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Sep 27, 2023

The ARC nerve-stimulation system could help quadriplegic patients move their arms again

Posted by in categories: biotech/medical, neuroscience

How well that translation occurs remains to be seen while the patient learns and adapts to the new system. “The implant procedures involving the Onward ARC-IM and Clinatec BCI went smoothly,” Dr. Bloch said in an press release. “We are now working with the patient to use this cutting-edge innovation to recover movement of his arms, hands, and fingers. We look forward to sharing more information in due course.”

“If the therapy continues to show promise, it is possible it could reach patients by the end of the decade,” Onward CEO Dave Marver said in a statement to Engadget. “It is important to note that we do not expect people with spinal cord injury to wait that long for Onward to commercialize an impactful therapy — we hope to commercialize our external spinal cord stimulation solution, ARC-EX Therapy, to restore hand and arm function in the second half of 2024.”

Onward Medical among a quickly expanding field of BCI-based startups working to apply the fledgling technology to a variety of medical maladies. Those applications include loss of limb and self-regulatory function due to stroke, traumatic brain or spinal cord injury, physical rehabilitation from those same injuries, as well as a critical means of communication for people living with Locked-In Syndrome.

Sep 27, 2023

Risk for

Posted by in category: biotech/medical

Risk for community-onset C. difficile infection varies widely with choice of antibiotic.

The rising incidence of hospital-and community-acquired Clostridioides difficile infection (CDI) reinforces the need for more-effective prevention. Researchers performed a retrospective case-control study to examine relative risk for community-acquired CDI (CA-CDI) in patients receiving different oral antibiotics. Using administrative claims databases from 2001–2021 that included commercial, Medicare, and Medicaid records, they matched each CA-CDI case with five control patients for a total of 159,404 cases and 797,020 controls.

For cases occurring within 30 days of antibiotic exposure, the highest risk for CA-CDI occurred with clindamycin (adjusted odds ratio, 25.4) and the lowest with minocycline (AOR, 0.79; the only 1 of 27 oral antibiotics with an AOR 1.0). Other high-risk antibiotics were cefixime (AOR, 12.0), cefdinir (11.0), cefuroxime (9.6), cefpodoxime (9.2), amoxicillin-clavulanate (8.5), and ciprofloxacin (6.8). Older beta-lactams were lower risk (penicillin AOR, 1.8; amoxicillin, 2.0; cephalexin, 2.9; cefadroxil, 2.8). The lowest-risk antibiotic classes were the macrolides, sulfonamides, and tetracyclines. For all antibiotic classes, different agents had discernible differences in AOR for CA-CDI. A sensitivity analysis assessing relative risk for CA-CDI over multiple exposure periods up to 180 days found that the relative hierarchy of risk for the different antibiotics remained the same for each exposure period, and that overall risk progressively declined with time.

The authors acknowledge multiple limitations of their analysis, including use of administrative claims data to identify CA-CDI and outpatient claims data to identify antibiotic exposure and lack of information on inpatient antibiotic usage. Still, the large study population allowed for a more-precise definition of relative risk than in prior studies, not only showing a wide variation among beta-lactam antibiotics but also indicating that the risk associated with fluoroquinolone antibiotics falls between that of the older and newer cephalosporin classes.

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Sep 27, 2023

Scientists reveal half-billion-year-old ‘last supper’

Posted by in category: futurism

New analysis of trilobite fossil gives clues about ancient creature’s feeding behavior.

Sep 27, 2023

Dubai: Fully-automated self-driving taxis to hit the streets soon; Details here

Posted by in categories: robotics/AI, transportation

Dubai roads to have driverless taxis soon.

By Afreen Shaikh

Sep 27, 2023

Genetically modified bacteria break down plastics in saltwater

Posted by in categories: chemistry, engineering, genetics

A genetically engineered marine microorganism is shown to break down polyethylene terephthalate (PET) in saltwater. This plastic, used in everything from water bottles to clothing, is a significant contributor to microplastic pollution in oceans.

“This is exciting because we need to address plastic pollution in marine environments,” says Nathan Crook, corresponding author of a paper on the work and an assistant professor of chemical and biomolecular engineering at North Carolina State University.

Sep 27, 2023

Black Holes from Before The Universe Existed

Posted by in category: cosmology

An exploration of the idea Black Holes from Before The Universe Existed, and other black hole oddities.

My Patreon Page:

Continue reading “Black Holes from Before The Universe Existed” »

Sep 27, 2023

Architecture for Preventing Cognitive Decline: Contributions from Neuroscience to Healthy Aging

Posted by in categories: biotech/medical, life extension, neuroscience

Cognitive decline is a growing public health concern that affects millions of people around the world. Amid an aging population, strategies that help prevent or mitigate cognitive deterioration become increasingly relevant to support healthy aging and maintaining independence for longer. Studies in the field of neuroscience applied to architecture (neuroarchitecture) have shown that the physical environment, both internal and external, public and private, plays a fundamental role in this aspect [1]. In this sense, architects and urban planners can direct their projects to create solutions that significantly contribute to this objective.

The human brain is a very plastic organ. In other words, it transforms functionally and structurally according to how it is stimulated. Although this plasticity is much more intense during the development period, it continues to exist throughout our lives [2,3]. Therefore, keeping the brain stimulated during adulthood and aging is key to keeping cognition functioning at its best. In this context, recent studies indicate that certain stimuli help in the development of a cognitive reserve [4]. This, in turn, is the brain’s resilience capacity, which helps it to remain functional even throughout aging and even when some neurodegenerative diseases arise [5].

Sep 27, 2023

Nanopore sequencing and DNA barcoding method gives hope of personalized medicine

Posted by in category: biotech/medical

With the ability to map dozens of biomarkers at once, a new method could transform testing for conditions including heart disease and cancer.

Currently, many diseases are diagnosed from blood tests that look for one (such as a protein or other small molecule) or, at most, a couple of biomarkers of the same type.

The new method, developed by scientists at Imperial College London in a research collaboration with Oxford Nanopore Technologies (Oxford Nanopore), can analyze dozens of biomarkers of different types at the same time. This would potentially allow clinicians to gather more information about a patient’s disease.

Sep 27, 2023

Alien life, unlike humans, may not be carbon-based, suggests new study

Posted by in categories: alien life, chemistry

In a new study, self-sustaining chemical reactions were discovered which carry the potential to support alien life, which is very different from the elements present on Earth.

The biology of Earth hinges on organic compounds which comprise carbon along with elements like phosphorus, sulphur, nitrogen, oxygen and hydrogen. Scientists believe that alternative chemical frameworks can lead to the existence of alien life forms.

For long, scientists have wondered if alien life might evolve on the basis of significantly different chemistry. Researchers have speculated if silicon may work as a backbone for biology.

Sep 27, 2023

Stanford’s new microchip could put powerful AI on your devices

Posted by in categories: health, robotics/AI, wearables

Aside from faster results, edge computing has the added benefit of increased privacy: If your health information never leaves your wearable, you don’t have to worry about someone else intercepting it — or interfering with it — en route.

So why do we run these apps in the cloud, instead of locally? The problem is that wireless devices have limited processing power and battery — to run a more advanced and energy-intensive AI program, you may have to turn to huge servers in the cloud.

A Stanford-led team has now unveiled NeuRRAM, a new microchip that could let us run advanced AI programs directly on our devices.

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