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Resurrected 3.2-Billion-Year-Old Enzyme Could Unlock the Origins of Life

Nitrogen is essential for life on Earth, yet most organisms cannot use it directly from the atmosphere. Scientists now believe this element may also provide important clues about how life first developed on our planet and how it might arise elsewhere in the universe.

“All living organisms need nitrogen to survive and, though it’s all around us, we can’t access it directly,” says Utah State University biochemist Lance Seefeldt. “Enzymes called nitrogenases enable nitrogen fixation, which converts nitrogen to a form plants, animals, humans, and other life forms can access. And we’re just beginning to understand the extent to which, over the Earth’s four-billion-year history, these nitrogenases have evolved.”

Aura confirms data breach exposing 900,000 marketing contacts

Identity protection company Aura has confirmed that an unauthorized party gained access to nearly 900,000 customer records containing names and email addresses.

The company states that the incident was caused by a voice phishing attack targeting an employee, which exposed the sensitive data of 20,000 current and 15,000 former customers.

In a communication this week, Aura states that the data originated from a marketing tool used by a company acquired by Aura in 2021, which exposed limited information.

New “Darksword” iOS exploit used in infostealer attack on iPhones

A new exploit kit for iOS devices and delivery framework dubbed “DarkSword” has been used to steal a wide range of personal information, including data from cryptocurrency wallet apps.

DarkSword targets iPhones running iOS 18.4 through 18.7 and is linked to multiple actors, including UNC6353, suspected to be Russian, who used the Coruna exploit chain disclosed earlier this month.

Researchers at mobile security company Lookout discovered DarkSword while investigating the infrastructure used for the Coruna attacks. Google’s Threat Intelligence Group and iVerify also collaborated for a more comprehensive analysis of this previously unknown threat and the adversaries leveraging it.

Neuropsychiatric Symptoms in Patients With Pathologically Confirmed Comorbid Alzheimer Disease and Frontotemporal Lobar Degeneration

Background and ObjectivesLittle is known about the clinical presentation in patients with comorbid Alzheimer disease neuropathologic change (ADNC) and frontotemporal lobar degeneration (FTLD) neuropathology, despite frequent comorbidity of…

Hypoxia-inducible protein 2 mediates metabolic adaptation of Ly6ChighLy6Glow monocytes after stroke

New study from Weijie Chen, Xin Wang, Tingting Huang, Weifeng Yu.

Florent Ginhoux, Peiying Li (Shanghai Jiao Tong University) and colleagues identifies hypoxia-inducible protein 2 (HIG2) as a key regulator of anti-inflammatory property of Ly6ChighLy6Glow monocyte-derived macrophages in the ischemic brain after stroke through mediating phosphatidylcholine synthesis.


This study identifies hypoxia-inducible protein 2 (HIG2) as a key regulator of anti-inflammatory property of Ly6ChighLy6Glow monocyte-derived macrophages i.

USP10 Deubiquitinates MTX2 to Suppress cGAS-STING Signaling in MI

Zhao & colleagues found how a protective protein, USP10, helps limit excessive inflammation after a heart attack, which may open new avenues for treating cardiac injury. Learn more at.


BACKGROUND: Myocardial infarction (MI) results in 3 distinct regions within the left ventricle:

The infarct zone, the border zone (BZ), and the remote zone. A major focus of MI research.

Is investigating the intrinsic mechanisms in the BZ to alleviate myocardial injury.

USP10 (ubiquitin-specific peptidase 10) expression is reduced in BZ cardiomyocytes.

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