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The Immune Chain Reaction That Raises Colon Cancer Risk in IBD

A hidden immune cascade linking the gut and bone marrow may explain how IBD turns inflammation into colon cancer.

Scientists at Weill Cornell Medicine have identified a complex immune process in the gut that may help explain why people with inflammatory bowel disease (IBD) face a much higher risk of colorectal cancer. The preclinical study shows how a specific immune signal can trigger a wave of white blood cells from the bone marrow into the gut, creating conditions that support tumor growth. The findings also suggest new approaches for detecting disease activity, tracking risk, and developing future treatments.

The role of TL1A in gut inflammation.

MIT Engineers Design Nanoparticles That Stimulate the Immune System to Attack Cancer Tumors

A Boost for Cancer Immunotherapy One promising strategy to treat cancer is stimulating the body’s own immune system to attack tumors. However, tumors are very good at suppressing the immune system, so these types of treatments don’t work for all patients. MIT engineers have now come up with a wa

Scientists Create “Off-the-Shelf” Cartilage That Safely Guides the Body To Regrow Bone

A new study shows that engineered, cell-free cartilage can safely support bone regeneration without provoking immune rejection. New research suggests it may be possible to repair major bone damage using a tissue implant that contains no living cells. By relying on the body’s own repair machine

Detection of THC Impairment Using Functional Near-Infrared Spectroscopy

Among adults receiving oral THC, portable fNIRS scans detected impairment with higher accuracy and fewer false positives than field sobriety tests, supporting fNIRS as a more objective approach for cannabis impairment detection.

This crossover trial compares the accuracy of resting-state functional near-infrared spectroscopy vs standard field sobriety testing to detect ∆9-tetrahydrocannabinol (THC) impairment among adults who use cannabis.

Uncovering genetic interactions in the DNA repair network in response to endogenous damage and ionizing radiation

Nebenfuehr et al. perform a combinatorial CRISPR-Cas9 screen targeting 461 DNA damage response genes under basal and irradiated conditions. The study maps thousands of genetic interactions, generating a rich resource to uncover mechanisms of genome maintenance and inspire future studies.

Missing Link Between Parkinson’s Protein And Damage to Brain Cells Discovered

An investigation by researchers from Case Western Reserve University School of Medicine in the US has filled in a missing link between the toxic build-up of proteins in the neurodegenerative condition Parkinson’s disease and the death of critical brain cells.

The result of three years of research, the discovery connects alpha-synuclein proteins to a breakdown in mitochondrial function, both previously linked to Parkinson’s.

“We’ve uncovered a harmful interaction between proteins that damages the brain’s cellular powerhouses, called mitochondria,” says neuroscientist Xin Qi.

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