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Scientists turn protein-making errors in cancer cells into a targeted kill switch

Like every other cell in the human body, cancer cells also produce their own share of proteins for survival. During this production process, cells often encounter a glitch called ribosomal frameshifting. This exceptionally rare event occurs roughly once in every 100,000 translation events, when the ribosome, while reading genetic instructions to make a protein, shifts its reading position. A recent Nature study investigated whether this protein-building glitch in cancer cells can be turned into a targeted cancer therapy.

Ribosomes read mRNA in groups of three genetic letters, known as codons. To find out where this reading process goes wrong, the researchers developed high-throughput dual-luciferase reporter libraries containing randomized genetic sequences. This allowed them to systematically track instances where ribosomes slipped out of their usual reading frame.

The ribosome profiler pinpointed specific codon pairs, such as AGAACG, that frequently trigger ribosomes to slip backward by one letter (a −1 frameshift) in cancer cells. Noncancerous cells, however, read these sequences normally.

Upgraded microscope can now watch individual quantum particles in motion

Energy can be carried in a number of ways: by electrons, the particles that underpin all modern electronics, as well as by quasiparticles, the results of different particles interacting with one another at the quantum level. Columbia chemist Milan Delor has been watching these different forms of energy flow with an instrument called stroboSCAT, a unique microscope that uses strobe-like light pulses to capture particles and quasiparticles as they move through different materials.

The latest iteration of stroboSCAT, described in Nature Materials, can now resolve individual quantum energy carriers as they move through materials for the first time. It can also observe their interactions with greater precision than existing imaging techniques.

Electrons can easily be tracked using transport measurements that record electrical resistance. But such techniques cannot directly capture quasiparticles, like charge-neutral excitons or spin excitations. Delor first developed stroboSCAT as a postdoc working with Naomi Ginsberg at the University of California, Berkeley, in 2019. Over the years, he and his lab at Columbia have increased its temporal resolution to femtoseconds and its spatial resolution to just a few nanometers, and deployed it to detect electrons, excitons, phonons, magnons, ferrons, photons, polaritons and polarons in a variety of semiconductors and metals.

Your brain may map emotional concepts onto a hexagonal grid, new study suggests

Everyday life throws a whole range of emotional experiences our way, from exciting and relaxing moments to tense or gloomy encounters. Each experience is shaped by what’s present around us in the moment, the sensations our body is experiencing and our past experiences. This entire scene is set by the brain, which draws on these experiences of the past, organizing the information it gathers into mental maps that help us predict what might happen and respond appropriately to different situations.

In a recent study published in PLOS Biology, researchers investigated whether the human brain maps emotions using a coordinate system. They designed emotion-tracking experiments and behavioral tests in which participants watched changing facial expressions or read pairs of emotionally meaningful phrases, then judged changes in pleasantness or arousal. During these tests, researchers peeked into their brain activity using high-resolution functional MRI (fMRI).

The scans revealed a distinct sixfold (hexadirectional) symmetry in the ventromedial prefrontal cortex (vmPFC)—the brain’s emotion regulation, decision-making and self-control center—as participants tracked changes in emotion. The neural activity followed a geometric pattern, with brain patterns showing greater similarity when emotional paths aligned with the same 60° grid angles than when they did not.

An inside look at a molecular switch that triggers inflammation

Researchers at VIB and Ghent University have uncovered how an important driver of inflammation is activated at the molecular level. Their findings, published in Science Immunology, also explain how a medicine used to treat a severe form of psoriasis blocks this inflammatory signal.

Inflammation is an essential part of the body’s defense against infection and injury. But when inflammatory signals become too strong or poorly controlled, they can contribute to diseases such as psoriasis.

One important player is the IL-36 receptor, a protein that helps cells respond to inflammatory signals. Researchers led by Dr. Danielle Clancy and professor Savvas Savvides (VIB-UGent Center for Inflammation Research) have now revealed in unprecedented detail how this receptor is switched on.

First known ‘disappearing planet’ has a neighbor that makes it wobble like a top

UCLA-led astronomers have discovered the first known “disappearing planet” about 1,000 light-years away. The planet, TOI-2535 b, is a “hot Jupiter,” a gas giant that orbits extremely close to its host star. TOI-2535 b whips around its star in only 8.25 days—10 times faster than the 88 days that Mercury takes to go around our sun once.

Researchers observed TOI-2535 b transit its star multiple times over seven years, until they stopped seeing it altogether. But as they show in an article published in Astrophysical Journal Letters, the planet hasn’t truly vanished. Instead, gravity from a neighboring planet is tilting its orbit.

TOI-2535 b was identified in images taken by NASA’s Transiting Exoplanet Survey Satellite (TESS) space telescope of the TOI-2535 star system between April 2019 and March 2026. TESS discovers planets by measuring the small changes in a star’s brightness that occur when a planet passes in front of its star, blocking a bit of its light. These events, known as transits, require a precise alignment between the star, planet and our line of sight to be noticeable.

Strange Materials Make Waves Behave in Ways That Defy Expectations

Researchers have uncovered an unusual wave phenomenon that links engineered materials to principles found in ocean physics.

Waves bouncing around an irregularly shaped space typically follow increasingly unpredictable paths. Scientists have now shown that certain materials can produce the opposite effect, guiding waves into stable, repeating patterns instead of chaotic trajectories.

Researchers at the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) discovered this behavior in hyperbolic materials, whose unusual properties restrict the directions in which waves can travel. Their study, published in Nature Physics, identifies structures called “hyperbolic wave attractors” that could eventually help engineers control light, sound, and electromagnetic signals.

Is Einstein Wrong? Deep-Sea Neutrinos Put the Laws of Physics to the Test

Scientists are testing whether one of Einstein’s most fundamental principles holds true throughout the Universe.

A neutrino telescope deep in the Mediterranean Sea has put one of Einstein’s fundamental principles to a new test. After analyzing 5,828 atmospheric neutrino candidate events, scientists found no evidence that Lorentz invariance, a cornerstone of relativity, had been violated. Their findings place new restrictions on theories suggesting that the laws of physics might behave differently under certain conditions.

The international KM3NeT collaboration conducted the study using KM3NeT/ORCA, an underwater detector designed to investigate neutrinos and their unusual behavior. Published in the Journal of Cosmology and Astroparticle Physics (JCAP), the research establishes the first direct experimental limits on certain possible violations involving muon and tau neutrinos, two types of these elusive particles.

Hera’s first close-up view of Didymos asteroids

The European Space Agency’s Hera mission for planetary defence has acquired its first close-up of the Didymos binary asteroid system. NASA’s DART spacecraft impacted the smaller Dimorphos asteroid on 26 September 2022 – but this image gives a novel view of its adjacent parent asteroid.

In this image, acquired by Hera’s monochromatic Asteroid Framing Camera from 60 km away, most of the 151-m diameter Dimorphos asteroid is hidden by shadow but the 780-m diameter Didymos asteroid that the smaller moonlet orbits around is shown clearly.

“The first thing we said was wow!” observes Hera Principal Investigator Patrick Michel, Director of Research at CNRS / Observatoire de la Côte d’Azur. “This is the other side of Didymos from the one that DART’s camera showed us shortly before impact, so this feels like looking at a whole new world.

Manchester physicists step closer to the ‘Zeptoverse’ after 42-year particle search

Scientists have found the first evidence for an extremely rare particle decay known as ‘Bd to mu mu’.The decay is predicted to happen only once in around 10 billion beauty particles and has taken more than 40 years to find. The result has a statistical significance of 3.2 sigma, enough to constitute evidence, but not enough to claim the gold…