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Human T-cell receptor–CD3 complex structure unraveled!

Mean motor disconnectivity (MMD), evaluated on MRI imaging, explains additional variability in skilled hand function after subacute stroke, beyond motor evoked potential status and corticospinal tract lesion load.

BACKGROUND: Persistent compromised hand function is one of the most common long-term deficits after stroke. It is related to dysfunction of the primary motor cortex (M1) and corticospinal tract (CST) as assessed by magnetic resonance imaging-derived estimates of CST lesion load or by transcranial magnetic stimulation-derived measures, such as motor evoked potential (MEP) status. However, substantial interindividual variability remains with these measures. We tested whether a novel measure, mean motor disconnectivity (MMD), explains additional variation in the hand function of subacute stroke patients. METHODS: Thirty-two participants (15 M/17 F; age, 58.6±9.65 years) after unilateral ischemic stroke involving the CST and related upper extremity weakness were studied within 4 weeks of stroke in a cross-sectional study design at Emory University between 2015 and 2021.

RIKEN-led Project Seeks to Combine The Powers of Quantum Computers And Supercomputers

While supercomputers excel at general-purpose tasks and large-scale simulations, quantum computers specialize in problems involving exponential combinations (e.g., materials science, drug discovery, AI optimization). However, quantum systems currently require conventional computers to operate—a dependency that will intensify as they scale from today’s 100+ qubits to thousands or millions. The project envisions supercomputers acting as the “pianists” that play the quantum “piano.”

Twelve user groups are currently testing both systems. The project’s primary objective is to provide concrete answers to “What can quantum computers do *now*?” rather than speculating about future capabilities, while demonstrating practical advantages of tightly integrated hybrid computing for real-world scientific and industrial applications.

A RIKEN-led project is developing system software to tightly integrate quantum computers with supercomputers.

Iatrogenic Cerebral Amyloid Angiopathy–Related InflammationA Multicenter Case Series

Variants of cerebral amyloid angiopathy (CAA) have been increasingly reported. This study reports on a case series of patients with iatrogenic CAA who developed clinical and radiologic features of CAA-related inflammation.

Background and Objectives.

Prenatal caffeine exposure induces autism-like behaviors in offspring under a high-fat diet via the gut microbiota-IL-17A-brain axis

This recently published research is compelling. “Microbiota-IL-17A-brain axis… induced ASD” both in and out of the womb has been our focus in learning about injury. ‘’ https://www.sciencedirect.com/science/article/pii/S0147651323013015 Interesting to see differences related to sex given much higher ASD rates in males, though that ratio has changed over the years.

You may be able to guess what kinds of things can affect microbiota-IL-17A-brain axis in infants, leading to neutrophil activity and brain inflammation in context of gut dysbiosis, a microbial predisposition to adverse reaction and injury. No research is published on this dynamic. Zero. microbiomevaccinesafetyproject Note: this is also the pathway explaining fever reducing symptoms in autism, a double-edged sword. https://www.facebook.com/share/p/1C3ZjUoV8k/

Prenatal caffeine exposure (PCE) is a significant contributor to intrauterine growth retardation (IUGR) in offspring, which has been linked to an increased susceptibility to autism spectrum disorder (ASD) later in life. Additionally, a high-fat diet (HFD) has been shown to exacerbate ASD-like behaviors, but the underlying mechanisms remain unclear. In this study, we first noted in the rat model of IUGR induced by PCE that male PCE offspring exhibited typical ASD-like behaviors post-birth, in contrast to their female counterparts. The female PCE offspring demonstrated only reduced abilities in free exploration and spatial memory. Importantly, both male and female PCE offspring displayed ASD-like behaviors when exposed to HFD.

Algorithm matches drugs to glioblastoma’s diverse cell types, offering hope for individualized therapies

Researchers have developed a new computational approach that uncovers possible drugs for specific cellular targets for treating glioblastoma, a lethal brain tumor. This approach enabled them to predict more effective treatment combinations to fight the disease on an individualized basis.

This laboratory and computational research effort was led by scientists at Georgetown’s Lombardi Comprehensive Cancer Center.

“The cellular targets we identified could be key to effectively fighting a disease that has seen only one new targeted drug approved in the last two decades,” says Nagi G. Ayad, Ph.D., senior author, associate director for translational research, and professor of oncology at Georgetown Lombardi.

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