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Do ICIs Have Long-Term Survival Benefit?

A cross‑sectional analysis found that few registration trials assessing immune checkpoint inhibitors (ICIs) cancer therapies report long-term overall survival data. Among nearly 90 FDA-approved ICIs indications in the metastatic setting, less than one third of trials had overall survival data at 3 years, and even fewer (about 11%) reported overall survival data at 5 years.

Most registration trials for ICI cancer therapies don’t report long term overall survival data, a cross-sectional analysis finds.

Abstract: Introducing a new player in GLP-1-regulated insulin secretion…

Jeffrey R. Schelling & team find inhibition of the fatty acid transport protein FATP2 exerts glucose-lowering effects through GLP-1 secretion by alpha cells:

The figure shows FATP2 expression localizes to pancreatic alpha cells in mouse islets.

1Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

2Louis Stokes Cleveland VA Medical Center, VA Northeast Ohio Healthcare System; Department of Ophthalmic Research, Cole Eye Institute, Cleveland, Ohio, USA.

3Department of Medicine and Naomi Berrie Diabetes Center, Vagelos College of Physicians and Surgeons of Columbia University, New York, New York, USA.

Expanding the search for quantum-ready 2D materials

Quantum technologies from ultrasensitive sensors to next-generation information processors depend on the ability of quantum bits, or qubits, to maintain their delicate quantum states for a sufficiently long time to be useful.

One of the most important measures of this stability is the spin coherence time. Unfortunately, qubits may lose coherence because their environment is “noisy,” for example, due to the presence of nuclear isotopes or other interference that disturbs the qubit.

Two-dimensional (2D) materials—or atomically thin sheets—can offer quiet environments for qubits, as their reduced thickness naturally lowers the number of isotopes that interact with the qubit.

New Paper-Thin Brain Implant Could Transform How Humans Connect With AI

A radically miniaturized brain implant called BISC is redefining what’s possible in human–computer interaction, offering a paper-thin, wireless, high-bandwidth link directly to the brain.

With over 65,000 electrodes and unprecedented data throughput, it enables advanced AI decoding of thoughts, intentions, and sensory experiences while remaining minimally invasive.

Researchers Use Virus To Trace Psilocybin’s Effects Across the Entire Brain

An international collaboration led by Cornell researchers used a combination of psilocybin and the rabies virus to map how – and where – the psychedelic compound rewires the connections in the brain.

Specifically, they showed psilocybin weakens the cortico-cortical feedback loops that can lock people into negative thinking. Psilocybin also strengthens pathways to subcortical regions that turn sensory perceptions into action, essentially enhancing sensory-motor responses.

The findings published Dec. 5 in Cell. The lead author is postdoctoral researcher Quan Jiang.

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