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Category: neuroscience – Page 876

Vascular risk and accumulation of beta-amyloids seem to accelerate the rate of cognitive decline in elderly adults.

Vascular risk appears to be a strong predictor of dementia, especially in older individuals with high levels of brain beta-amyloids, and the interaction between these two risk factors might lead to a higher rate of cognitive decline, according to a recent study at the Massachusetts General Hospital.

Alzheimer’s disease (AD) is an age-related neurological disorder whose most feared outcome is dementia, along with other symptoms, such as behavioral issues, loss of motivation, and even the inability to take care of oneself. Patients suffering from AD exhibit an accumulation of plaques in their brains; these plaques, resulting from the build-up of amyloid-beta protein, have long been thought to be the cause of the disease, though other hypotheses have been put forward as well.

However, the presence of excess beta amyloids is a constant in all AD patients, and a recent study by researchers at the Massachusetts General Hospital has discovered that increased cardiovascular risk, combined with higher brain amyloid levels, is a predictor of faster cognitive decline in clinically normal elderly. [1].

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Physical exercise is a key piece of the brain health puzzle, but certainly not a magic pill.

___ Exercise ‘doesn’t slow’ progression of dementia (NHS Choices): A trial in which people with dementia took part in a moderately intense exercise programme for 4 months found their mental decline did not slow and may even have worsened faster than in people who did not take part in the programme…While the exercise.

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Efforts to connect human brains to computers have taken big leaps forward in recent years. Melding our minds with machines could provide the biggest single upgrade to human intelligence since our species evolved. But are we ready?

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Found in turmeric, curcumin has previously been shown to have anti-inflammatory and antioxidant properties in lab studies. It also has been suggested as a possible reason that senior citizens in India, where curcumin is a dietary staple, have a lower prevalence of Alzheimer’s disease and better cognitive performance.

“Exactly how curcumin exerts its effects is not certain, but it may be due to its ability to reduce brain inflammation, which has been linked to both Alzheimer’s disease and major depression,” said Dr. Gary Small, director of geriatric psychiatry at UCLA’s Longevity Center and of the geriatric psychiatry division at the Semel Institute for Neuroscience and Human Behavior at UCLA, and the study’s first author.

The double-blind, placebo-controlled study involved 40 adults between the ages of 50 and 90 years who had mild memory complaints. Participants were randomly assigned to receive either a placebo or 90 milligrams of curcumin twice daily for 18 months.

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Stem cells in the brain can divide and mature into neurons participating in various brain functions, including memory. In a paper scientists have discovered that the flow of cerebrospinal fluid is a key signal for neural stem cell renewal.

The ancient Greek aphorism panta rhei means “everything flows”, a phrase used by philosophers to describe the constant flux and interplay between the past and renewal. A recent paper lends this relationship a whole new meaning: a team of researchers headed by Professor Magdalena Götz and their collaborators from the LMU (Professor Benedikt Grothe, Chair of Neurobiology) and the Henrich-Heine University Düsseldorf have discovered that the flow of is a key signal for neural stem cell renewal.

“Neural in the brain can divide and mature into neurons and this process plays important roles in various regions of the brain – including olfactory sense and memory,” explains Magdalena Götz, Head of LMU Department of Physiological Genomics and Director of the Institute for Stem Cell Research at Helmholtz Zentrum München. “These are located in what is known as the neurogenic stem cell niche one of which is located at the walls of the lateral ventricles, where they are in contact with circulating cerebrospinal fluid.”

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Important new study to track — “The team will start recruiting the first of 1,000 low-income mothers next week…Of that 1,000, roughly half will be randomly selected to receive an unconditional $333 a month, while the others will form a control group that will receive $20. The money, which is completely unconditional, will be loaded onto a pre-paid debit card every month for 40 months, on the date of the child’s birthday. The hypothesis is that this steady stream of payments will make a positive difference in the cognitive and emotional development of the children whose mothers receive it”

___ Does growing up poor harm brain development? (The Economist): “Plenty of evidence suggests that growing up poor, living through these kinds of scrapes, has a detrimental impact on child development. Children from rich families tend to have better language and memory skills than those from poor families. More.

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