A device the size of a matchstick, implanted next to the brain’s motor cortex, could one day help paralysed people move their limbs.
Category: neuroscience – Page 1,313
We talked to futurists about what sleep will be like in 2030
Interesting.
Futurists are accustomed to launching headfirst into some very complex subjects, but even the most high-minded and enthusiastic of prognosticators may take a pass when it comes to dealing with the future of sleep.
That’s no cop out.
It’s just that we humans — those in the developed world at least — maintain such a complicated relationship with sleep.
More Efficient CRISPR Gene Editing May Potentially Help Cure Diseases
Awesome.
Researchers have developed a new gene editing tool that is more efficient and easier to use. CRISPR-EZ addresses the issue of target RNA accuracy and embryo viability in IVF transgenic mice.
( andrew modzelewski/lin he | university of california berkeley )
CRISPR gene editing has been the subject of many researchers around the world because of its great potential in the study human genetic disease. But more than that, scientists have high regard for this tool because it can help cure complex and debilitating diseases like dementia and cancer.
As more fine-tuning is done in the use of CRISPR gene editing, more diseases can be effectively cured. CRISPR-Cas9 has been used to accurately replace or change genes but it is mostly done in early embryos, and there is a need to increase its accuracy and ease of use. With this in mind, researchers from the University of California (UC) Berkeley have developed a new method called CRISPR-EZ (CRISPR ribonucleoprotein electroporation of zygotes) that would make gene editing easier.
New discovery from the molecular machinery for depression and addiction
When nerve cells have to communicate with each other in our brains, it involves release of neurotransmitters acting as messengers at neural synapses. Here the released neurotransmitter is bound and registered by receptors at the surface of the receiving nerve cell. This will, in turn, trigger a signal which is sent on to other nerve cells. The circuits in the brain using the neurotransmitters noradrenaline, dopamine, GABA and serotonin are known to play an important role in mood, reward and mental well-being, and they also have a key role to in mental disorders such as addiction and depression.
After release of neurotransmitters between nerve cells, they must, however, be removed again to end the signal. This is done by a family of transport proteins which function as molecular vacuum cleaners in the cell membrane of the nerve cell where they pump the neurotransmitter back into the nerve cell for later reuse. This transport is of great importance to the signaling between the nerve cells, but happens relatively slowly. A collaborative project between researchers from Aarhus University has made it possible to explain what happens in the crucial rate-limiting step in the transport process for neurotransmitters such as serotonin, noradrenaline, GABA and dopamine which are all transported by related proteins with the same mechanism.
Investigating how ‘chemo brain’ develops in cancer patients
Interesting read on Chemo’s impact on the brain and brain functioning known as Chemo Brain.
During and after chemotherapy, many cancer patients describe feeling a mental fog, a condition that has been dubbed “chemo brain.” Why this happens is unclear, but researchers have found a new clue to understanding this syndrome. A study in the journal ACS Chemical Neuroscience reports that chemotherapy in rats affects their chemical messengers dopamine and serotonin, which are associated with cognition.
Poverty marks a gene, predicting depression
Not surprised;
A long line of research links poverty and depression. Now, a study by Duke University scientists shows how biology might underlie the depression experienced by high-risk adolescents whose families are socio-economically disadvantaged.
The study, published May 24, 2016 in the journal Molecular Psychiatry, combined genetics, brain imaging and behavioral data gathered as adolescents were followed for more than three years as part of a larger study.
The results are part of a growing body of work that may lead to biological predictors that could guide individualized depression-prevention strategies.
Researchers identify genes linked to the effects of mood and stress on longevity
The visible impacts of depression and stress that can be seen in a person’s face—and contribute to shorter lives—can also be found in alterations in genetic activity, according to newly published research.
In a series of studies involving both C. elegans worms and human cohorts, researchers from the Indiana University School of Medicine and the Scripps Research Institute have identified a series of genes that may modulate the effects of good or bad mood and response to stress on lifespan. In particular, the research pointed to a gene known as ANK3 as playing a key role in affecting longevity. The research was published May 24, 2016 in the Nature Publishing Group journal Molecular Psychiatry, the top ranked journal in the field of psychiatry.
“We were looking for genes that might be at the interface between mood, stress and longevity”, said Alexander B. Niculescu III, M.D., Ph.D., professor of psychiatry and medical neuroscience at the IU School of Medicine. “We have found a series of genes involved in mood disorders and stress disorders which also seem to be involved in longevity.