Summary: Researchers leveraged a tracking algorithm from video games to study molecules’ behavior within live brain cells.
They adapted the fast and accurate algorithm used to track bullets in combat games for use in super-resolution microscopy. The innovative approach enables scientists to observe how molecules cluster together to perform specific functions in space and time within the brain cells.
The data obtained could shed light on molecular functions’ disruption during aging and disease.
Researchers at Scripps Research have discovered that chronic alcohol consumption can increase sensitivity to pain through two distinct molecular mechanisms: one related to alcohol intake and the other to alcohol withdrawal. This finding, published in the British Journal of Pharmacology, sheds light on the intricate relationship between alcohol and pain.
The researchers sought to better understand the relationship between chronic pain and alcohol use disorder. They wanted to investigate the underlying causes of different types of alcohol-related pain, such as alcoholic neuropathy and allodynia, and how they develop at the spinal cord level. The researchers aimed to examine the role of microglia, immune cells in the central nervous system, in the development of chronic alcohol-induced allodynia and neuropathy.
Alcoholic neuropathy refers to nerve damage caused by long-term excessive alcohol consumption. It is a type of peripheral neuropathy that affects the peripheral nerves, which are responsible for transmitting signals between the brain, spinal cord, and the rest of the body.
Sam Harris is an American author, philosopher, neuroscientist, and podcast host.
His work touches on a wide range of topics, including rationality, religion, ethics, free will, neuroscience, meditation, philosophy of mind, politics, terrorism, and artificial intelligence.
His academic background is in philosophy and cognitive neuroscience.
A new research at the intersection of cosmology and neurobiology implies that diverse physical processes lead to similar levels of complexity and self-organization present in structures of scales.
An astrophysicist at the University of Bologna and a neurosurgeon at the University of Verona compared the network of neuronal cells in the human brain with the cosmic network of galaxies and found astounding similarities.
In their paper ‘The quantitative comparison between the neuronal network and the cosmic web’ published in Frontiers in Physics, Franco Vazza, astrophysicist at the University of Bologna, and Alberto Feletti, neurosurgeon at the University of Verona, investigated the similarities between two of the most complex systems in existence: the cosmic web of galactic superclusters and the network of neuronal cells in the human brain.
Cancer remains one of the leading causes of death in the US at over 600,000 deaths per year. Cancers that form solid tumors such as in the breast, brain, or skin are particularly hard to treat. Surgery is typically the first line of defense for patients fighting solid tumors. But surgery may not remove all cancerous cells, and leftover cells can mutate and spread throughout the body. A more targeted and wholistic treatment could replace the blunt approach of surgery with one that eliminates cancer from the inside using our own cells.
Dennis Discher, Robert D. Bent Professor of Chemical and Biomolecular Engineering, and postdoctoral fellow Larry Dooling provide a new approach in targeted therapies for solid tumor cancers in their study, published in Nature Biomedical Engineering. Their therapy not only eliminates cancerous cells, but teaches the immune system to recognize and kill them in the future.
Scientists recently used electrical stimulation in the brains of epilepsy patients to investigate the relationship between brain activity and memory consolidation during sleep. They found that synchronizing the firing of neurons in the medial temporal lobe and neocortex through this stimulation improved memory consolidation, particularly for recognition memory tasks.
The findings, which have been published in Nature Neuroscience, contribute to our understanding of memory processes and may have important implications for the development of interventions for memory disorders and dementia.
The motivation behind this study was to investigate how the brain consolidates memories during sleep. While it is known that sleep plays a vital role in memory strengthening, the specific processes that occur in the brain during sleep are still not well understood.
Review discusses the increasing importance of two-dimensional nanomaterials like graphene in neuroscience, highlighting their potential in nerve repair, creating brain-mimicking synaptic devices, and treating neurological disorders. It also considers the challenges and future prospects of these materials in this complex field.
We know this, Kushner says, because issues with alcohol can start before people develop anxiety or depression. His research also suggests that having either a dependence on alcohol or an anxiety condition substantially increases the probability of developing the other condition within several years.
For Kushner, this two-way relationship suggests alcohol use disorder and anxiety and depression might share a root cause.
Kushner’s team’s latest research brings us one step closer to figuring out why these conditions are so closely linked: Their study suggests people with a diagnosis of anxiety or depression are more likely to experience alcohol use disorder symptoms than people without these conditions, even when they drink the same amount of alcohol. The results are published in the journal Alcohol: Clinical & Experimental Research.