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Possible therapeutic approach to treat diabetic nerve damage discovered

Nerve damage is one of the most common and burdensome complications of diabetes. Millions of patients worldwide suffer from pain, numbness, and restricted movement, largely because damaged nerve fibers do not regenerate sufficiently. The reasons for this are unclear.

A research team led by Professor Dr. Dietmar Fischer, Professor of Pharmacology at the University of Cologne’s Faculty of Medicine, and Director of the Center for Pharmacology at University Hospital Cologne, has now identified a central mechanism that explains limited regeneration in diabetes.

Building on this, the researchers have developed a promising therapeutic approach that can be used to increase regeneration. Their findings were published in the Science Translational Medicine journal under the title “Failure of nerve regeneration in mouse models of diabetes is caused by p35-mediated CDK5 hyperactivity.”

Sensor-integrated food wrapper can facilitate real-time, non-destructive detection of nutritional components

Food quality and safety are crucial. However, conventional food-monitoring methods, including ribotyping and polymerase chain reaction, tend to be destructive and lengthy. These shortcomings limit their potential for broad applications. In this regard, surface-enhanced Raman scattering (SERS) sensing, with real-time, non-destructive, and high sensitivity capabilities, is a highly promising alternative.

In a new breakthrough, a team of researchers, led by Associate Professor Ji-Hwan Ha from the Department of Mechanical Engineering, Hanbat National University, Republic of Korea, has developed a two-in-one nanostructured SERS sensor integrated into a stretchable and antimicrobial wrapper (NSSAW) that not only monitors food directly on the surface but also actively preserves it.

Their novel findings are published in the journal Small.

Exceptional points alter the order of lasing modes

Exceptional points (EPs) are non-Hermitian singularities where two or more eigenstates coalesce, resulting in the eigenspace collapsing in dimensionality. Over the past decade, researchers have uncovered a wealth of exotic phenomena near EPs.

In laser physics, for example, EPs have been linked to pump-induced laser termination, loss-induced lasing, and the design of quasi-parity-time-symmetric laser systems that boost the output power of large-area lasers while preserving single-mode operation.

Meteorite crater hosts methane-making microbes—a clue to life on Mars?

Scientists have discovered living microbes producing methane in the fractured rocks deep inside Sweden’s Siljan impact crater, offering insights into Earth’s earliest life and the search for life beyond our planet.

This breakthrough not only sheds light on one of Earth’s most ancient metabolic processes —methanogenesis—but also strengthens the link between meteorite impact structures and microbial survival in extreme environments. The findings are published in the journal mBio.

Methanogenesis is considered one of the earliest metabolisms on Earth, and its presence in deep subsurface environments has long intrigued scientists. Now, for the first time, active microbial methane production has been confirmed in a terrestrial impact crater. Using cultures enriched from fluids 400 meters below the surface, the team demonstrated methane generation from several carbon sources, including indigenous oil.

Non-toxic solvent enables near-perfect recycling of mixed-fiber textiles

We are producing more textiles than ever before: worldwide, well over one hundred million tons of textiles are manufactured every year—more than twice as much as in the year 2000. This makes it increasingly important not to simply throw away old textiles, but to recover them in an environmentally friendly way.

That is often not easy—especially when it comes to blended fabrics, such as mixtures of cotton and polyester. At TU Wien, a new method has now been developed to separate and recycle such mixed textiles efficiently—in a remarkably simple way, using menthol and benzoic acid, two nontoxic substances.

The research is published in the journal Waste Management.

Ultrafast UV-C laser pulses generated and detected using 2D materials

Scientists have developed a new platform for the generation and detection of ultrashort UV-C laser pulses on femtosecond timescales. This breakthrough could unlock new opportunities for transforming optical wireless communication systems, material processing applications and medical imaging.

Scientists from the University of Nottingham’s School of Physics and Astronomy and Imperial College London developed the new platform. The source produces pulses of femtosecond duration, less than 1 trillionth of a second. These pulses are detected at room temperature by sensors based on ultrathin (two-dimensional, 2D) materials. The paper is published in the journal Light: Science & Applications.

Professor Amalia Patané, from the School of Physics and Astronomy at the University of Nottingham, led the development of the sensors. “This work combines for the first time the generation of femtosecond UV-C laser pulses with their fast detection by a new class of 2D semiconductors. These can operate over a wide range of pulse energies and repetition rates, as required for many applications,” says Patané

Physicists Rewrite Thermodynamics for the Quantum Age

Researchers have devised a new way to define thermodynamic concepts in microscopic quantum systems, where conventional distinctions between heat and work begin to blur. Researchers at the University of Basel have introduced a new way to apply thermodynamic principles to very small quantum systems

Astronomers Discover a Star That Breaks the Rules Orbiting a Silent Black Hole

Astronomers have uncovered clues to a red giant’s chaotic past by detecting subtle stellar vibrations that hint at a long-ago collision and an unexpectedly rapid spin. Astronomers at the University of Hawaiʻi Institute for Astronomy (IfA) have pieced together the turbulent history of a distant re

Beyond Einstein: Could Our Universe Have Seven Hidden Dimensions?

The geometry of space, the setting in which physical laws operate, may hold clues to some of the biggest unanswered questions in fundamental physics. The underlying structure of spacetime itself could be the foundation for every interaction observed in nature. A study published in Nuclear Physics

Dark Matter May Have Finally Been Detected in Our Galaxy’s Glow

A strange, never-before-seen glow in the halo of our galaxy may be the strongest dark-matter breadcrumb yet.

A new analysis of 15 years’ worth of data from the Fermi Gamma-Ray Space Telescope reveals a glow of unusually high-energy gamma rays that cannot easily be attributed to any known source.

According to astronomer Tomonori Totani of the University of Tokyo in Japan, it may be the radiation produced when hypothetical dark matter particles collide and wipe out one another.

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