GLP-1 weight-loss drugs alter brain circuits in the amygdala and dopamine system to reduce the motivation to seek out high-calorie foods.
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In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid NanoparticlesClick to copy article linkArticle link copied!
A nicely concise paper on antibody-linked lipid nanoparticles which target hematopoietic stem and progenitor cells in vivo, important yet tricky cell types to transduce for hematological gene therapy.
Ex vivo autologous hematopoietic stem cell (HSC) gene therapy has provided new therapies for the treatment of hematological disorders. However, these therapies have several limitations owing to the manufacturing complexities and toxicity resulting from required conditioning regimens. Here, we developed a c-kit (CD117) antibody-targeted lipid nanoparticle (LNP) that, following a single intravenous injection, can deliver RNA (both siRNA and mRNA) to HSCs in vivo in rodents. This targeted delivery system does not require stem cell harvest, culture, or mobilization of HSCs to facilitate delivery. We also show that delivery of Cre recombinase mRNA at a dose of 1 mg kg–1 can facilitate gene editing to almost all (∼90%) hematopoietic stem and progenitor cells (HSPCs) in vivo, and edited cells retain their stemness and functionality to generate high levels of edited mature immune cells.
Yann Le Cun : « Ce que nous construisons, c’est ni plus ni moins que le cortex préfontal des machines »
ENTRETIEN. Pour le chercheur, Prix Turing 2018, la prochaine révolution robotique – celle de systèmes vraiment autonomes et dotés d’une véritable compréhension du réel – n’est possible que si l’on ancre l’IA dans le monde physique.
What Higher Dimensional Beings Look Like (And They’re Watching!) Per Donald Hoffman
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Chapters:
Anthropic research warns AI could build itself by 2028
In this exclusive interview, Axios co-founder Mike Allen sits down with Anthropic co-founder Jack Clark to discuss his warning that by 2028, AI systems may be able to improve and build better versions of themselves.
Clark explains why Anthropic is preparing for the possibility of an “intelligence explosion,” how advanced AI could accelerate breakthroughs in science and medicine, and why governments, companies and researchers need new plans for cyber threats, bio risks, economic disruption and the future of work.
Timestamps:
00:00 — Introduction: the future of AI
00:41 — The 2028 prediction: AI building itself.
01:49 — The risks of rapid acceleration.
03:11 — The 3D printer metaphor.
05:21 — Intelligence explosion and fire drill scenarios.
06:55 — Building a \.
Engineered wood provides solar power even after the sun goes down
While sustainable solar energy can potentially meet our global power needs, it has one major flaw. When sunlight disappears, solar panels stop generating electricity. The problem is that while they do an excellent job of converting light into power, they are not so good at storing the energy they collect.
One solution is to use materials known to capture heat and release it later, such as phase change materials (PCMs). However, these can leak when they melt, struggle to conduct heat quickly, and catch fire easily. So researchers from China decided on a different approach, turning wood into a multifunctional solar-thermal energy storage material, as they detail in a paper published in Advanced Energy Materials.
Reengineering balsa wood The team redesigned the internal structure of balsa wood at multiple scales, from nano to micro, to create a material that absorbs sunlight and stores it as heat for later use. It can also generate electricity when that stored heat is released through a thermoelectric device.
Novel diabetic wound treatment turns cells into manufacturers
Spread the love Diabetes affects more than 40 million people in the United States, according to the American Diabetes Association. For many, the chronic condition means a lifetime of pain as worsening circulation leads to nonhealing ulcers in the extremities, especially the legs and feet. Chronic inflammation, difficulty in forming nutrient-carrying capillaries, and overzealous immune cells…
The Ant and the Absolute: How Feynman Discovered Bio-Computing in a Sink
Why does an ant, with a brain smaller than a grain of sand, find the shortest path better than a human engineer?
Richard Feynman didn’t learn about ants from a textbook. He learned by sitting on his bathroom floor with a sugar cube and a stopwatch. What he discovered wasn’t just biology—it was a biological supercomputer solving the \.
New MRI technology maps 20-plus brain biomarkers in a single 14-minute scan
New multiplexed imaging technology using standard clinical MRI systems can simultaneously map more than 20 biomarkers in high resolution, providing a comprehensive view of the brain with a single scan.
Researchers at the University of Illinois Urbana-Champaign demonstrated the multiplexed MRI technology (MRx) by characterizing brain tumors and multiple sclerosis lesions—revealing different structural, physiological and molecular changes within the diseases. Led by Zhi-Pei Liang, a professor of electrical and computer engineering and a member of the Beckman Institute for Advanced Science and Technology at the U. of I., the team has reported its findings in the journal Nature.
“MRx can be a powerful tool for noninvasive tissue characterization, helping to advance personalized, precision and predictive medicine,” Liang said. “By providing rich, multidimensional biomarkers to capture disease progression and treatment response, this capability could open new opportunities for more precise diagnosis, individualized treatment planning and improved patient outcomes.”