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Human heart regrows muscle cells after heart attack, world-first study shows
This study provides the first direct evidence of cardiomyocyte mitosis in the adult human heart following myocardial infarction, challenging the long-standing paradigm that cardiac muscle cells are incapable of regeneration. Utilizing live human heart tissue models, researchers from the University of Sydney demonstrated that while fibrotic scarring occurs post-ischemia, the heart simultaneously initiates a natural regenerative program characterized by active cell division. The investigation further identified specific regulatory proteins that drive this mitotic process, offering a molecular blueprint for endogenous tissue repair. These findings suggest that the human heart possesses a latent regenerative capacity that could be therapeutically harnessed to prevent heart failure and reverse post-infarct tissue damage, representing a significant shift in regenerative cardiovascular medicine.
A world‑first University of Sydney study reveals that the human heart can regrow muscle cells after a heart attack, paving the way for breakthrough regenerative therapies to reverse heart failure.
New quantum boundary discovered: Spin size determines how the Kondo effect behaves
Collective behavior is an unusual phenomenon in condensed-matter physics. When quantum spins interact together as a system, they produce unique effects not seen in individual particles. Understanding how quantum spins interact to produce this behavior is central to modern condensed-matter physics.
Among these phenomena, the Kondo effect—the interaction between localized spins and conduction electrons—plays a central role in many quantum phenomena.
Yet in real materials, the presence of additional charges and orbital degrees of freedom make it difficult to isolate the essential quantum mechanism behind the Kondo effect. In these materials, electrons don’t just have spin, they also move around and can occupy different orbitals. When all these extra behaviors mix together, it becomes hard to focus only on the spin interactions responsible for the Kondo effect.
Proton Beam vs Intensity-Modulated Radiotherapy in Olfactory Neuroblastoma
In patients with advanced olfactory neuroblastoma, IMRT and PBRT yielded similar long-term outcomes and rates of grade 2 or higher radiation-related adverse events. Theoretical benefits of PBRT—such as organ sparing—require further study to clarify potential clinical advantages.
Question Does adjuvant proton beam radiotherapy (PBRT) provide equivalent oncologic effectiveness while reducing radiation toxic effects compared with adjuvant intensity-modulated radiotherapy (IMRT) for patients with olfactory neuroblastoma (ONB)?
Findings In this propensity score–matched cohort study of 54 patients, patients treated with adjuvant IMRT and PBRT had similar rates of radiation toxic effects and no statistical difference in overall survival and recurrence-free survival.
Meaning PBRT may not improve overall survival, recurrence-free survival, or radiation toxic effects relative to IMRT for patients with ONB.
Entangling gates on degenerate spin qubits dressed by a global field
Global control of a qubits using a single microwave field is a promising strategy for scalable quantum computing. Here the authors demonstrate individual addressability vial local electrodes and two-qubit gates in an array of Si quantum dot spin qubits dressed by a global microwave field and driven on-resonance.
