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What if immortality and god-like intelligence were just a few years away?
Renowned futurist and former Google engineer Ray Kurzweil predicts that humanity is rapidly approaching a \.
That is one of the stranger truths about human evolution. Some of the traits helping people survive now are not purely modern at all. They are remnants of older branches of humanity, carried forward because they still work.
Evolution needs variation, inheritance, and reproduction. Those conditions have not disappeared.
Long-term health studies that follow multiple generations indicate that natural selection is still acting in modern populations. Certain traits are associated with having more children, and over time those traits become more common. Patterns in the data point toward earlier childbirth and later menopause, which together extend the reproductive window. Other trends suggest shifts in metabolism, including lower cholesterol and blood pressure.
Watch more videos on this topic here: https://shorturl.at/eYLvNWhat is the relationship between consciousness and the nature of ultimate reality? Some say th…
Cas12a2 enzyme is programmed to identify specific RNA sequences rather than DNA. Upon successful recognition and binding to its target RNA, the protein undergoes a conformational change that unleashes indiscriminate collateral cleavage of intracellular DNA, effectively shredding the genetic material and inducing rapid cell death. In preclinical in vitro and in vivo models, a single administration of this targeted Cas12a2 system suppressed the proliferation of KRAS-mutated cancer cells by 50% and eliminated human papillomavirus (HPV)-infected cells with an efficacy exceeding 90%. Crucially, the intervention demonstrated high specificity, displaying no significant off-target cytotoxicity or damage to healthy tissue. This RNA-triggered DNA-shredding mechanism provides a highly adaptable and potent platform for oncology and virology, shifting the CRISPR paradigm from localized genetic correction to the targeted apoptosis of diseased cells, with future applications potentially expanding to target HIV and other robust infections.
Kadin Crosby, Ryan Jackson and colleagues report newly discovered details demonstrating how CRISPR Cas12a2 can be repurposed to discriminately kill cancer cells in the petri dish and in mice.
At the direction of President Donald J. Trump, the Department of War is overseeing a multiagency effort to expeditiously find, review, identify, declassify and publicly release unresolved Unidentified Anomalous Phenomena-related records and historical documents in the federal government’s possession./ meta name=.
A nicely concise paper on antibody-linked lipid nanoparticles which target hematopoietic stem and progenitor cells in vivo, important yet tricky cell types to transduce for hematological gene therapy.
Ex vivo autologous hematopoietic stem cell (HSC) gene therapy has provided new therapies for the treatment of hematological disorders. However, these therapies have several limitations owing to the manufacturing complexities and toxicity resulting from required conditioning regimens. Here, we developed a c-kit (CD117) antibody-targeted lipid nanoparticle (LNP) that, following a single intravenous injection, can deliver RNA (both siRNA and mRNA) to HSCs in vivo in rodents. This targeted delivery system does not require stem cell harvest, culture, or mobilization of HSCs to facilitate delivery. We also show that delivery of Cre recombinase mRNA at a dose of 1 mg kg–1 can facilitate gene editing to almost all (∼90%) hematopoietic stem and progenitor cells (HSPCs) in vivo, and edited cells retain their stemness and functionality to generate high levels of edited mature immune cells.