates TfR-related liabilities and retains effector function when bound to Aβ. Administration of ATVcisLALA:Aβ in mice exhibited broad brain distribution and enhanced parenchymal plaque target engagement. This biodistribution reduced ARIA-like lesions and vascular inflammation. Taken together, ATVcisLALA has the potential to improve the next generation of Aβ immunotherapy through enhanced biodistribution mediated by transport across the blood-brain barrier.
In September 2025, The Prostate Project, a Guildford-based volunteer-led charity, will launch a £250,000 campaign to raise funds for a prostate cancer research project widely anticipated to be ‘game-changing’
Work has begun to develop a vaccine to prevent the return of prostate cancer in men who have undergone a radical prostatectomy, the surgical removal of the prostate. Cancer vaccines have become an exciting area of research in recent years, and this new treatment could potentially save the lives of more than 1,500 men each year in the UK alone.
The Prostate Project, based at the Stokes Centre for Urology at Royal Surrey County Hospital, has a proven track record of funding research and treatment of prostate cancer, raising more than £11 million since its formation in 1998.
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