Mongiovi, J.M., Babic, A., Sasamoto, N. et al. Ovarian cancer tumor immune profiles associated with intrauterine device and oral contraceptive use. Br J Cancer (2026). https://doi.org/10.1038/s41416-026-03508-9
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Imaging assessment of immunotherapy in pediatric brain tumors
Immunotherapy is a rapidly evolving field in pediatric neuro-oncology, using diverse strategies to enhance or initiate an antitumor immune response. Its use has expanded from hematologic malignancies to solid central nervous system (CNS) tumors, creating new diagnostic challenges in neuroimaging, particularly in children.
The aim of this review is to summarize current immunotherapeutic strategies for pediatric solid CNS tumors and to discuss their characteristic imaging findings and response patterns, with emphasis on pitfalls in differentiating true progression from treatment‑related inflammatory changes.
Across different immunotherapeutic approaches, a major challenge is distinguishing tumor progression from pseudoprogression, immune‑related flare phenomena, and neurotoxicity. Multiparametric imaging combining advanced MRI techniques and metabolic imaging may improve diagnostic specificity; however, validation in children is limited, and existing response frameworks such as iRANO and RAPNO do not specifically address immunotherapy‑related imaging patterns in the pediatric population.
Blood-based test can predict risk of developing symptoms of Alzheimer’s up to a decade early
A blood test for the biomarker phosphorylated tau 217 (p-tau217) recently received federal clearance, but questions have emerged about the extent to which such tests can accurately predict whether a cognitively healthy individual will develop cognitive impairment—a key symptom of Alzheimer’s disease.
A new international study involving researchers across three continents and led by experts from the Mass General Brigham Neuroscience Institute sheds new light on the prognostic value of such tests.
The study found that cognitively unimpaired individuals with very high levels of the biomarker had a 38% absolute risk of developing cognitive impairment over the next five years and a 78% risk over the next 10 years.
Parasites Are Causing Explosive Diarrhea to Surge. Here’s How to Avoid The Worst Ones
The thought of parasites in your food might make you squirm, but they are a reality we must all be wary of.
An outbreak of the parasite Cyclospora in the US, with most cases being reported in Michigan, is a stark reminder of how quickly parasites can spread, even in developed nations.
Michigan health officials have identified lettuce and salad greens as a potential vector for the parasite, since it is transmitted by food and water contaminated by feces.
Twisted ultrathin magnet retains magnetization after field changes, study finds
The properties of ultrathin magnets can be specifically altered by a slight twist between two atomic monolayers. This is the conclusion reached by an international research team led by TU Darmstadt in a study published in Nature Communications. The findings open new prospects for future memory devices.
For the first time, the researchers observed that an extremely thin magnetic material—a so-called two-dimensional van der Waals magnet—” stores” its magnetic state: It responds to a magnetic field and retains some of its magnetization even when the applied field changes. This “memory” is known as hysteresis and forms the basis of many data storage systems.
Frame-dragging observations validate Einstein yet again
More than a century after Albert Einstein first transformed our understanding of gravity, his general theory of relativity continues to withstand ever more demanding experimental tests. Now, an international team led by Ignazio Ciufolini at the Chinese Academy of Sciences has carried out the most precise measurement yet of one of the theory’s most subtle predictions: the dragging of spacetime caused by Earth’s rotation.
Published in Nature, the team’s results provide the strongest confirmation to date that Einstein’s description of gravity remains accurate even under extraordinarily precise scrutiny.
New technique for building ultra-thin material stacks promises quantum breakthrough
Scientists have unveiled a new fabrication technique for the ultra-clean manufacturing of 2D heterostructures—materials just a few atoms thick—that could be used in quantum technology and electronics. Experts from Southampton and Singapore say the method could be used to develop next-generation devices that accelerate research in quantum computing.
The research behind their technique, published in Nature Communications, was developed in collaboration between the Institute for Functional Intelligent Materials at the National University of Singapore and the University of Southampton.
Current manufacturing methods to build two-dimensional materials rely on sticky synthetic polymers to assemble the atomic layers. However, these often leave behind microscopic residues that contaminate the tiny structures and disrupt the performance of electronic devices that use them. The research team instead used the natural mineral muscovite, or mica, to stack the atomically thin materials together.
Physicists confirm 20-year-old theory that could boost quantum technology
Future quantum computing will require correlations between distant modules—a feature known as distributed entanglement. Traditionally, such entanglement has relied on active control and repeated measurements. Now, physicists at the Institute of Science and Technology Austria (ISTA) have realized a fully autonomous method for distributed entanglement using a “quantum bath” of correlated light particles. Published in Physical Review X, their work experimentally confirms a 20-year-old prediction and could provide a new platform for applied quantum technologies.
Entanglement is a central feature of quantum physics in which shared correlations exceed what classical theories can explain. Achieving distributed entanglement between physically separated qubits (quantum bits) could enable future advances, such as scalable quantum computers and quantum networks.
To entangle distant qubits, earlier attempts have relied on two protocols. In one approach, a single, actively controlled photon is sent from one qubit to the other. In the second approach, each qubit emits a photon that must be matched to produce entanglement. While the second method earned the 2022 Nobel Prize in Physics, it requires many repeated measurements and post-selection and still does not always yield entanglement.