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Yann LeCun joins Logical Intelligence as founding chair of research board for energy based AI reasoning

US-based artificial intelligence (AI) startup Logical Intelligence has appointed Yann LeCun, former chief AI scientist at Meta, as the founding chair of its Technical Research Board, the company announced on January 22.

LeCun, one of the world’s most influential AI researchers and a Turing Award winner, left Meta late last year to launch his own startup, Advanced Machine Intelligence Labs, focused on building “world models” that can understand and navigate the physical environment. His decision to join Logical Intelligence signals a growing interest in alternatives to large language models for high-risk, real-world systems.

The company, founded by Eve Bodnia, also announced its flagship reasoning engine, Kona 1.0. A live public demonstration of Kona has been released on the company’s website.

Neuropsychiatric symptoms in cognitive decline and Alzheimer’s disease: biomarker discovery using plasma proteomics

Placental toxicology progress!

Commonly used in vitro and in vivo placental models capture key placental functions and toxicity mechanisms, but have significant limitations.

The physiological relevance of placental models varies, with a general hierarchy of simple in vitro complex in vitro/ organ-on-chip in vivo, but species-of origin considerations may alter their relevance to human physiology.

Cellular, rodent, human, and computational modeling systems provide insights into placental transport, physiology, and toxicology linked to maternal–fetal health.

Recent advances in 3D culture and microfluidic technologies offer more physiologically relevant models for studying the placenta.

Mathematical modeling approaches can integrate mechanistic physiological data and exposure assessments to define key toxicokinetic parameters.

Environmental chemical concentrations and omic data obtained from placental tissues can link toxicant influences on placental function to adverse birth outcomes.

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The Most Terrifying Alien Civilization Scenarios That Might Actually Be Real

This video explores alien societies capable of expanding across star systems, reshaping reality for efficiency, harvesting cosmic resources at unimaginable scales, or operating with forms of intelligence so detached from human values that our survival would barely register as a variable.

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Researched, written, edited, and produced by the @thegreatabyss1 team.

Music produced by @IronCthulhuApocalypse (License Control).

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The 20 Largest Beings In All Of Fiction

What if I told you that Godzilla, planets, and even the universe itself aren’t anywhere near the biggest beings in fiction?

Across movies, anime, comics, mythology, and cosmic horror, there are aliens so massive that galaxies are decorations, universes are toys, and reality itself exists inside them.

In this video, we rank the 20 BIGGEST ALIENS EVER IN FICTION — strictly by SIZE, not power or popularity.
We start with continent-crushing monsters like Starro…
move through planet-eaters like Unicron and Galactus…
and end with omniversal entities so vast that everything you know exists within them.

From Norse mythology and Lovecraftian horror to Marvel, DC, anime, and sci-fi films, this list escalates FAST — and by the end, scale itself stops making sense.

👉 Which alien blew your mind the most?
Drop a comment, like the video, and subscribe for more insane size breakdowns, cosmic rankings, and fictional mega-structures.

Think bigger.

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J. Richard Gott — Why Did Our Universe Begin?

Make a donation to Closer To Truth to help us continue exploring the world’s deepest questions without the need for paywalls: https://shorturl.at/OnyRq.

That the universe began seems astonishing. What brought it about? What forces were involved? How did the laws of nature generate the vast expanse of billions of galaxies of billions of stars and planets in the structures that we see today? What new physics was involved? What more must we learn?

Free access to Closer to Truth’s library of 5,000 videos: http://bit.ly/376lkKN

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John Richard Gott III is a Professor of Astrophysical Sciences at Princeton University who is noted for his contributions to cosmology and general relativity.

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A new optical centrifuge is helping physicists probe the mysteries of superfluids

Physicists have used a new optical centrifuge to control the rotation of molecules suspended in liquid helium nano-droplets, bringing them a step closer to demystifying the behavior of exotic, frictionless superfluids.

It’s the first demonstration of controlled spinning inside a superfluid—researchers can now directly set the direction and frequency of the molecule’s rotation, which is vital in studying how molecules interact with the quantum environment at various rotational frequencies. The method was outlined this week by researchers at the University of British Columbia (UBC) and colleagues at the University of Freiburg in the journal Physical Review Letters.

“Controlling the rotation of a molecule dissolved in any fluid is a challenge,” said Dr. Valery Milner, associate professor with UBC Physics and Astronomy and lead author on the paper.

New Study Links Altered Cellular States to Brain Structure

Researchers at the Icahn School of Medicine at Mount Sinai have characterized how cellular senescence—a biological process in which aging cells change how they function—is associated with human brain structure in both development and late life. The study, published January 22 in Cell, provides new insight into how molecular signatures of cellular senescence that are present during development and aging mirror those associated with brain volume and cortical organization.

Understanding brain structure is a central challenge in neuroscience. Although brain structure changes throughout life and is linked to both aging and neurodegenerative conditions such as Parkinson’s and Alzheimer’s diseases, the underlying molecular processes involved—including cellular senescence—are not defined. Cellular senescence is commonly defined as a state characterized by permanent cell cycle arrest in the absence of cell death, in which cells have altered function. While cellular senescence has been implicated in aging and disease, its role in shaping human brain structure—both during development and aging—has remained unclear.

“This is the first study to directly link senescence-related molecular networks in living human brain tissue to measurable differences in brain structure within the same individuals,” said Noam Beckmann, PhD, Director of Data Sciences and founding member for the Mount Sinai Clinical Intelligence Center, Assistant Professor of Artificial Intelligence and Human Health, and co-senior author of the paper. “By identifying molecular pathways that are engaged in both brain structure development and aging, our work highlights senescence as a fundamental biological feature of brain aging and neurodegenerative disease and helps prioritize targets for future experimental research aimed at protecting brain health.”

Researchers unlocked a new shortcut to quantum materials

Scientists are learning how to temporarily reshape materials by nudging their internal quantum rhythms instead of blasting them with extreme lasers. By harnessing excitons, short-lived energy pairs that naturally form inside semiconductors, researchers can alter how electrons behave using far less energy than before. This approach achieves powerful quantum effects without damaging the material, overcoming a major barrier that has limited progress for years.

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