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New method detects lung antibodies through non-invasive exhaled breath

For the first time, researchers have succesfully measured antibodies against specific respiratory viruses in exhaled air. This is shown in a new study involving, amongst others, the Karolinska Institutet, published in eBioMedicine. The method may make it easier to study the immune system in the small airways of the lungs.

Antibodies in the mucosal lining of the respiratory tract play an important role in protecting against respiratory viruses such as influenza virus, SARS-CoV-2 and respiratory syncytial virus (RSV). While antibodies in the upper airways are relatively easy to measure, sampling from the lower airways has previously required invasive procedures such as bronchoscopy.

In the new study, researchers used a non-invasive method called PExA (Particles in Exhaled Air). By breathing into a specially designed instrument, participants generated tiny exhaled particles originating from the respiratory tract lining fluid of the small airways. These particles were collected and analysed for virus-specific antibodies.

Cytokine Signaling in Tumor Progression

Cytokines are molecules that play critical roles in the regulation of a wide range of normal functions leading to cellular proliferation, differentiation and survival, as well as in specialized cellular functions enabling host resistance to pathogens. Cytokines released in response to infection, inflammation or immunity can also inhibit cancer development and progression. The predominant intracellular signaling pathway triggered by cytokines is the JAK-signal transducer and activator of transcription (STAT) pathway. Knockout mice and clinical human studies have provided evidence that JAK-STAT proteins regulate the immune system, and maintain immune tolerance and tumor surveillance. Moreover, aberrant activation of the JAK-STAT pathways plays an undeniable pathogenic role in several types of human cancers.

Cancer-linked gene uses ‘shortcut’ to trigger cell division

Living cells are one of the few materials that can replicate themselves, and this is crucial for tissue development and recovery from injury or illness. But making sure cell division only happens at the right time is essential; otherwise, unregulated replication can lead to problems like cancer.

Researchers at the University of California, Santa Cruz, are studying how cells know when and how to divide, and how genes known to be important in cancer influence these processes.

A new study published in The EMBO Journal finds that a gene affected in many cancers, known as E2F1, can cause cells to divide without having to abide by the normal rules of cell division. Instead of having to unpack the genetic material inside the cell, E2F1 takes a shortcut by binding directly to a small area of the DNA that remains tightly packaged inside the cell.

How Neuroscience Can Give Paralyzed People The Chance to Speak Again

A young adult man with closely cropped dark brown hair sits in a wheelchair in a dimly lit room, facing a computer screen on which a simple phrase is typed out: “How are you today?” Underneath the question on the screen, three dots appear—similar to the ones messaging apps use to signal that your conversation partner is composing a response—and flash with anticipation. One by one, new words materialize: “I am very good.”

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At first glance, this brief conversation doesn’t seem particularly special, but the man’s situation is anything but ordinary. On top of his head is a small box, about one inch square in size, connected to a circular portal in his skull about the size of a nickel. Protruding from the box is a thin black cable. The man, who goes by the nickname Pancho, is paralyzed and unable to speak, but a BCI records brain waves from the part of his cortex that is responsible for generating speech, the vocal motor cortex, and translates them into words on the computer screen.