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Blood metabolite signature offers improved prediction of type 2 diabetes risk

Diabetes, a metabolic disease, is on the rise worldwide, and over 90% of cases are type 2 diabetes, where the body does not effectively respond to insulin.

Researchers from Mass General Brigham and Albert Einstein College of Medicine have identified metabolites (small molecules found in blood generated through metabolism) associated with the risk of developing type 2 diabetes in the future, and have revealed genetic and lifestyle factors that may influence these metabolites. They also developed a metabolomic signature that predicts future risk of type 2 diabetes beyond traditional risk factors.

Their results are published in Nature Medicine.

Combating Antimicrobial Resistance by Resensitising Bacteria to Antibiotics Using CRISPR: A Narrative Review

Background: Antimicrobial resistance (AMR) remains a formidable global health threat. Conventional strategy of developing new antibiotics is costly and unsustainable. Thus, innovative approaches for resensitising bacteria using clustered regularly inter-spaced short palindromic repeats (CRISPR) technology are sought.

Scientists create food powder from waste, increasing shelf life from two weeks to two years

Food waste could actually feed millions of people globally and also have an endless shelf life if we freeze dry it and turn it into powder. This way we can keep large quantities of food for a very long time rather than having to freeze it or pickle it which only last so long due to freezer burn and pickling doesn’t work for long periods of time which can turn to poison essentially if contaminated.

Three students from Lund University in Sweden have set up a business called Fopo (freeze dried food powder) buying expired fruit and vegetables and turning it into food powder to resell back into the F&B market.

One way brain ‘conductors’ find precise connection to target cells

New research reveals how a class of neurons that help coordinate communication in the brain link up with their target cells, identifying two molecules that must be present before synapses, the structures that carry signals between these partners, can form on the target neurons.

These cells are inhibitory interneurons that connect to a specific location on target excitatory neurons, regulating information processing and maintaining proper balance in brain circuits by controlling how active the excitatory neurons become. Loss of coordination between these two types of cells, which leads to circuit malfunction, is associated with such disorders as epilepsy, depression, autism and schizophrenia.

CT Perfusion Abnormality in Hypoglycemic Focal Neurological Deficits

Stroke Image highlights the interplay between hypoglycemia and perfusion abnormalities in a person with acute focal neurological deficits.

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Advancing Early Detection of Alzheimer Disease in the Primary Care Setting in the United States

Background and ObjectivesAs evidence supporting the robustness of blood-based biomarker (BBM) testing for Alzheimer disease (AD) continues to emerge, understanding the perceptions, drivers, and barriers to the adoption of these tests among primary care…

Use of Ictal-Interictal SPECT in Localization of Surface-EEG–Negative Insular Epilepsy

This case demonstrates the use of ictal SPECT as an objective way to localize surface-EEG–negative insular seizures.

A 43-year-old woman presented with events characterized by a “funny” feeling in the head, nausea, and right-hand numbness/cramping. Events lasted minutes, without impaired awareness. Onset occurred 1.5 years after an embolic left middle cerebral artery stroke. MRI showed left temporoparietal and insular T2 changes.

Synchrotron‐generated microbeams as a radiosurgical alternative for drug‐resistant epilepsies: Proof of concept in a mouse model of mesiotemporal lobe epilepsy

“This proof-of-concept study highlights MRT as a promising non-invasive therapy for drug-resistant focal epilepsies with optimal peak doses of 125–250 Gy, and it suggests that distributing the dose through multiple angles optimizes the therapeutic effect. MRT could provide a safer alternative to surgery, warranting further investigations.”

Read this open-access research article from Epilepsia Journal at doi.org/10.1002/epi.70063.

Objective One-third of patients with epilepsy, particularly those with mesial temporal lobe epilepsy (MTLE), remain resistant to medication. Resective surgery, the gold standard, is highly invasive and carries significant risks. Here, using a mouse model, we explored the potential of microbeam radiation therapy (MRT), a new technique based on the spatial microfractionation of high-flux X-rays, as a non-invasive alternative for treating MTLE.

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