Board-certified family physician Dr. Gabrielle Lyon discusses groundbreaking anti-aging research during ‘America’s Newsroom,’ including a gene therapy that could reverse biological aging.
Category: biotech/medical – Page 42
Dell CEO Michael Dell makes one of largest public university donations in US history, ‘gifts’ $750 million to the University of …
Dell CEO Michael Dell has donated $750 million to the University of Texas at Austin, marking one of the largest donations ever made to a public university in the United States. The gift will help fund a new healthcare and research campus, including what the university describes as the country’s first artificial intelligence-native hospital.
The Future of Neuroscience Is Growing and Reviving Human Brains
Further Reading.
Thumbnail image credit: Not alive, but not dead… FEATURED SCIENCE ARTICLE.
Brain background: Nexorg.
Brain organoid images: Elke Gabriel.
Not alive, but not dead: disembodied human brains used for drug testing.
https://www.science.org/content/artic…
Restoration of brain circulation and cellular functions hours.
https://pubmed.ncbi.nlm.nih.gov/30996…
Vascularizing organoids-on-chip for perfused and personalized models.
https://pubs.rsc.org/en/content/artic…
Startup Testing Drugs on Freshly Extracted Human Brains That Are Kept On Life Support.
https://futurism.com/health-medicine/.…
Cerebral organoids transplantation repairs infarcted cortex and restores impaired function after stroke https://www.nature.com/articles/s4153…
World First: Patient Receives High-Risk Therapy to Make Cells Young Again
An eagerly awaited and controversial clinical trial to ‘wind back the clock’ on aging cells in the eye and restore them to a more youthful state has officially begun.
This week, the United States biotechnology company Life Biosciences, Inc. announced that it had dosed its first patient with an experimental therapy designed to reverse age-related vision loss.
The ambitious idea is to turn back aging by activating three genes in retinal ganglion cells, which connect the brain to the eyes.
Bacteria reveal ‘glue’ protein that fastens antibiotic-resistant outer membrane to cell wall
Researchers at the University of Notre Dame and collaborators have discovered a key process in how the outer membrane of gram-negative bacteria attaches to the cell wall, advancing the understanding of how these bacteria frequently develop resistance to antibiotics.
The research, published in the Journal of the American Chemical Society, was carried out in the laboratory of Shahriar Mobashery, Navari Professor of Life Sciences in the Department of Chemistry and Biochemistry, with structural aspects of the study performed by Juan A. Hermoso of the Institute of Physical Chemistry “Blas Cabrera” in Madrid, Spain. The researchers discovered that the protein PA2854 performs the reaction that keeps the outside layers, or envelope, of gram-negative bacteria connected to each other.
Mobashery and collaborators studied the process in Pseudomonas aeruginosa (P. aeruginosa), a ubiquitous antibiotic-resistant bacterium commonly affecting people with cystic fibrosis. P. aeruginosa, like other gram-negative bacteria including E. coli, Klebsiella pneumoniae and Salmonella, is shielded by a three-layer biological envelope that prevents many antibiotics from penetrating and damaging the bacteria. Gram-positive bacteria do not have an outer membrane and are generally more susceptible to antibiotics.
Clinician–scientists identify brain network linked to deadliest childhood brain cancer
A human brain network associated with survival in children with diffuse midline glioma (DMG), the deadliest childhood brain cancer, has been identified by UCL clinician-scientists, raising the possibility of entirely new treatment approaches. The researchers found that DMG tumors seem to exploit the brain’s existing neural circuitry to drive tumor growth and progression. Tumors that were more strongly connected to this network were associated with significantly shorter patient survival.
The study, published in Nature, builds on pioneering work in the field of cancer neuroscience, which shows that brain tumors, including DMG, dynamically interact with the otherwise healthy brain.
The study was led by Dr. Jai Sidpra and Dr. Valentina Lind, medical students enrolled in the MBPhD Program within the UCL Division of Medicine and senior author Professor Darren Hargrave’s group at the UCL Great Ormond Street Institute of Child Health.
A ‘Useless’ Organ That Doctors Often Remove May Actually Fight Cancer
There’s a small fatty gland that sits behind your sternum and is often said to be ‘useless’ in adulthood.
Research, however, suggests the thymus gland is not nearly as expendable as experts once thought.
Although not all scientists agree on this.
In a study in 2023, US researchers found that those who get their thymus removed face an increased risk of death from any cause in the five years following the surgery.
New imaging technique measures single scramblase proteins, revealing lipid transport rates
A new single-protein analysis technique gives researchers an unprecedented ability to study proteins called scramblases, which have critical roles in biology. The development of the new technique, in a study led by investigators at Weill Cornell Medicine and Ruhr University Bochum in Germany, expands the toolkit available to cell biologists and biophysicists and could someday be useful in devising new strategies against multiple diseases.
Scramblases operate within cell membranes to rearrange the fat-related molecules, known as lipids, that make up those membranes. Their disruption of the usual layered organization of the membrane is essential for many important biological processes. In the study, published in Nature Structural & Molecular Biology, the researchers developed a fluorescence imaging-based technique—the first of its kind—for measuring the activity rates of individual scramblase proteins. Their demonstrations of the technique uncovered new findings on key scramblases and showcased the technique’s broad applicability.
“I’m excited about this new platform as it is versatile and provides unprecedented information on exactly how fast a single scramblase works,” said study co-senior author Dr. Anant Menon, professor of biochemistry and biophysics at Weill Cornell Medicine.