Lifeboat Foundation

In a surprising study, Oregon State University researchers found that no matter how much stress they placed on mice from either a high-fat diet or strenuous exercise, the animals’ mitochondria were able to adapt and continue their normal processes.

The findings could have major implications for the study of diseases like diabetes, Parkinson’s and Alzheimer’s, all of which are associated with an impairment in the breaking-down and clearance of damaged mitochondria.

Mitochondria are the structures that house cellular respiration, the process used to turn nutrients into energy. Dysfunction in mitochondria may lead to lower energy production, greater inflammation and tissue damage. Yet as central as mitochondria are to living organisms, scientists still don’t know exactly what keeps them healthy—or makes them unhealthy.

The interactive art pop-up The End of You tackles the environmental crisis through a transhumanistic lens. It’ll even let you morph into a tree. Well, sorta.

A scrupulous gatekeeper stands between the brain and its circulatory system to let in the good and keep out the bad, but this porter, called the blood-brain barrier, also blocks trial drugs to treat diseases like Alzheimer’s or cancer from getting into the brain.

Now a team led by researchers at the Georgia Institute of Technology has engineered a way of studying the barrier more closely with the intent of helping drug developers do the same. In a new study, the researchers cultured the human blood-brain barrier on a chip, recreating its physiology more realistically than predecessor chips.

The new chip devised a healthy environment for the barrier’s central component, a brain cell called the astrocyte, which is not a neuron, but which acts as neurons’ intercessors with the circulatory system. Astrocytes interface in human brains with cells in the vasculature called endothelial cells to collaborate with them as the blood-brain barrier.

Identifying biological correlates of late life cognitive function is important if we are to ascertain biomarkers for, and develop treatments to help reduce, age-related cognitive decline. Here, we investigated the associations between plasma levels of 90 neurology-related proteins (Olink® Proteomics) and general fluid cognitive ability in the Lothian Birth Cohort 1936 (LBC1936, N = 798), Lothian Birth Cohort 1921 (LBC1921, N = 165), and the INTERVAL BioResource (N = 4451). In the LBC1936, 22 of the proteins were significantly associated with general fluid cognitive ability (β between −0.11 and −0.17). MRI-assessed total brain volume partially mediated the association between 10 of these proteins and general fluid cognitive ability. In an age-matched subsample of INTERVAL, effect sizes for the 22 proteins, although smaller, were all in the same direction as in LBC1936. Plasma levels of a number of neurology-related proteins are associated with general fluid cognitive ability in later life, mediated by brain volume in some cases.

Important research happening. thank you SENS. if you don’t know what SENS is, take a moment to check them out.

Albert Einstein College of Medicine.

Neuroscientists-can-now-design-false-memories-and-plant-them-into-animal-brains.

Jake Anderson, The Mind Unleashed Waking Times

Continue reading “Neuroscientists Can Now Design False Memories and Plant Them Into Animal Brains” »

Thanks to an experimental new brain implant, a blind woman gets her first glimpse of lights, shapes, and people in 15 years.

A research team has shown that a key difference between neurogenic and non-neurogenic tissues is cross-linking proteins causing stiffness, a discovery that could be used to create new brain injury therapies.

Researchers compared the proteomes of regions in the brain that are neurogenic (neural stem cell niches) and those that are not (cerebral cortex). The scientists hope that by establishing how these tissues are different, future therapies for brain injury may be able to activate tissues to produce new neurons to repair the brain.

Antidepressant-soil.

Soil microbes have been found to have similar effects on the brain as prozac, without the negative side effects and potential for chemical dependency and withdrawal.

It turns out getting in the garden and getting dirty is a natural antidepressant due to unique microbes in healthy organic soil. Working and playing in soil can actually make you happier and healthier.

Continue reading “Antidepressant Microbes In Soil: How Soil Makes Your Brain Happy” »