Email: [email protected]. Or to: Bo Yang, 1,500 E Medical Center Dr., 5,144 Frankel Cardiovascular Center, Ann Arbor, Michigan, 48,109, USA. Email: [email protected].
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Attenuated Single Neuron and Network Hyperexcitability Following MicroRNA-134 Inhibition in Mice with Drug-Resistant Temporal Lobe Epilepsy
JNeurosci: Findings from Quintana-Sarti et al. help explain how targeting microRNA-134 in mice can reduce seizure activity and support the continued development of this novel RNA-based approach for the treatment of epilepsy.
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The multifactorial pathophysiology of acquired epilepsies lends itself to a multitargeting therapeutic approach. MicroRNAs (miRNA) are short noncoding RNAs that individually can negatively regulate dozens of protein-coding transcripts. Previously, we reported that central injection of antisense oligonucleotides targeting microRNA-134 (Ant-134) shortly after status epilepticus potently suppressed the development of recurrent spontaneous seizures in rodent models of temporal lobe epilepsy. The mechanism(s) of these antiseizure effects remain, however, incompletely understood. Here we show that intracerebroventricular microinjection of Ant-134 in male mice with preexisting epilepsy caused by intra-amygdala kainic acid-induced status epilepticus potently reduces the occurrence of spontaneous seizures.
Oxidative Stress and Neuroinflammation in Parkinson’s Disease: The Role of Dopamine Oxidation Products
Parkinson’s disease (PD) is a chronic neurodegenerative condition affecting more than 1% of people over 65 years old. It is characterized by the preferential degeneration of nigrostriatal dopaminergic neurons, which is responsible for the motor symptoms of PD patients. The pathogenesis of this multifactorial disorder is still elusive, hampering the discovery of therapeutic strategies able to suppress the disease’s progression. While redox alterations, mitochondrial dysfunctions, and neuroinflammation are clearly involved in PD pathology, how these processes lead to the preferential degeneration of dopaminergic neurons is still an unanswered question. In this context, the presence of dopamine itself within this neuronal population could represent a crucial determinant.
Transparent cooling film cuts car cabin temperature by 6.1°C without electricity
A transparent radiative cooling film technology that dissipates heat directly to the outside without consuming electricity has been developed to reduce vehicle overheating during summer. The technology was validated through real-vehicle experiments conducted under diverse conditions—including different countries, seasons, and both parking and driving scenarios—and demonstrated the ability to lower cabin temperatures by up to 6.1°C and reduce cooling energy consumption by more than 20%.
Seoul National University College of Engineering announced that a research team led by Prof. Seung Hwan Ko (Department of Mechanical Engineering, SNU), in collaboration with Prof. Gang Chen at MIT and research teams from Hyundai Motor Company and Kia (Materials Research & Engineering Center and Thermal Energy Total Development Group), has designed and fabricated a large-area Scalable Transparent Radiative Cooling (STRC) film applicable to vehicle windows. Through real-vehicle evaluations conducted under various climatic and driving conditions, the team demonstrated both energy-saving and carbon reduction effects.
This research was published online on February 4 in the journal Energy & Environmental Science.
Q&A: Will agentic AI replace human scientists?
An emerging type of artificial intelligence, known as “agentic” AI, seems to do everything that biomedical scientists do—and often, does it faster. This next-generation technology can interpret experimental data, report the results and make decisions on its own. But is agentic AI smart enough to replace actual scientists?
Jason Moore, Ph.D., chair of the Department of Computational Biomedicine at Cedars-Sinai, discusses the pluses and minuses of agentic AI. Moore is corresponding author of a new paper, published in Nature Biotechnology, that examines where agentic AI is today and where it is headed.
Education Gap Tied to Higher Risk for Young-Onset CRC Death
In a cross-sectional study of adults aged 25–49 years in the US, colorectal cancer (CRC) mortality rose from 1994 to 2023, primarily among those with 15 or fewer years of education, and educational disparities in mortality widened over time. More on the study.
Researchers analyze trends in colorectal cancer mortality among adults aged 25–49 years in a study spanning about three decades.