Exosomes have huge potential for drug delivery, but drug loading can be difficult. Here, the authors report on fusogenic lipid nanoparticles which, when mixed with exosomes rapidly fuse, non-destructively loading large drugs without compromising exosome biological functions, and demonstrate neurological application.
Rapidly maturing lab-grown human heart cells and tissues could open the door to better drug discovery and regenerative medicine.
What if everything around you — your phone, your chair, even the stars — has some form of consciousness? In our new video, we dive into mind-bending theories from scientists and philosophers that challenge how we see reality itself. This isn’t science fiction — it’s a serious debate shaking up physics, philosophy, and neuroscience. Could the entire universe be aware? And what does that mean for us? 🌀 Tap in and prepare to question everything you thought you knew about existence.
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Voltage imaging enables scientists to visualize neural activity using voltage-sensitive fluorescent sensors. What do you need for voltage imaging?
Detailed sources: https://docs.google.com/document/d/1Bn96eUI-Vh0DsIaHRxObnISL…sp=sharing.
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For centuries, scientists have grappled with the most fundamental question of them all — what is reality?Is it a matter of common sense? Or can God or some h…
The phrase “MRI for AI” rolls off the tongue with the seductive clarity of a metaphor that feels inevitable. Dario Amodei, CEO of Anthropic, describes the goal in precisely those terms, envisioning “the analogue of a highly precise and accurate MRI that would fully reveal the inner workings of an AI model” (Amodei, 2025, para. 6). The promise is epistemic X‑ray vision — peek inside the black box, label its cogs, excise its vices, certify its virtues.
Yet the metaphor is misguided not because the engineering is hard (it surely is) but because it mistakes what cognition is. An artificial mind, like a biological one, is not a spatial object whose secret can be exposed slice by slice. It is a dynamical pattern of distinctions sustained across time: self‑referential, operationally closed, and constitutionally allergic to purely third‑person capture. Attempting to exhaust that pattern with an interpretability scanner is as quixotic as hoping an fMRI might one day disclose why Kierkegaard chooses faith over reason in a single axial slice of BOLD contrast.
Phenomenology has warned us for more than a century that interiority is not an in‑there to be photographed but an ongoing enactment of world‑directed sense‑making. Husserl’s insight that “consciousness is always consciousness of something” (Ideas I, 1913) irreversibly welds experience to the horizon that occasions it; any observation from the outside forfeits the very structure it hopes to catch.
These are your rudimentary seed packages… Some will combine in place to form more complicated structures.’ — Greg Bear, 2015.
Robot Bricklayer Or Passer-By Bricklayer? ‘Oscar picked up a trowel. ‘I’m the tool for the mortar,’ the little trowel squeaked cheerfully.’ — Bruce Sterling, 1998.
Organic Non-Planar 3D Printing ‘It makes drawings in the air following drawings…’ — Murray Leinster, 1945.
Results from the VITAL randomized controlled trial reveal that vitamin D supplementation helps maintain telomeres, protective caps at the ends of chromosomes that shorten during aging and are linked to the development of certain diseases.
The new report, published in The American Journal of Clinical Nutrition, is based on data from a VITAL sub-study co-led by researchers at Mass General Brigham and the Medical College of Georgia, and supports a promising role in slowing a pathway for biological aging.
“VITAL is the first large-scale and long-term randomized trial to show that vitamin D supplements protect telomeres and preserve telomere length,” said co-author JoAnn Manson, MD, principal investigator of VITAL and chief of the Division of Preventive Medicine at Brigham and Women’s Hospital.
