Lifeboat Foundation

My guest tomorrow on Womens Radio Station at 1pm is Dr Ian Hale. Author of ‘Asperger’s Autism & You’

www.womensradiostation.com

Hale, Ian] on Amazon.com. *FREE* shipping on qualifying offers. Asperger’s, Autism & You.

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How does consciousness arise? What might its relationship to matter be? And why are some things conscious while others apparently aren’t? These sorts of questions, taken together, make up what’s called the “hard problem” of consciousness, coined some years ago by the philosopher David Chalmers. There is no widely accepted solution to this. But, fortunately, we can break the problem down: If we can tackle what you might call the easy part of the hard problem, then we might make some progress in solving the remaining hard part.

This is what I’ve been up to in recent years with my partner in crime, Jonathan Schooler, a psychologist at U.C. Santa Barbara. Since I came up in philosophy, rather than neuroscience or psychology, for me the easy part was deciding the philosophical orientation. Schooler and I duked it out over whether we should adopt a materialist, idealist, panpsychist, or some other position on our way to a complete answer. I am, as I’ve written in Nautilus before, a card-carrying panpsychist, inspired by Alfred North Whitehead, David Ray Griffin, David Skrbina, William Seager, and Chalmers. Panpsychism suggests that all matter has some associated mind/consciousness and vice versa. Where there is mind there is matter, where there is matter there is mind. They go together like inside and outside. But for Jonathan, this was far too glib. He felt strongly that this was actually the hard part of the problem. Since he’s the Distinguished Professor and I’m not, we decided to call this philosophical positioning the hard part of the hard problem.

Consciousness is a snapshot of time.

Also, consider that some people with medical conditions may not be comfortable making eye contact.

“In the past, it has been assumed that eye contact creates synchrony, but our findings suggest that it’s not that simple,” says senior author Thalia Wheatley, a professor of psychological and brain sciences at Dartmouth, and principal investigator of the Dartmouth Social Systems Laboratory.

Summary: Study reveals a correlation between instances of eye contact and higher levels of engagement during conversations.

Continue reading “Making And Breaking Eye Contact Makes Conversation More Engaging” »

A bitter divorce battle in Russia has led to cryogenically frozen bodies being seized in an extraordinary day-time raid.

Staff of a company set up by Valeria Udalova, 59 grabbed the remains of people — including from Britain and the US — who paid thousands of pounds hoping to be brought back to life when science advances to allow this.

She and her team raided the company run by her ex-husband Danila Medvedev, 41 near Moscow, which is home to Russia’s leading cryo-storage facility, say reports.

Hyperbaric oxygen therapy improved cerebral blood flow by up to 23%, alleviating vascular dysfunction and amyloid burden in elderly patients. The treatment also improved memory by 16.5%.

“Identification of these compounds means that we are one step closer to being able to molecularly diagnose dementia,” said senior author of the study, Professor Mitsuhiro Yanagida, who leads the G0 Cell Unit at OIST.

Summary: Researchers identified 33 metabolic compounds in blood samples that differed between those with dementia and cognitively healthy older adults. 7 of the metabolites were elevated in dementia patients, while 26 were at lower levels compared to samples of those without dementia. Elevating levels of those metabolites could have a neuroprotective effect against dementia.

Source: OIST

Continue reading “Signs of Dementia Are Written in the Blood” »

Many human diseases can differ between males and females in their prevalence, manifestation, severity or age of onset. Examples include Lupus, where more than 80% of patients are females; Alzheimer’s disease, where females have higher incidence and tend to suffer quicker cognitive decline; and COVID-19 infections that are frequently more severe in males.

These sex differences may have a genetic basis that is attributable to the sex chromosomes. The X chromosome—one of the two sex chromosomes—is known to play an important role in human development and disease. New research led by Penn State College of Medicine reveals for the first time that sex-biased diseases can be attributable to genes that escape X chromosome inactivation (XCI), a process that ensures that females do not overexpress genes on their X-chromosomes.

The team developed a genetic tool that can identify these XCI escape genes, and it may also help in determining whether a female will develop a sex-biased disease and if the disease will become progressively worse over time. The tool may even be useful in understanding the sex differences in immune responses to COVID-19, as the disease is thought to produce more severe symptoms and higher mortality in men than in women.

Summary: A new study on aging reveals a surprising discovery about the connection between protein shape and mitochondrial health.

Source: Buck Institute.

Every cell in the body goes through thousands of chemical reactions each day, and each reaction involves tiny protein molecules folded into precise shapes to perform their functions. Misfolded proteins underlie some of the most common and devastating diseases of aging, like Alzheimer’s and Parkinson’s. A major focus of aging research is discovering ways to maintain protein shape and prevent misfolded proteins from wreaking havoc on cellular function.

New photo-oxygenation catalyst targets amyloid structure, recruits brain immune system cells.

A small, light-activated molecule recently tested in mice represents a new approach to eliminating clumps of amyloid protein found in the brains of Alzheimer’s disease patients. If perfected in humans, the technique could be used as an alternative approach to immunotherapy and used to treat other diseases caused by similar amyloids.

Researchers injected the molecule directly into the brains of live mice with Alzheimer’s disease and then used a specialized probe to shine light into their brains for 30 minutes each day for one week. Chemical analysis of the mouse brain tissue showed that the treatment significantly reduced amyloid protein. Results from additional experiments using human brain samples donated by Alzheimer’s disease patients supported the possibility of future use in humans.