Researchers at the University of Bayreuth and Forschungszentrum Jülich have demonstrated that specific light-sensitive enzymes—so-called sensor histidine kinases (SHKs)—transmit their signal through a light-controlled change in asymmetry. With their new study, the researchers contribute to a better understanding of a central mechanism of bacterial signal processing. This may help develop new tools for biomedicine or biotechnology. The findings are reported in the journal Science Advances.
SHKs are key bacterial signaling proteins that play an important role in many processes, from controlling which genes are active at a given time to enabling the ability to cause disease. Artificially engineered light-sensitive SHKs are also used in optogenetics to precisely control gene activity with light. However, only limited structural information has been available so far for the full protein.
The new study provides important insights into how natural and engineered SHKs transmit signals across multiple protein domains. In the long term, the study may help develop new optogenetic tools that allow biological processes to be precisely controlled using light. This is particularly relevant for applications in biotechnology and biomedicine.
