JWST has created a map of dark matter that is twice as good as anything we have had before, and it may help unravel some of the deepest mysteries of the universe
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Recently, variable length dystrophin constructs have been characterized in models of Duchenne muscular dystrophy (DMD)
Here, Hichem Tasfaout & team describe a new method for using proteomics to evaluate the efficacy of three dystrophin-replacement approaches using AAV vectors.
1Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota — Twin Cities, Minneapolis, Minnesota, USA.
2Department of Neurology.
3Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, and.
4Department of Biochemistry, University of Washington School of Medicine, Seattle, Washington, USA.
Atorvastatin and Aortic Stiffness During Anthracycline-Based Chemotherapy
Statin therapy before and during anthracycline-based chemotherapy resulted in fewer cases of elevated pulse wave velocity and reduced aortic distensibility compared with placebo. The results suggest a potential protective effect of atorvastatin against vascular dysfunction in cancer survivors.
Question Does 12 months of treatment with atorvastatin mitigate anthracycline-associated increased aortic stiffness, an important factor associated with adverse cardiovascular outcomes?
Findings In this secondary analysis of 300 participants with lymphoma enrolled in the STOP-CA (Statins to Prevent the Cardiotoxicity From Anthracyclines) randomized clinical trial, atorvastatin was associated with significantly lower odds of an increase (≥0.8 m per second) in magnetic resonance imaging–derived aortic arch pulse wave velocity, compared with placebo. The proportion of participants meeting this primary exploratory end point was significantly lower with atorvastatin (5%), compared with placebo (50%).
Meaning These findings suggest that pretreatment with atorvastatin is associated with preserved vascular function in patients undergoing anthracycline treatment.
Scientists Identify Brain Waves That Define The Limits of ‘You’
At what point do “you” end and the outside world begins?
It might feel like a weird question with an obvious answer, but your brain has to work surprisingly hard to judge that boundary. Now, scientists have linked a specific set of brain waves in a certain part of the brain to a sense of body ownership.
In a series of new experiments, researchers from Sweden and France put 106 participants through what’s called the rubber hand illusion, monitoring and stimulating their brain activity to see what effect it had.
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
Now online! (Cell 186786–802.e1–e15; February 16, 2023)
Now online! (Cell 186, 786–802.e1–e15; February 16, 2023)
In our original published article, we performed western blots and imaging of induced motor neurons (iMNs) to elucidate the mechanism through which PIKFYVE inhibition causes secretion and clearance of aggregation-prone proteins such as phosphorylated TDP-43 (pTDP-43). Since publication, we have become aware of 3 errors in figure legends or images that we are now correcting.
What Are the Roles of Mitochondrial Stress Responses and Mitohormesis in Neurodegenerative Disorders?
Structure basis for the activation of KCNQ2 by endogenous and exogenous ligands.
Zhao et al. report cryo-EM structures of human KCNQ2 in complex with QO-58 and QO-83 in multiple conformations, with or without PIP2. Together with electrophysiological and computational analyses, these structures provide insight into the channel’s activation mechanism and support the rational design of targeted anti-epileptic therapies.
Rim Lesions and Development of MS in Radiologically Isolated Syndrome
In #RadiologicallyIsolatedSyndrome, greater paramagnetic rim lesion burden on MRI was associated with increased risk and earlier development of clinical MultipleSclerosis.
Question Are paramagnetic rim lesions (PRLs) and central vein sign–positive white matter lesions (CVS+L) associated with developing clinical symptoms of multiple sclerosis (MS) in people with radiologically isolated syndrome (RIS)?
Findings In this cohort of 36 people with RIS, a higher PRL count was associated with a shorter time to developing clinical symptoms of MS and was an independent predictor of symptom onset; these findings were validated in an independent cohort of 43 people with RIS.
Meaning Results show that PRLs may have prognostic utility for risk stratification and help guide treatment decisions in people with RIS, the earliest detectable stage of MS.