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Tiny memristor chip cuts brain modeling time to under 10 milliseconds

A research team has developed the world’s first chip that can match the speed at which the human brain functions. The study, titled “A sub–10-millisecond neural dynamical system based on phase-change memristors,” was published in Science and was led by Professor Yang Yuchao of Peking University, together with researchers from the Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences.

Neural dynamical systems combine neural networks with mathematical equations that describe how complex systems change over time. They are useful for physical modeling, medical imaging and three-dimensional brain reconstruction. However, these systems require repeated calculations, error checks and adjustments to the size of each calculation step. In conventional computers, data must also move frequently between memory and the processor, increasing processing time and energy use.

Fast and accurate brain modeling is important for technologies that must respond in real time, including brain–computer interfaces, surgical navigation and medical imaging. Existing hardware often requires too much time and power for these demanding calculations. By performing key operations directly in memory, the new chip reduces data movement and brings high-quality brain modeling closer to real-time use.

Apatinib Causes Hypertension via Drp1Mediated Endothelial Mitochondrial Fission

BACKGROUND: Apatinib is a tyrosine kinase inhibitor used for targeted cancer therapy, but its cardiovascular toxicity, particularly hypertension, limits its clinical application. We observed significant mitochondrial fragmentation in endothelial cells after apatinib treatment. This study aims to investigate the role of endothelial mitochondrial fission mediated by Drp1 (dynamin-related protein 1) in apatinib-induced hypertension. METHODS: We established an apatinib-targeted gastric cancer–bearing nude mice model. Apatinib was also administered to human umbilical vein endothelial cells in vitro. Mitochondrial morphology changes in endothelial cells were examined. The role of Drp1 in this process was validated using various experimental methods.

A spatial in situ hybridization approach to T cell clonotype analysis using T cell receptor variable gene probes

Ly et al. developed a spatial in situ hybridization approach using TCR variable-gene probes to map T cell clonality and phenotype at single-cell resolution. By applying this technique to autoimmune kidney biopsies, they found that expanded T cells form localized clusters near antigen-presenting cells, consistent with local activation and proliferation.

Gut microbial metabolites may shape vulnerability to stress-related mental disorders

Gut microbiome-derived metabolites may influence stress-related mental disorders through neural, immune, endocrine, and epigenetic pathways. Evidence is strongest for depression and preclinical models, while larger longitudinal human studies are needed to establish causality and clinical value.

Scientists Broke a 160-Year-Old Law of Physics to Create Programmable Heat

There are certain laws of physics that heat must follow.

Take Kirchhoff’s law of thermal radiation, for example, which applies the idea of reciprocity to heat, and dictates that a surface’s ability to absorb heat at a specific angle and wavelength must also match its ability to emit heat at the same angle and wavelength.

It’s a rule that makes thermal energy difficult to control in ways we might like to, and although workarounds have been found before, they’re inefficient and volatile.

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