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The role of electrons and their negative charge in electric current is well established. Electrons also exhibit other intrinsic properties that are associated, for example, with considerable potential for enhancing data storage devices: the electron’s spin or magnetic moment.

To date, however, the selection of specific spins has been challenging. It has been difficult to single out only those electrons with an up-direction of spin, for example. One way of doing this would be to pass a current through a ferromagnet, such as iron. This would result in the generation of a current in which the aligns with the direction of the magnetic field.

The alternative option of inducing a current in chiral molecules, i.e., molecules that have no superimposable mirror images, such as helix structures, has been discussed over the past decade. The result is spin polarization of approximately 60–70%, a level similar to that achieved in ferromagnetic materials. However, this approach remains a subject of ongoing debate and research.

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People with shorter telomeres — the protective caps at the ends of their chromosomes — may have a higher risk of developing age-related brain diseases such as stroke, dementia, and late-life depression (typically diagnosed at age 60 or older). This finding comes from a preliminary study set to be presented at the American Stroke Association’s International Stroke Conference 2025, a leading global event for stroke and brain health research, taking place in Los Angeles from February 5–7, 2025.

Telomere length in white blood cells (leukocytes), known as leukocyte telomere length, is a well-established marker of biological aging. As people age, telomeres naturally shorten, reducing their ability to protect chromosomes, which accelerates cellular aging and increases vulnerability to age-related diseases. While telomere length is partly determined by genetics, ancestry, and gender, it is also influenced by lifestyle factors and environmental stressors such as diet, exercise, and pollution.

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Amid the swirling vastness of galaxies, each a cosmic city of stars and planets, the silence raises a compelling question: could the very nature of galaxies themselves hold the key to why intelligent life remains unseen?

Watch my exclusive video The Fermi Paradox: Air https://nebula.tv/videos/isaacarthur–… Nebula using my link for 40% off an annual subscription: https://go.nebula.tv/isaacarthur Get a Lifetime Membership to Nebula for only $300: https://go.nebula.tv/lifetime?ref=isa… Use the link gift.nebula.tv/isaacarthur to give a year of Nebula to a friend for just $30. Visit our Website: http://www.isaacarthur.net Join Nebula: https://go.nebula.tv/isaacarthur Support us on Patreon: / isaacarthur Support us on Subscribestar: https://www.subscribestar.com/isaac-a… Facebook Group: / 1,583,992,725,237,264 Reddit: / isaacarthur Twitter: / isaac_a_arthur on Twitter and RT our future content. SFIA Discord Server: / discord Credits: The Fermi Paradox: Galactic Great Filters Episode 484; January 30, 2025 Written, Produced & Narrated by: Isaac Arthur Select imagery/video supplied by Getty Images Music Courtesy of Epidemic Sound http://epidemicsound.com/creator Phase Shift, “Forest Night” Chris Zabriskie, “Unfoldment, Revealment” Stellardrone, “Billions and Billions“
Get Nebula using my link for 40% off an annual subscription: https://go.nebula.tv/isaacarthur.
Get a Lifetime Membership to Nebula for only $300: https://go.nebula.tv/lifetime?ref=isa…
Use the link gift.nebula.tv/isaacarthur to give a year of Nebula to a friend for just $30.

Visit our Website: http://www.isaacarthur.net.
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Continue reading “The Fermi Paradox: Galactic Great Filters” | >

Scientists have studied the moon’s surface for decades to help piece together its complex geological and evolutionary history. Evidence from the lunar maria (dark, flat areas on the moon filled with solidified lava) suggested that the moon experienced significant compression in its distant past. Researchers suspected that large, arching ridges on the moon’s near side were formed by contractions that occurred billions of years ago—concluding that the moon’s maria has remained dormant ever since.

However, a new study reveals that what lies beneath the lunar surface may be more dynamic than previously believed. Two Smithsonian Institution scientists and a University of Maryland geologist discovered that small located on the moon’s far side were notably younger than previously studied ridges on the near side. Their findings were published in The Planetary Science Journal on January 21, 2025.

“Many scientists believe that most of the moon’s geological movements happened two and a half, maybe three billion years ago,” said Jaclyn Clark, an assistant research scientist in UMD’s Department of Geology. “But we’re seeing that these tectonic landforms have been recently active in the last billion years and may still be active today. These small mare ridges seem to have formed within the last 200 million years or so, which is relatively recent considering the moon’s timescale.”

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ANEMEL researchers have created a catalyst for water splitting that’s efficient and stable, without relying on scarce platinum group metals (PGMs). The study, recently published in Energy & Environmental Science, reports a high-performance PGM-free catalyst for the cathode in water electrolysis, responsible for the reaction that creates green hydrogen.

Current anion exchange membrane (AEM) water electrolyzers rely on PGMs, which are scarce and expensive. Specifically, these metals are used as catalysts at the cathode, where hydrogen is generated. However, ANEMEL AEM electrolyzers avoid PGMs, opting instead for more abundant metals such as nickel. This is essential to enable the wide adoption of electrolyzers: it helps to decrease the cost of electrolyzer components and improve their recyclability, reducing waste and providing a competitive advantage.

This requires investigating innovative ways to ensure electrolyzers perform at least as well, if not better than, those made with PGMs. After all, platinum and other metals in this group offer excellent activity and stability, especially at high current densities in electrolyzer environments, something PGM-free catalysts still don’t.

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RNA sequencing has emerged as a powerful tool for detecting various types of cancers and gaining a deeper understanding of tumor biology.

However, many samples used in these analyses are derived from tumor tissues preserved as formalin-fixed paraffin-embedded (FFPE) blocks. While FFPE blocks are excellent for histological examination, they pose significant challenges for molecular analysis due to the potential degradation or crosslinking of genetic material.

This application note describes the use of targeted custom RNA panels to overcome these challenges by enabling the robust and sensitive detection of gene expression profiles from FFPE non-small cell lung cancer samples.

Continue reading “Future-Proof Your RNA-Seq Workflow” | >

Very interesting paper by Lindley et al. showing that two mRNAs can be spliced together with extremely high efficiency using an optimized ribozyme system, allowing expression of large genes after dual-AAV delivery for treatment of muscular dystrophies. #genetherapy #biotech #synbio

Ribozymes are small catalytic RNA sequences capable of nucleotide-specific self-cleavage found widespread in nature. Ribozyme cleavage generates distinct 2′, 3′-phosphate and 5′-hydroxyl termini that resemble substrates for recently characterized RNA repair pathways in cells. We report that ribozyme cleavage of two separate mRNAs activated their scarless trans-ligation and translation into full-length protein in eukaryotic cells, a process that we named StitchR (for Stitch RNA). Optimization of StitchR activity in mammalian cells resulted in a ~900-fold increase in protein expression that approached levels observed for genes expressed from single vectors. We demonstrate that StitchR can be harnessed for effective dual adeno-associated virus gene therapies to correct muscular dystrophies by restoring large functional muscle proteins to endogenous levels in vivo.

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Simultaneous measurements of the optical force and power exerted by a collimated laser beam on a 50-nm-thick silicon nitride lightsail membrane suspended by compliant micromechanical springs quantify the radiation pressure, enabling further multiphysics studies of radiation pressure forces on macroscopic objects.

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