Lifeboat Foundation: Safeguarding Humanity
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Abstract

As the number of reverse shoulder arthroplasty (RSA) procedures increases, so does the incidence of revision surgery. Baseplate-related complications account for the highest proportion of these revisions, and it has been reported that improving baseplate fixation reduces the likelihood of failure. The present study aims to evaluate the initial stability of the baseplate to the glenoid after RSA. A finite element analysis (FEA) was performed using LS-DYNA models of the scapula and the SMR shoulder system, with a load of 30 N applied in both abduction and flexion, using the baseplate implantation surface as the reference. Micromotion was defined as the difference in displacement between the baseplate and the scapular fossa. The results demonstrated that micromotion between the glenoid and the baseplate diminished with increasing elevation in both abduction and flexion. It is hypothesised that in the SMR shoulder system, the screws are pressed into the glenoid during abduction, thereby contributing to enhanced initial stability.

RSA, rTSA, Baseplate, Finite Element Methods, Micromotion.

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Perhaps the most profound insight to emerge from this uncanny mirror is that understanding itself may be less mysterious and more mechanical than we have traditionally believed. The capabilities we associate with mind — pattern recognition, contextual awareness, reasoning, metacognition — appear increasingly replicable through purely algorithmic means. This suggests that consciousness, rather than being a prerequisite for understanding, may be a distinct phenomenon that typically accompanies understanding in biological systems but is not necessary for it.

At the same time, the possibility of quantum effects in neural processing reminds us that the mechanistic view of mind may be incomplete. If quantum retrocausality plays a role in consciousness, then our subjective experience may be neither a simple product of neural processing nor an epiphenomenal observer, but an integral part of a temporally complex causal system that escapes simple deterministic description.

What emerges from this consideration is not a definitive conclusion about the nature of mind but a productive uncertainty — an invitation to reconsider our assumptions about what constitutes understanding, agency, and selfhood. AI systems function as conceptual tools that allow us to explore these questions in new ways, challenging us to develop more sophisticated frameworks for understanding both artificial and human cognition.

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The return of the Dire wolves?

Colossal Biosciences’ project to revive the once-extinct dire wolf could also prevent existing but endangered animals from slipping into extinction themselves.

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The world is littered with trillions of micro- and nanoscopic pieces of plastic. These can be smaller than a virus—just the right size to disrupt cells and even alter DNA. Researchers find them almost everywhere they’ve looked, from Antarctic snow to human blood.

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A week before Tropical Cyclone Alfred was nearing the east coast of Australia, most forecasts were favouring a path either well offshore or near the central Queensland coast.

There was a curious anomaly though: an AI prediction from Google’s DeepMind, called Graphcast, was predicting the centre of Alfred would be just 200 kilometres off the coast of Brisbane.

That forecast, made 12 days before ex-Tropical Cyclone Alfred crossed the south-east Queensland coast, was far more accurate than leading weather models used by meteorological organisations around the world, including our own Bureau of Meteorology (BOM).

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Northwestern Medicine investigators have discovered previously unknown metabolic changes that may contribute to the development of estrogen receptor–negative (ERneg) breast cancer, according to recent findings published in Science Advances.

The study, led by Susan Clare, ‘90 MD, ‘88 Ph.D., research associate professor of Surgery, and Seema Khan, MD, the Bluhm Family Professor of Cancer, has the potential to inform new targeted preventives and therapeutics for patients who currently have limited treatment options.

Mariana Bustamante Eduardo, Ph.D., a postdoctoral fellow in the Khan/Clare laboratory, was lead author of the study.

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