Bosch and colleagues described that one-time AAV-FGF21 gene therapy in aged mice induced whole-body tissue-specific adaptations, including improved metabolic and mitochondrial function, restored proteostasis, and reduced adiposity, inflammation, fibrosis, and amyloidosis, thereby maintaining systemic cell fitness, preventing multi-organ age-related pathology, and prolonging health span.
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Human brain stimulation engages different gene programs in different cell types
Nature’s brief summary of a paper (by Moore et al.) which transcriptomically maps how electrical stimulation of ex vivo human brain tissue triggers a range of previously unknown gene expression programs.
Genetic signatures of stimulation coincide with the strengthening of cell assemblies in samples of human brain tissue.
Can AI Help Detect Disease Before Your Pet Gets Sick? | Dr. Ragen McGowan — Nestlé Purina
Can AI tell how your pet feels? Dr. Ragen McGowan, Ph.D. — Director of Global Digital & AI Product Development, Nestlé Purina North America.
What if your dog or cat could tell you how they’re feeling?
Today, artificial intelligence may be giving us a new way to listen.
By continuously monitoring things like activity, eating, sleep, elimination and other behaviors, AI can begin to establish what’s normal for an individual animal — and potentially detect subtle changes that humans would never notice.
Dr. Ragen McGowan, Ph.D. is Director of Global Digital & AI Product Development at Nestlé Purina (https://www.purina.com/pet-experts/rm…
Skull channels as gateways for immune surveillance of the brain
The central nervous system (CNS), once considered immune privileged, is, in fact, protected by a dynamic immune compartment located in the meninges. These immune cells are crucial for brain protection, controlling neuroinflammation, and also supporting neural function. Recent studies show that meningeal immune cells, including myeloid and B cells, partly originate from the skull bone marrow, which communicates directly with the meninges via specialized skull channels identified in mice and humans. These channels allow immune cell trafficking and cerebrospinal fluid (CSF) exchange, positioning the skull marrow as a CSF-sensing niche. Therefore, understanding skull–meninges–brain interactions reveals a functional connection between bone marrow and the CNS, offering new insights into neuroimmune regulation and potential therapeutic strategies in neuroinflammatory conditions.
Jessica Radley: A New Biostasis Option
The CEO of Nectome discusses the cryo-chemo option they offer
Galactic Gems Glisten in New Gallery From NASA’s Chandra
This gallery displays a collection of 16 galactic images from Chandra and other telescopes. Astronomers put galaxies into three main categories: spirals like our own Milky Way, ellipticals that are older and likely the results of mergers, and irregulars that can encompass a wide range of galactic phenomena. All types are represented in this collection. Each galactic image contains X-ray data from Chandra combined with data from telescopes such as NASA’s Webb, Hubble, IXPE, Swift, and NuSTAR, and others both in space and on the ground.
