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Light-triggered arrhythmia reveals rapid brain oxygen shifts in mice

An irregular heartbeat, or arrhythmia, leads to inefficient pumping of blood by the heart, which then prevents blood and oxygen from getting to the body’s other organs. When blood and oxygen flow poorly to the brain, the risk of stroke and cognitive decline increases.

A team of researchers based at Washington University in St. Louis used cardiac optogenetics to noninvasively study arrhythmia and its impact on the brain. Using highly sensitive imaging in a mouse model, they found that arrhythmia in a mouse heart alters oxygen concentration in the brain during and after arrhythmia.

Results of the research are published in Science Advances.

Cory Doctorow on AI: The Singularity Is A Progressive Apocalypse

Fourteen years ago, Cory Doctorow told me the #Singularity is a progressive apocalypse.

I have not stopped thinking about that phrase since.

We like to imagine the future as one clean break. A line crossed. A god booted up in a server farm. Cory saw something stranger. The end of the world, sold to us as the perfection of the world. Rapture for the people who swapped faith for code.

His sharpest point was about stories. Good #ScienceFiction does not predict the future. It predicts the present. The genre is not a telescope. It is a mirror.

Re-listening in 2026, the reflection is uncomfortable.

The surveillance he warned about is now infrastructure. The platforms he distrusted now mediate almost everything we do. We still treat the internet as a glorified video-on-demand service, and we still pour everything we are onto it anyway.

New study assesses Titan’s resources and their potential uses

Saturn’s largest moon, Titan, is a unique environment in our solar system. It is the only moon (or body beyond Earth) to have a dense, nitrogen-rich atmosphere, and its methane cycle is very similar to Earth’s hydrological cycle, in which solid and liquid methane evaporate to form clouds and return to the surface as precipitation. In addition, its prebiotic surface environment and rich organic chemistry make it a prime destination for astrobiology missions, such as NASA’s Dragonfly mission (set to launch no earlier than July 2028).

And as Robert Zubrin said in his book, “Entering Space: Creating a Spacefaring Civilization,” Saturn’s moons could become the “Persian Gulf” of the solar system, with Titan a major one because of its rich resource environment. In a recent NASA-supported study posted to the arXiv preprint server, a team of researchers compiled an inventory of Titan’s resources and their potential use by future generations of humans. When comparing this satellite with other destinations (i.e., the moon and Mars), they conclude that Titan offers several potential benefits for human settlement.

The research was led by Conor A. Nixon, an astronomer and planetary scientist with the solar system Exploration Division (SSED) at the NASA Goddard Space Flight Center and the associate laboratory chief of its Planetary Systems Laboratory. He was joined by Ye Lu, a professor of aerospace engineering at Worcester Polytechnic Institute, and Jennifer E. Ruliffson, a professor of Materials Science and Engineering at the University of Florida. Their paper is under review for publication in Acta Astronautica.

Fragile X deficits in mice respond to gene therapy

A gene therapy designed to replace a missing brain protein restored normal brain activity and improved behavior in a mouse model of fragile X syndrome (FXS), according to a study led by researchers at the University of California, Riverside. The findings, published in Molecular Therapy Nucleic Acids, suggest that gene therapy may one day address the underlying cause of FXS rather than simply treating its symptoms.

FXS affects approximately 2–3% of individuals diagnosed with autism and is one of the best-defined genetic causes of neurodevelopmental disability. The condition occurs when a mutation in the FMR1 gene prevents the production of fragile X messenger ribonucleoprotein (FMRP), a protein that regulates communication between brain cells.

“In a typical brain, FMRP acts like a brake or a volume control,” said Iryna Ethell, the paper’s senior author and a professor of biomedical sciences in the UCR School of Medicine. “Without it, neural circuits become overactive and less efficient, which contributes to many of the developmental and behavioral challenges associated with FXS.”

University of Chicago Just Found a Shortcut Quantum Computers Needed for Years

University of Chicago researchers may have found the shortcut quantum computers have needed for decades.

In this video, we break down a major quantum computing breakthrough involving QLDPC error correction codes, reconfigurable atom arrays, and movable neutral atoms controlled by laser light. This new approach could reduce the number of physical qubits needed for practical fault-tolerant quantum computing by a factor of ten to twenty.

That matters because quantum computers have always faced one massive problem: qubits are extremely fragile. Traditional surface-code error correction can require thousands of physical qubits just to protect one reliable logical qubit, pushing useful quantum computers decades into the future. But this new blueprint could bring the requirement down from millions of qubits to tens of thousands.

We also explain why this discovery could affect medicine, drug discovery, encryption, post-quantum cybersecurity, climate technology, materials science, artificial intelligence, and the global race to build real quantum machines.

This is not a finished quantum computer yet. It is a credible engineering roadmap through one of the biggest bottlenecks in the field. But it may move practical quantum computing much closer than experts expected.

Watch the full video to understand why this University of Chicago breakthrough could change the quantum timeline.

Quantum Paradoxes: 5 Ways to Test the Multiverse | Maria Violaris

Can we actually test whether the multiverse is real? Not just philosophicallybut scientifically?

Quantum physicist Maria Violaris presents five remarkable experiments, from Schrödinger’s cat to Google’s Willow quantum chip, that put the multiverse to the test. Along the way, she untangles two of the strangest phenomena in all of physics — quantum measurement and entanglement — and reveals how a thought experiment designed to test the multiverse in 1985 accidentally launched today’s billion-dollar quantum computing race.

Maria also shares a puzzling thought experiment of her own that overturns a long-held assumption: that you can never communicate across branches of the multiverse.

Join this channel to get access to Maria’s exclusive Member’s Only Q&A:
/ @theroyalinstitution.

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Maria Violaris is a quantum physicist and prize-winning science communicator with a PhD in the foundations of quantum information from the University of Oxford. She works on quantum theory research at Oxford Quantum Circuits, runs a YouTube channel and the Quantum Foundations Podcast, and pioneered the use of quantum thought experiments for quantum computing education through her Quantum Paradoxes series at IBM Quantum.

Scientists uncover a genetic ‘shield’ that lowers the risk of colorectal cancer

A team of scientists from the Barbara Ann Karmanos Cancer Institute, Wayne State University and institutions across the U.S. have published a new paper on the role of TGFBR1*6A, a naturally occurring genetic mutation in the TGFBR1 gene found in approximately 14% of the general population.

The study, “TGFBR1*6A and risk for colorectal cancer,” published June 9, 2026, in Cancer Communications, focuses on TGFBR1*6A and how it influences a person’s risk of developing colorectal cancer. Dr. Boris Pasche, president and CEO of the Karmanos Cancer Institute and chair of the Wayne State University Department of Oncology, was the first to discover TGFBR1*6A as a cancer risk allele.

“This mutation has often been overlooked by genome-wide association study chips, which cannot detect TGFBR1*6A, and is commonly missed by next-generation sequencing platforms due to the complexity of the region,” said Dr. Allan Johansen, a postdoctoral fellow and first author of the paper.

Faster aging, chronic disease linked to WTC responders with PTSD

Post-traumatic stress disorder (PTSD) remains a common condition affecting World Trade Center (WTC) responders 25 years after the attack on the Twin Towers. While the condition is considered mainly psychological, a new study sheds light on changes in the biological processes of WTC patients with PTSD that may explain why PTSD is associated with a variety of chronic diseases that ultimately contribute to aging.

Completed by a team of researchers affiliated with the Stony Brook World Trade Center Health and Wellness Program, which monitors the health of and provides patient care to some 10,000 WTC responders, and scientists at Duke University, the study is published in Nature Communications.

The work represents more than a decade of research led by Benjamin J. Luft, MD, senior author, the Edmund D. Pellegrino Professor of Medicine in the Renaissance School of Medicine (RSOM) at Stony Brook University and director of the WTC Health and Wellness Program; and Pei-Fen Kuan, Ph.D., first author and professor in the Department of Applied Mathematics and Statistics in the College of Engineering and Applied Sciences at Stony Brook University.

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