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NASA navigation experiment shows promise for planetary landings

NASA has successfully demonstrated technology designed to help spacecraft autonomously navigate to safe landing sites on the moon and on other planets. An Alta-X drone equipped with the agency’s Safe and Precise Landing—Integrated Capabilities Evolution (SPLICE) guidance, navigation and control payload completed simulated lunar descent and landing maneuvers Aug. 27. The flight took place at Rogers Dry Lake near NASA’s Armstrong Flight Research Center in Edwards, California.

During the tests, the SPLICE payload used an advanced guidance system to map the terrain and assess potential landing areas. If the system determines the targeted landing area is unsafe, the system diverts the drone to a safer location. The system generates high-resolution digital elevation maps from light-detection and sensor data.

Researchers at NASA’s Johnson Space Center in Houston developed the SPLICE payload and partnered with specialists at NASA Armstrong to integrate, test and fly it aboard the Alta-X drone in June and July. Those tests verified communications, data handling, telemetry and command-and-control performance between the SPLICE payload and the drone to prepare for a full-scale test at Voyager Technologies in Mojave, California, later this month.

New method detects lung antibodies through non-invasive exhaled breath

For the first time, researchers have succesfully measured antibodies against specific respiratory viruses in exhaled air. This is shown in a new study involving, amongst others, the Karolinska Institutet, published in eBioMedicine. The method may make it easier to study the immune system in the small airways of the lungs.

Antibodies in the mucosal lining of the respiratory tract play an important role in protecting against respiratory viruses such as influenza virus, SARS-CoV-2 and respiratory syncytial virus (RSV). While antibodies in the upper airways are relatively easy to measure, sampling from the lower airways has previously required invasive procedures such as bronchoscopy.

In the new study, researchers used a non-invasive method called PExA (Particles in Exhaled Air). By breathing into a specially designed instrument, participants generated tiny exhaled particles originating from the respiratory tract lining fluid of the small airways. These particles were collected and analysed for virus-specific antibodies.

Cytokine Signaling in Tumor Progression

Cytokines are molecules that play critical roles in the regulation of a wide range of normal functions leading to cellular proliferation, differentiation and survival, as well as in specialized cellular functions enabling host resistance to pathogens. Cytokines released in response to infection, inflammation or immunity can also inhibit cancer development and progression. The predominant intracellular signaling pathway triggered by cytokines is the JAK-signal transducer and activator of transcription (STAT) pathway. Knockout mice and clinical human studies have provided evidence that JAK-STAT proteins regulate the immune system, and maintain immune tolerance and tumor surveillance. Moreover, aberrant activation of the JAK-STAT pathways plays an undeniable pathogenic role in several types of human cancers.

Cancer-linked gene uses ‘shortcut’ to trigger cell division

Living cells are one of the few materials that can replicate themselves, and this is crucial for tissue development and recovery from injury or illness. But making sure cell division only happens at the right time is essential; otherwise, unregulated replication can lead to problems like cancer.

Researchers at the University of California, Santa Cruz, are studying how cells know when and how to divide, and how genes known to be important in cancer influence these processes.

A new study published in The EMBO Journal finds that a gene affected in many cancers, known as E2F1, can cause cells to divide without having to abide by the normal rules of cell division. Instead of having to unpack the genetic material inside the cell, E2F1 takes a shortcut by binding directly to a small area of the DNA that remains tightly packaged inside the cell.