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Category: neuroscience – Page 677

What Is It About the Human Brain That Makes Us Smarter Than Other Animals? New Research

Humans are unrivaled in the area of cognition. After all, no other species has sent probes to other planets, produced lifesaving vaccines, or created poetry. How information is processed in the human brain to make this possible is a question that has drawn endless fascination, yet no definitive answers.

Our understanding of brain function has changed over the years. But current theoretical models describe the brain as a “distributed information-processing system.” This means it has distinct components that are tightly networked through the brain’s wiring. To interact with each other, regions exchange information though a system of input and output signals.

However, this is only a small part of a more complex picture. In a study published last week in Nature Neuroscience, using evidence from different species and multiple neuroscientific disciplines, we show that there isn’t just one type of information processing in the brain. How information is processed also differs between humans and other primates, which may explain why our species’ cognitive abilities are so superior.

Light-activated “photoimmunotherapy” kills brain cancer, reduces relapse

Scientists at the Institute of Cancer Research in London have developed a new light-activated “photoimmunotherapy” that could help treat brain cancer. The key is a compound that glows under light to guide surgeons to the tumor, while near-infrared light activates a cancer-killing mechanism.

The new study builds on a common technique called Fluorescence Guided Surgery (FGS), which involves introducing a fluorescent agent to the body which glows under exposure to light. This is paired with a synthetic molecule that binds to a specific protein, such as those expressed by cancer cells. The end result is tumors that glow under certain lighting conditions or imaging, guiding surgeons to remove the affected cells more precisely.

For the new study, the researchers gave the technique an extra ability – killing the cancer as well. They added a new molecule that binds to a protein called EGFR, which is often mutated in cases of the brain cancer glioblastoma. After the fluorescence has helped surgeons remove the bulk of the tumor, they can shine near-infrared light on the site, which switches the compound into a tumor-killing mode by releasing reactive oxygen species. The idea is to kill off any remaining cells that could – and often do – stage an aggressive comeback after surgery.

At the crossroad of the search for spontaneous radiation and the Orch OR consciousness theory

Based on a novel intertwined theoretical and experimental approach, we examined one of the pillars of the Orch OR model, namely the gravity-related collapse model. In this context, we examined the Orch OR calculations using the gravity-related (called Diosi-Penrose, DP, for reasons we explain in the article) theory along with recent experimental constraints on the DP cutoff parameter (R0). We showed that, in this context, the Orch OR based on the DP theory is definitively ruled out for the case of atomic nuclei level of separation, without needing to consider the impact of environmental decoherence; we also showed that the case of partial separation requires the brain to maintain coherent superpositions of tubulin of such mass, duration, and size that vastly exceed any of the coherent superposition states that have been achieved with state-of-the-art optomechanics and macromolecular interference experiments. We conclude that none of the scenarios we discuss (with possible exception to the case of partial separation of tubulins) are plausible.

The Brain Has a ‘Low-Power Mode’ That Blunts Our Senses

When our phones and computers run out of power, their glowing screens go dark and they die a sort of digital death. But switch them to low-power mode to conserve energy, and they cut expendable operations to keep basic processes humming along until their batteries can be recharged.

Our energy-intensive brain needs to keep its lights on too. Brain cells depend primarily on steady deliveries of the sugar glucose, which they convert to adenosine triphosphate (ATP) to fuel their information processing. When we’re a little hungry, our brain usually doesn’t change its energy consumption much. But given that humans and other animals have historically faced the threat of long periods of starvation, sometimes seasonally, scientists have wondered whether brains might have their own kind of low-power mode for emergencies.

Now, in a paper published in Neuron in January, neuroscientists in Nathalie Rochefort’s lab at the University of Edinburgh have revealed an energy-saving strategy in the visual systems of mice. They found that when mice were deprived of sufficient food for weeks at a time — long enough for them to lose 15%-20% of their typical healthy weight — neurons in the visual cortex reduced the amount of ATP used at their synapses by a sizable 29%.

Digital Computers Will Remain Unconscious Until They Recruit Physical Fields for Holistic Computing Using Well-Defined Topological Boundaries

[Epistemic Status: written off the top of my head, thought about it for over a decade]

What do we desire for a theory of consciousness?

We want it to explain why and how the structure of our experience is computationally relevant. Why would nature bother to wire, not only information per se, but our experiences in richly structured ways that seem to track task-relevant computation (though at times in elusive ways)?

Gut microbiome acts on the brain to control appetite

The brain is the central information center and constantly monitors the state of every organ present in a body. Previous research has shown that the brain also receives signals from the gut microbiota.

In a new Immunity journal study, researchers discuss the work of Gabanyi et al. (2022), published in a recent issue of Science, which reveals that hypothalamic gamma-aminobutyric acid (GABAergic) neurons recognize microbial muropeptides through the cytosolic receptor NOD2, which regulates food intake and body temperature.

Connection Map Reveals Changes in the Injured Brain

Scientists from the University of California, Irvine have discovered that an injury to one part of the brain changes the connections between nerve cells across the entire brain. The new research was published this week in Nature Communications.

Every year in the United States, nearly two million Americans sustain a traumatic brain injury (TBI). Survivors can live with lifelong physical, cognitive and emotional disabilities. Currently, there are no treatments.

One of the biggest challenges for neuroscientists has been to fully understand how a TBI alters the cross-talk between different cells and brain regions.

Rune Labs secures FDA clearance to use Apple Watch to track Parkinson’s symptoms

Rune Labs, a precision neurology company, has announced its StrivePD software ecosystem for Parkinson’s disease has been granted 510(k) clearance by the US Food and Drug Administration (FDA) to collect patient symptom data through measurements made by Apple Watch.

By combining powerful wearable technology and self-reported symptom information with brain imaging, electrophysiology, genetic and other clinical data, StrivePD enables a data-driven approach to care management and clinical trial design for Parkinson’s.

Longevity. Technology: With this clearance, the Rune Labs’ StrivePD app enables precision clinical care and trial participation for tens of thousands of Parkinson’s patients who already use these devices in their daily lives.

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