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Genetic Bottlenecks — How Few People Can Start a World? Or Restart One?

When disaster leaves only a handful, can a civilization restart? We explore genetic bottlenecks, colony failure, and the limits of survival.

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Watch my exclusive video Surviving a New Ice Age: https://nebula.tv/videos/isaacarthur–… out Practical Engineering: https://nebula.tv/practicalconstructi… 🛒 SFIA Merchandise: https://isaac-arthur-shop.fourthwall… 🌐 Visit our Website: http://www.isaacarthur.net ❤️ Support us on Patreon: / isaacarthur ⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a… 👥 Facebook Group: / 1,583,992,725,237,264 📣 Reddit Community: / isaacarthur 🐦 Follow on Twitter / X: / isaac_a_arthur 💬 SFIA Discord Server: / discord Credits: Genetic Bottlenecks – How Few People Can Start a World? Or Restart One? Written, Produced & Narrated by: Isaac Arthur Select imagery/video supplied by Getty Images Chapters 0:00 Intro 10:56 Restoration 19:26 Practical Engineering.
Check out Practical Engineering: https://nebula.tv/practicalconstructi…

🛒 SFIA Merchandise: https://isaac-arthur-shop.fourthwall…
🌐 Visit our Website: http://www.isaacarthur.net.
❤️ Support us on Patreon: / isaacarthur.
⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a…
👥 Facebook Group: / 1583992725237264
📣 Reddit Community: / isaacarthur.
🐦 Follow on Twitter / X: / isaac_a_arthur.
💬 SFIA Discord Server: / discord.
Credits:
Genetic Bottlenecks – How Few People Can Start a World? Or Restart One?
Written, Produced & Narrated by: Isaac Arthur.
Select imagery/video supplied by Getty Images.

Chapters.
0:00 Intro.
10:56 Restoration.
19:26 Practical Engineering

Many minds, not many worlds, constitute quantum reality

A century after the birth of quantum mechanics, many are still puzzled by the idea that Schrödinger’s cat is simultaneously alive and dead. The mystery drives some of our most prominent physicists to embrace the bizarre idea that reality constantly splits into a near infinity of parallel worlds, of which ours is just one. Philosopher of physics Nadia Blackshaw argues that this “many worlds” interpretation goes wrong not only in its extravagant multiplying of entities, but in its attempt to adopt a “view from nowhere,” describing reality from no particular perspective. She proposes instead a “many minds” interpretation, in which the cat is alive from one perspective and dead from another. It’s time physics took conscious perspectives seriously.

Glial Cells as Emerging Therapeutic Targets in Neurodegenerative Diseases: Mechanistic Insights and Translational Perspectives

Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease, multiple sclerosis, and amyotrophic lateral sclerosis share converging mechanisms of neuronal dysfunction, including protein aggregation, oxidative stress, and chronic neuroinflammation. Glial cells, once considered passive supporters, are now recognized as central drivers of these processes, offering both pathogenic triggers and therapeutic opportunities. Yet, despite compelling preclinical evidence, the translation of glial-targeted therapies into clinical success has been limited. This review provides a critical synthesis of current knowledge by examining therapeutic strategies through the lens of their translational challenges and failures.

Insular input to the prelimbic cortex underlies social affective behavior in rats

Delayed onset of hemichorea and dystonia can occur after cortical temporal Stroke, even when imaging reveals small acute ischemic lesions and routine blood tests are normal.

This case report describes delayed hemichorea-dystonia following right carotid endarterectomy for proximal internal carotid artery stenosis in a 79-year-old man.

Curriculum Innovation: Neurocritical Care EEG RoundsA Model to Improve Neurology Resident EEG Interpretation

Curriculum innovation: neurocritical care EEG rounds—a model to improve neurology resident EEG interpretation.

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Efficacy of Pyridostigmine in Myasthenia GravisA Randomized, Double-Blind, Placebo-Controlled Crossover Trial

Class I evidence that, in adults with AChRAb+ ocular or generalized myasthenia gravis (MG) on stable standard-of-care therapy and currently using pyridostigmine, pyridostigmine improves MG symptoms compared with placebo.

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Genetic Landscape and Diagnostic Outcomes of UK Patients With Congenital Myopathies and Muscular Dystrophies Over a 10-Year Period

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Case Fatality of Subarachnoid Hemorrhage by Aneurysm LocationA Population-Based Study From Finland and New Zealand

Case fatality of subarachnoid hemorrhage by aneurysm location a population-based study from finland and new zealand.

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Middle-Aged Carotid Plaque and Cognitive Functions in Later LifeA Population-Based Study

In this large cohort study, carotid plaque status at baseline was independently associated with in cognitive function decline, especially in nonverbal memory and executive functioning over 8-year follow-up period in the general population.

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