Lifeboat Foundation

Scientists at Boston Children’s Hospital identified a defect that causes a genetic disorder in 50% of autism sufferers — and two existing classes of drugs that counter the defect.

Studies of different animal species suggest a link between eating less and living longer, but the molecular mechanisms by which caloric restriction affords protection against disease and extends longevity are not well understood.

New clues to help solve the mystery are presented in an article published in the September issue of Aging Cell by scientists at the Center for Research on Redox Processes in Biomedicine (Redoxoma), one of the Research, Innovation and Dissemination Centers (RIDCs) funded by FAPESP.

The results of in vitro and in vivo experiments performed by the Redoxoma team included the finding that a 40% reduction in dietary caloric intake increases mitochondrial calcium retention in situations where intracellular calcium levels are pathologically high. In the brain, this can help avoid the death of neurons that is associated with Alzheimer’s disease, Parkinson’s disease, epilepsy and stroke, among other neurodegenerative conditions.

PCG-1α therapy shows promise in treating age-related decline.

It is always a good idea to look closely at the biochemistry involved in any potential Alzheimer’s disease therapy that shows promise in mouse models. There is perhaps more uncertainty for Alzheimer’s than most other age-related conditions when it comes to the degree to which the models are a useful representation of the disease state in humans — which might go some way towards explaining the promising failures that litter the field. In the research here, the authors are aiming to suppress a step in the generation of amyloid-β, one of the proteins that aggregates in growing amounts and is associated with brain cell death in Alzheimer’s disease. They achieve this goal using gene therapy to increase the level of PGC-1α, which in turn reduces the level of an enzyme involved in the production of amyloid-β. Interestingly, increased levels of PGC-1α have in the past been shown to produce modest life extension in mice, along with some of the beneficial effects to health associated with calorie restriction.

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Continue reading “PGC-1α Gene Therapy Slows Alzheimer’s Progression in Mouse Model” »

Athletes with disabilities have been competing in a range of challenges that use assistive technology to overcome day-to-day practical challenges.

Bionic arms, powered exoskeletons, brain-controlled computer interfaces and supercharged wheelchairs all featured at the world’s first Cybathlon, near Zurich, Switzerland.

One of the races saw functional electrical stimulation (FES) used to activate the leg muscles of paralysed competitors to ride bikes.

It’s impressive enough that our human brains are made up of the same ‘star stuff’ that forms the Universe, but new research suggests that this might not be the only thing the two have in common.

Just like the Universe, our brains might be programmed to maximise disorder — similar to the principle of entropy — and our consciousness could simply be a side effect.

The quest to understand human consciousness — our ability to be aware of ourselves and our surroundings — has been going on for centuries. Although consciousness is a crucial part of being human, researchers still don’t truly understand where it comes from, and why we have it.

Continue reading “Consciousness could be a side effect of ‘entropy’, say researchers” »

A recent newspaper article under the headline “High street eye test can provide early indication of dementia” highlighted yet another complex connection between the eye and the brain.

This important eye-brain interface is still being researched and many disciplines are now working together to make fresh findings. But while most of us know that regular physical activity and eating healthily can help maintain or improve our well-being, few are aware of the importance of feeding our eyes with the right kind of light. Indeed, not experiencing the right quality and quantity of light could have adverse effects on hormonal changes, sleep patterns and may even be linked to obesity.

Novel treatments for neurological diseases might be possible with a flexible mesh that can prod individual brain cells.

Now, from the wild side.

Quantum Theory Proves Consciousness Moves To Another Universe After Death. There is an interesting new theory emerging from a scientist long familiar with physics, quantum mechanics and astrophysics. Biocentrism teaches that life and consciousness are fundamental to the universe. It is consciousness that creates the material universe, not the other way around. At least, the new thinking that has given birth to the new theory of biocentrism, which the professor, Dr. Robert Lanza, freely espouses. Lana has been voted the 3rd most important scientist alive by the NY Times. Lanza is an expert in regenerative medicine and scientific director of Advanced Cell Technology Company. Before he has been known for his extensive research which dealt with stem cells, he was also famous for several successful experiments on cloning endangered animal species. Biocentrism—is a concept proposed in 2007 by American doctor of medicine Robert Lanza, a scientist in the fields of regenerative medicine and biology, which sees biology as the central driving science in the universe, and an understanding of the other sciences as reliant on a deeper understanding of biology. Biocentrism states that life and biology are central to being, reality, and the cosmos—consciousness creates the universe rather than the other way around. It asserts that current theories of the physical world do not work, and can never be made to work, until they fully account for life and consciousness. While physics is considered fundamental to the study of the universe, and chemistry fundamental to the study of life, biocentrism claims that scientists will need to place biology before the other sciences to produce a theory of everything.

Continue reading “Biocentrism: Where The SOUL Goes After Death [VIDEO]” »

In Brief:

• Scientists have found a way of reactivating genes in mice to continue neuron growth.
• The development could be key to helping patients with paralysis and neurodegenerative diseases.