“Vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via microbial N-bc2S1P synthesis on neonatal skin” http://spkl.io/6184A4yYI
CellHostandMicrobe.
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Researchers have uncovered a pathway that keeps bone resorption in check by dampening the activation of inflammasomes in osteoclasts—identifying an important restraint and helping to answer a paradox in the field of bone biology.
Learn more in Science Signaling.
The ER protein Tmem178 prevents bone loss by limiting Ca2+-dependent inflammasome activation in osteoclasts.
Online now: DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function: (Cell Metabolism 38, 1–18.e1–e7; April 7, 2026)
Online now: (Cell Metabolism 38, 1–18.e1–e7; April 7, 2026)
After manuscript revision, the International Indirect Calorimetry Consensus Committee (IICCC) established new guidelines for analysis of indirect calorimetry (10.1038/s42255-025–01360-4), emphasizing the use of metabolic rates and ANCOVA not normalized to body weight. In response, the authors have expanded the description of the indirect calorimetry data analysis and replaced the lean-mass-normalized VO2 graphs with non-normalized energy expenditure graphs with ANCOVA. With a few other minor edits, these changes provide further context for the analytical framework and consistent interpretation.
Now, MIT scientists have released an AI called DefensePredictor that can root out new bacterial defense systems in five minutes, instead of weeks or months. As proof of concept, DefensePredictor churned through hundreds of thousands of proteins in multiple strains of Escherichia coli (E. coli). Over 600 proteins not previously linked to immune defense popped up. Added to a vulnerable strain of bacteria, a subset of these protected them against attack.
“E. coli harbors a much broader landscape of antiphage defense than previously realized, expanding the likely number of systems by multiple orders of magnitude,” wrote the team.
These systems might hold secrets about how immunity evolved. And because the proteins may work in different ways, they could be a goldmine for next-generation precision molecular tools.
