After the disastrous end of Midnight Society, Robert Bowling is back to try again.
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Russian physicists study laser beam compressed into thin filament
A group of Russian scientists recently presented their research into the process of laser pulse filamentation—the effect produced when a laser beam propagating in air focuses into a filament. The researchers discovered how this process influences the preliminary transition of a beam passing through quartz glass, which has applications in the field of nonlinear optics.
Light propagates in straight lines, and beams of light are only reflected or refracted to the side when the properties of the medium it is passing through change. This is the basis of linear optics: it is called ‘linear’ because the division of electric charges that occurs when light passes through a medium is linearly dependent on the intensity of the fields in the light wave itself. In other words, the stronger the electric field, the more the different charges are dispersed within the material—the material becomes polarized.
The polarization of a material should not be confused with the polarization of light. This polarization is characterised by the degree to which the positive and negative charges are dispersed in a substance, and in this way, the presence of specific directions within the electromagnetic wave within which the electric fields vibrate is called polarization.
Scientists Were Puzzled for Years by Mysterious Seafloor ‘Crop Circles’
Divers discovered strange geometric formations on the ocean floor in 1995. It took until 2011 to find the tiny, poisonous architect behind them—and we’re still unraveling why it builds them.
Cell-type resolved transcriptional network analysis of in vivo cellular senescence following injury
Senescence is a key manifestation of aging at the cellular level, caused by damage incurred by cells in time. In spite of their wide-ranging implications on how our multicellular bodies age, senescent cells are very challenging to identify due to their complex nature: many different aspects of cells are affected by this cellular state. This complicates defining clear criteria that help us decide whether a cell is senescent or not. In this paper, we propose a computational pipeline that enables us to identify a small subset of genes associated with senescence. The method combines two approaches commonly used in the study of networks, community detection and node centrality, and applies them to gene expression data obtained from the muscle tissue of mice after damage. The results obtained can contribute to establish the molecular correlates of a complex cellular state such as senescence.
Citation: Sabalic A, Moiseeva V, Cisneros A, Deryagin O, Perdiguero E, Muñoz-Cánoves P, et al. (2026) Cell-type resolved transcriptional network analysis of in vivo cellular senescence following injury. PLoS Comput Biol 22: e1014429. https://doi.org/10.1371/journal.pcbi.
Editor: Christoph Kaleta, Christian Albrechts Universitat zu Kiel, GERMANY.
