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Long-term outcomes and late effects of surgery and radiotherapy in adult intracranial ependymoma patients

To evaluate progression-free survival (PFS), overall survival (OS), local control (LC), and radiotherapy-related toxicities in the treatment of adult intracranial ependymoma.

A retrospective analysis was performed of WHO grade 2–3 adult intracranial ependymoma patients (≥ 18 years) treated with surgery alone or surgery and adjuvant radiotherapy between 2000 and 2024. Kaplan-Meier analyses were used to estimate PFS and OS. Acute and late treatment-related toxicities were characterized.

Fifty-eight patients met the inclusion criteria. Median age was 39 years (interquartile range [IQR] 25–51), and median follow-up was 51 months (IQR 23–103). Overall, 76% were WHO grade 2, 74% had posterior fossa location, gross total resection was achieved in 60%, 88% received adjuvant local radiotherapy, and 5% received adjuvant chemotherapy. Five and 10-year PFS rates were 80% and 64%, respectively; 5 and 10-year OS rates were 92% and 85%, respectively. There were 13 (22%) recurrences: The location of first failure was local in nine, distant in two, and both local and distant in two. The 5-year LC rate was 82% (95% CI 67–90%), and the 10-year LC rate was 72% (95% CI 53–84%). The median time to local failure was 5.4 years. Ten (22%) patients experienced at least one grade ≥ 2 late treatment-related toxicity. One potential secondary glioma (grade 5) occurred after nine years.

Blood biomarkers could measure response to psychotherapy in patients with depression

Research by the Barcelona Institute for Biomedical Research (IIBB), part of the Spanish National Research Council (CSIC), and the Institut de Recerca Sant Pau (IR Sant Pau) provides some of the first evidence that psychological therapies act as biological stimuli that induce molecular responses measurable through blood biomarkers.

The preliminary study, involving 22 patients with major depressive disorder at Hospital de Sant Pau, reveals that psychotherapy sessions trigger changes in microRNAs—molecules that regulate gene expression in cells—associated with significant improvements in the participants’ cognitive status. The results, published in Scientific Reports, represent an advance toward monitoring patients’ responses to pharmacological treatments and nonpharmacological therapeutic interventions.

The study, led by Dr. Maria J. Portella (IR Sant Pau) and Dr. Analia Bortolozzi (IIBB-CSIC), with Lluís Miquel-Rio (IIBB-CSIC) and Dr. Muriel Vicent-Gil (Hospital de Sant Pau) as first authors, focused on major depressive disorder (MDD). This condition is characterized not only by its effects on mood but also by a broad spectrum of cognitive impairments, including difficulties with attention, memory, processing speed and executive function. These symptoms frequently persist despite treatment and severely affect patients’ quality of life.

New tool helps uncover rare genetic mutations in common diseases, including Parkinson’s

Studies of genetics conducted in yeast cells, human neurons, mice or other model systems often reveal networks of genes that could contribute to complex diseases, such as breast cancer, type 2 diabetes and Parkinson’s disease. But those findings don’t always translate to human biology. Human genetics offers a path to determining which genes among those networks are most relevant to human disease.

Researchers at Harvard Medical School have developed a new statistical framework to link networks identified in models with human genetic data. This could make it faster and easier for researchers to identify which groups of genes are most likely to contribute to a particular human disease, uncover rare disease-causing mutations and zero in on promising therapeutic targets.

The work was published in Cell Genomics.

Cryo-EM helps identify the mechanisms of dental plaque formation

Periodontal (gum) disease is one of the most prevalent diseases worldwide, caused by the bacterium Porphyromonas gingivalis (P. gingivalis). In Japan alone, approximately 80% of adults 30 and older are affected or considered at risk.

Published in Communications Biology, a joint study by the Okinawa Institute of Science and Technology (OIST), Tottori University, Hiroshima University and Nagasaki University provides new insights into how this bacterium causes plaque formation.

Using cryo-electron microscopy (cryo-EM), the researchers reveal the 3D structure of Mfa pili, an arm-like filament that enables the bacteria to stick to host tissues and other microbes.

Faster breast MRI—AI unlocks one image per second and sharper tumor tracking

A group of researchers from the Technion and the United States reports a breakthrough in MRI scanning in a paper published in Nature Communications. The researchers developed an innovative method that accelerates and enhances MRI scans for breast cancer imaging, a disease diagnosed in approximately 2.3 million people each year, most of whom are women.

The new method, called ELITE, combines artificial intelligence with advanced mathematical models, enabling dynamic MRI with unprecedented speed and accuracy. This international study brings together expertise in engineering, MRI physics, artificial intelligence and clinical radiology.

Dr. Eddy Solomon of the Technion’s Faculty of Biomedical Engineering, the paper’s lead author, explains that the study focuses on dynamic MRI, a critical technology in breast cancer diagnosis. Dynamic MRI is used primarily for screening populations at high risk for breast cancer and is characterized by exceptionally high sensitivity, with more than 90% accuracy, compared with approximately 50%–60% for ultrasound and mammography combined. However, MRI technology faces a major challenge: Producing highly detailed images usually requires longer scan times, making it difficult to track the flow of contrast material through the examined tissue.

Rare aging disorder links ‘biological clock’ to disease

Scientists have discovered a rare genetic condition that causes people to age at a much faster rate, offering fresh insights into the aging process. The study shows for the first time how a “biological clock” present in every cell of the body could contribute to age-related diseases.

Experts say the findings could support the design of future medicines to counter diseases linked to older age, as life expectancies continue to rise across the globe.

The study is published in the journal Nature Genetics.

Orbital files plans for 100,000 orbital data centers

TAMPA, Fla. — Five-month-old startup Orbital has asked the Federal Communications Commission for permission to deploy up to 100,000 data center satellites, aiming to bring 10 gigawatts of computing power from space to meet rising artificial intelligence demand.

The filings submitted June 24 add a few more details for a constellation the Los Angeles-based venture first outlined earlier this month, when it emerged from stealth with $5 million in pre-seed funding ahead of a demonstration mission next year.

They include plans to deploy 100-kilowatt-class satellites in low Earth orbit at altitudes of 500–850 kilometers, with solar arrays and radiators spanning around 100 meters and a dry mass of 1.5−2.5 metric tons.

“Breakthrough” robot with lab-grown “human brain” promises advancement in brain-computer interfacing

Chinese researchers from Tianjin University and the Southern University of Science and Technology have created a groundbreaking robot powered by a tiny organoid derived from human stem cells grafted to a neural interface. This breakthrough system allows the robot to learn tasks like obstacle avoidance and object manipulation.

Described as the “world’s first open-source brain-on-chip intelligent complex information interaction system,” the technology marks a significant advancement in brain-computer interfaces (BCIs) – devices that translate between neural and computational signals.

The South China Morning Post notes that the scientists grew the organoids from human pluripotent stem cells, which can develop into various cell types, including neural tissue. These synthetic-organic (pardon the oxymoron) brain cells are linked to the robot’s neural interface, enabling communication between the neural tissue and the robot’s systems. Although the presented images of pink brain matter are merely mockups (below), the actual organoids are much smaller.

Could We Reach Alpha Centauri in 20 Years?

Alpha Centauri is 4.37 light years away—so could we reach it in 20 years? Only by leaving ordinary rockets behind for beamed sails, antimatter, or stranger drives. 🚀 Join this channel to get access to perks: https://www.youtube.com/channel/UCZFipeZtQM5CKUjx6grh54g/join 🛒 SFIA Merchandise: https://isaac-arthur-shop.fourthwall.com/ 🌐 Visit our Website: http://www.isaacarthur.net ❤️ Support us on Patreon: https://www.patreon.com/IsaacArthur ⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-arthur 👥 Facebook Group: https://www.facebook.com/groups/1583992725237264/ 📣 Reddit Community: https://www.reddit.com/r/IsaacArthur/ 🐦 Follow on Twitter / X: https://twitter.com/Isaac_A_Arthur 💬 SFIA Discord Server: https://discord.gg/53GAShE

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