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The Host Immune Response to Enterovirus A71 (EV-A71): From Viral Immune Evasion to Immunopathology and Prognostic Biomarkers of Severe Disease—A Narrative Review

Enterovirus A71 (EV-A71) is a critical global pathogen, primarily causing Hand-Foot-and-Mouth Disease (HFMD) but frequently leading to severe neurological complications, including fatal neurogenic pulmonary edema (PE). This review elucidates the complex interplay between viral pathogenesis and the host immune response. EV-A71 utilizes receptors like SCARB2 and PSGL-1 for entry, while its proteases (2Apro, 3Cpro) efficiently evade innate immunity by cleaving key signaling adaptors (MAVS, TRIF), suppressing Type I IFN response. Critical to disease progression is the age-dependent vulnerability in infants and the subsequent shift toward immunopathology. Severe disease is driven by a systemic cytokine storm and T cell dysregulation, characterized by a loss of control from Treg cells and a profound Th17/Treg imbalance, resulting in high levels of pathogenic cytokines (e.g., IL-17A, IFN-γ).

Scientists built a battery-free device that turns sunlight into fuel

Scientists have developed an artificial photosynthesis system that essentially regulates itself, eliminating the need for batteries used in many current designs. The key innovation is an electrolyzer that automatically adapts to changing sunlight by altering its electrical properties as it heats up. This keeps solar fuel production more stable while reducing cost and complexity.

From Supernova Physics to Fusion Energy: The Laser Experiments Changing Science — Dr. Mario Manuel

Fusion energy is no longer just science fiction — it’s becoming experimental reality. Dr. Mario Manuel, Ph.D. — General Atomics.

What if we could recreate the inside of a star — not in theory, but inside a laboratory on Earth using the world’s most powerful lasers?

Dr. Mario Manuel, Ph.D. is a plasma physicist and laser-science researcher at whose work sits at the frontier of fusion energy, laboratory astrophysics, high-energy-density physics, and advanced laser diagnostics. Trained in applied plasma physics and aerospace engineering, Dr. Manuel has spent his career developing new ways to visualize and understand the extreme electromagnetic environments created when ultra-powerful lasers interact with matter.

Dr. Manuel’s research has spanned some of the most ambitious scientific efforts underway today — from inertial fusion energy and plasma-instability control to recreating supernova-like shock waves in the laboratory and generating ultra-intense gamma-ray and particle beams using petawatt-class lasers.

Early in his career, Dr. Manuel helped pioneer advanced proton-radiography techniques capable of imaging invisible electric and magnetic fields inside laser-produced plasmas, work that opened new windows into the turbulent physics that can either enable or destroy fusion reactions.

Continue reading “From Supernova Physics to Fusion Energy: The Laser Experiments Changing Science — Dr. Mario Manuel” | >

Scientists think they solved the mystery of the Amaterasu particle

The mysterious Amaterasu particle may not be a proton at all. New research suggests that some of the most extreme cosmic rays could be ultraheavy atomic nuclei, heavier than iron, which are better able to retain their energy while traveling through space. This idea could help explain how these rare particles reach Earth and provide new clues about the powerful cosmic explosions that create them.

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