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Targeting enzyme could block cancer spread to brain with fewer side effects

A new study has identified a more precise and effective way to prevent cancer from spreading to the brain. The paper, published in the Proceedings of the National Academy of Sciences, details the development of novel drug candidates that target a key enzyme implicated in the spread of lung, breast, skin and other cancers to the brain. The work builds on a promising new therapeutic strategy first reported by the same group of researchers last year.

The new drug candidates are designed to intercept rogue cancer cells before they depart from primary tumors and ultimately travel to the brain.

Lead author Sheila Singh, based at both King’s College London and McMaster University, says this type of cancer—called metastatic brain cancer—is the most common type of brain tumor in adults and comes with an extremely grim outlook, with 90% of patients dying within one year of diagnosis.

These tiny genetic fragments may be critical for telling a brain when to rest

The altered presence of tiny fragments of neuronal genes, called microexons, causes hyperarousal in zebrafish. This is the main conclusion of an international study led by Pompeu Fabra University (UPF) and the Center for Genomic Regulation (CRG). An abnormal pattern of neural microexon presence leads to a hyperarousal state characterized by heightened neural activity and insomnia, commonly associated with stress but also with neurodevelopmental disorders.

Arousal regulation is highly conserved in evolution. Therefore, this finding could help researchers understand the mechanism underlying some human neurodevelopmental disorders, such as autism and schizophrenia, conditions associated with microexon mutations.

To survive, animals need to be ready to react to external and internal stimuli. This activation of the central nervous system, arousal, is highly conserved throughout the animal kingdom.

Social Determinants of Health and Neurobiology Across the Schizophrenia Course: A Systematic Review

This systematic review examines structural, functional, neurochemical, and plasticity brain changes associated with social determinants of health in individuals with, or at risk for, schizophrenia-spectrum psychotic conditions.

Engineering RH

Engineering Riemann Hypothesis

This morning, I revisited the Riemann Hypothesis from a zero–pole perspective 🧮✨ and introduced a new reciprocal formulation called the Srichan Teza Function. https://lnkd.in/gkFRTfX3 The idea is simple 🔄: Start from the completed zeta function ξ(s) = 1/2 · s(s − 1)π⁻ˢᐟ² Γ(s/2)ζ(s) and define T_S(s) = 1/ξ(s) Then every zero of ξ(s) becomes a pole of T_S(s): ξ(ρ) = 0 ⇔ T_S(s) has a pole at s = ρ So RH can be reframed as a pole-localization problem 🕳️📍: All poles of T_S(s) in the critical strip must lie on Re(s) = 1/2 Using the argument principle 🔁, P_T(D) = 1/(2πi) ∮∂D ξ′(s)/ξ(s) ds counts the number of Teza poles inside a domain D. Geometrically, this is the winding number of the curve ξ(∂D) around the origin 📐🌀

Submit an Abstract — 2026 International Mars Society Convention

The 2026 International Mars Society Convention is now accepting abstract submissions for presentations covering all aspects of Mars exploration and settlement.

We welcome proposals across a wide range of topics, including science, engineering, technology development, human factors, public policy, economics, and other key areas shaping the future of the Red Planet.

This global gathering will bring together scientists, engineers, policymakers, industry leaders, and space advocates to share ideas, research, and strategies for advancing human exploration of Mars. Whether your work is technical, conceptual, or interdisciplinary, we encourage you to contribute to the conversation.

UNM Researchers Find Alarmingly High Levels of Microplastics in Human Brains — and Concentrations are Growing Over Time

Microplastics – tiny bits of degraded polymers that are ubiquitous in our air, water and soil – have lodged themselves throughout the human body, including the liver, kidney, placenta and testes, over the past half century.

Now, University of New Mexico Health Sciences researchers have found microplastics in human brains, and at much higher concentrations than in other organs. Worse, the plastic accumulation appears to be growing over time, having increased by 50% over just the past eight years.

In a new study published in Nature Medicine, a team led by toxicologist Matthew Campen, PhD, Distinguished and Regents’ Professor in the UNM College of Pharmacy, reported that plastic concentrations in the brain appeared higher than in the liver or kidney, and higher than previous reports for placentas and testes.

Douglas Hofstadter: The Nature of Categories and Concepts

Stanford Symbolic Systems Distinguished Speaker Lecture Thursday, March 6, 2013.

Douglas Hofstadter, College of Arts and Sciences Distinguished Professor of Cognitive Science and Comparative Literature. Indiana University.

What is a quintessential category? Bird, perhaps? Or maybe chair? And what is a quintessential concept? Two? Number? Prime number?

I’m not trying to put words into your mouth — I’m just trying to get you to ask yourself these questions. Also, I wonder if by any chance you thought that these are really exactly the same question, in which case you might have wondered why I asked you the same question twice.

Or did you perhaps think something along these lines: \.

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