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Learning and Protecting Itself: How the Brain Adapts

Blocking matrix metalloproteinases MMP2 and MMP9 can have the opposite effect on neuroplasticity depending on whether the brain is healthy or injured.


Summary: Blocking the matrix metalloproteinases MMP2 and MMP9 can have the opposite effect on neuroplasticity depending on whether the brain is healthy or injured.

Source: University of Gottingen

The brain is a remarkably complex and adaptable organ. However, adaptability decreases with age. As new connections between nerve cells in the brain form less easily, the brain’s plasticity decreases.

If there is an injury to the central nervous system, such as after a stroke, the brain needs to compensate by reorganizing itself. To do this, a dense network of molecules between the nerve cells—known as the extracellular matrix—must loosen.

The Nuts and Bolts of Better Brains: Harnessing the Power of Neuroplasticity

What if your brain at 77 were as plastic as it was at 7? What if you could learn Mandarin with the ease of a toddler or play Rachmaninoff without breaking a sweat? A growing understanding of neuroplasticity suggests these fantasies could one day become reality. Neuroplasticity may also be the key to solving diseases like Alzheimer’s, depression, and autism. In this program, leading neuroscientists discuss their most recent findings and both the tantalizing possibilities and pitfalls for our future cognitive selves.

PARTICIPANTS: alvaro pascual-leone, nim tottenham, carla shatz.

MODERATOR: Guy McKhann.

MORE INFO ABOUT THE PROGRAM AND PARTICIPANTS: https://www.worldsciencefestival.com/programs/nuts-bolts-bet…lasticity/

This program is part of the BIG IDEAS SERIES, made possible with support from the JOHN TEMPLETON FOUNDATION.

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Temporal self-compression: Behavioral and neural evidence that past and future selves are compressed as they move away from the present

For centuries, great thinkers have struggled to understand how people represent a personal identity that changes over time. Insight may come from a basic principle of perception: as objects become distant, they also become less discriminable or “compressed.” In Studies 1–3, we demonstrate that people’s ratings of their own personality become increasingly less differentiated as they consider more distant past and future selves. In Study 4, we found neural evidence that the brain compresses self-representations with time as well. When we peer out a window, objects close to us are in clear view, whereas distant objects are hard to tell apart. We provide evidence that self-perception may operate similarly, with the nuance of distant selves increasingly harder to perceive.

A basic principle of perception is that as objects increase in distance from an observer, they also become logarithmically compressed in perception (i.e., not differentiated from one another), making them hard to distinguish. Could this basic principle apply to perhaps our most meaningful mental representation: our own sense of self? Here, we report four studies that suggest selves are increasingly non-discriminable with temporal distance from the present as well. In Studies 1 through 3, participants made trait ratings across various time points in the past and future. We found that participants compressed their past and future selves, relative to their present self. This effect was preferential to the self and could not be explained by the alternative possibility that individuals simply perceive arbitrary self-change with time irrespective of temporal distance.

New metacognition research provides insight into how the brain looks at itself

The Neuro-Network.

𝐍𝐞𝐰 𝐦𝐞𝐭𝐚𝐜𝐨𝐠𝐧𝐢𝐭𝐢𝐨𝐧 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐩𝐫𝐨𝐯𝐢𝐝𝐞𝐬 𝐢𝐧𝐬𝐢𝐠𝐡𝐭 𝐢𝐧𝐭𝐨 𝐡𝐨𝐰 𝐭𝐡𝐞 𝐛𝐫𝐚𝐢𝐧 𝐥𝐨𝐨𝐤𝐬 𝐚𝐭 𝐢𝐭𝐬𝐞𝐥𝐟

𝙄𝙣 1,884, 𝙬𝙝𝙞𝙡𝙚 𝙖𝙩𝙩𝙚𝙢𝙥𝙩𝙞𝙣𝙜 𝙩𝙤 𝙙𝙚𝙛𝙞𝙣𝙚 𝙩𝙝𝙚 𝙡𝙞𝙢𝙞𝙩𝙨 𝙤𝙛 𝙝𝙪𝙢𝙖𝙣 𝙥𝙚𝙧𝙘𝙚𝙥𝙩𝙞𝙤𝙣, 𝘾𝙝𝙖𝙧𝙡𝙚𝙨 𝙋𝙞𝙚𝙧𝙘… See more.


In 1,884, while attempting to define the limits of human perception, Charles Pierce and Joseph Jastrow discovered something else: the limits of our insight into ourselves.

Participants in their experiments systematically under-rated their ability to correctly judge their own sensations, which Pierce and Jastrow offered as an explanation of “the insight of females as well as certain ‘telepathic’ phenomena”. These particular implications have thankfully been left behind (along with the conceptual relationship between telepathy and female insight). But by the late 1970s this approach of asking participants to rate their own performance had emerged as its own field of research: the study of “metacognition”.

Broadly, this ability to self-reflect and think about our own thoughts allows us to feel more or less confident in our decisions: we can act decisively when we’re confident we are correct, or be more cautious after we feel we’ve made an error.

Dr. David Berson: Your Brain’s Logic & Function

Listen: YouTube | Apple Podcasts | Spotify

In this episode, Dr. Huberman is joined by Dr. David Berson, Professor and Chairman of Neuroscience at Brown University. Dr. Berson discovered the neurons in your eye that set your biological rhythms for sleep, wakefulness, mood and appetite. He is also a world-renowned teacher of basic and advanced neuroscience, having taught thousands of university lectures on this topic. Many of his students have become world-leading neuroscientists and teachers themselves.

Here Dr. Berson takes us on a structured journey into and around the nervous system, explaining: how we perceive the world and our internal landscape, how we balance, see, and remember. Also, how we learn and perform reflexive and deliberate actions, how we visualize and imagine in our mind, and how the various circuits of the brain coordinate all these incredible feats.

New Research Finds Potential Mechanism Linking Autism and Intestinal Inflammation

Infection during pregnancy with elevated levels of the cytokine IL-17a may yield microbiome alterations that prime offspring for aberrant immune responses, mouse study suggests.

Though many people with autism spectrum disorders also experience unusual gastrointestinal inflammation, scientists have not established how those conditions might be linked. Now MIT

MIT is an acronym for the Massachusetts Institute of Technology. It is a prestigious private research university in Cambridge, Massachusetts that was founded in 1861. It is organized into five Schools: architecture and planning; engineering; humanities, arts, and social sciences; management; and science. MIT’s impact includes many scientific breakthroughs and technological advances.